Sentences with phrase «kinase complex»

Or, in other words, the cyclin - dependent kinase complex is the orchestra, while the metabolic oscillations beat the rhythm, like a conductor does.

All textbooks describe the cyclin - dependent kinase complex as the one and only / exclusive regulator of the eukaryotic cell cycle.

The overall picture Heinemann and his colleagues have sketched in the Molecular Cell article is a system, in which the metabolic oscillator pulls the cyclin - dependent kinase complex through its cycle and dynamically gate the occurrence of the different cell cycle events.

«We argue that metabolism and the cyclin - dependent kinase complex are coupled oscillators, which together orchestrate the growth and division of eukaryotic cells.»

Not exact matches

Our next steps will be to study the details of how R2TP and HSP90 are able to assemble the complexes made up of kinases of the mTOR family, in order to find ways of interfering with these processes,» concludes Llorca.

Óscar Llorca and his team have used this technique to learn about the structure and functioning of a complex system called R2TP, which is involved in various key processes for cell survival such as the activation of the kinases mTOR, ATR and ATM, proteins that are the target of various cancer drugs currently being developed.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

Unlike with protein kinases, the current knowledge of protein phosphatase functions and especially on their formed interactions and complexes remains fragmentary.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

The scientists have discovered that RingoA is a key activator of Cdk2, the protein kinase with which it forms a complex required for meiosis.

Upstream of the mTORC1 complex are several protein complexes and kinases, including two related protein complexes, GATOR1 and GATOR2, and the Rag GTPases.

In the cell, the protein kinase mTOR is found in two structurally and functionally distinct protein complexes termed mTORC1 and mTORC2 in mammals.

Proper transfer of V1 complexes or subunits from the membrane to the cytoplasm and back appears to require not only phosphorylation events, conformational changes in the V1VO holoenzyme, the V1 complex and the V1 subunit C, but also the temporary interaction with protein kinase A, cytoskeletal elements, the heterotrimeric protein complex RAVE and the glycolytic enzyme aldolase.

Monika Raab, Yuning Lu, Karsten Kohler, Xin Smith, Klaus Strebhardt & Christopher E. Rudd, «LFA - 1 activates focal adhesion kinases FAK1 / PYK2 to generate LAT - GRB2 - SKAP1 complexes that terminate T - cell conjugate formation», Nature Communications, 2017 July 12.

Disruption of Ca2 + - dependent cell - matrix adhesion enhances c - Src kinase activity, but causes dissociation of the c - Src / FAK complex and dephosphorylation of tyrosine - 577 of FAK in carcinoma cells.

Regulation of Postsynaptic Structure and Function by an A-Kinase Anchoring Protein — Membrane - Associated Guanylate Kinase Scaffolding Complex.

Protein kinase Cα and ζ differentially regulate death - inducing signaling complex formation in cigarette smoke extract - induced apoptosis.

She moved to Oxford in 2012 to work at the SGC, initially working in Alex Bullock's Growth Factor Signalling group to study E3 ubiquitin ligase complexes, and subsequently joining Stefan Knapp's kinase team to focus on kinase structural biology and inhibitor discovery.

Additionally, the drug was shown to inhibit the TRAF2 - and NCK - interacting kinase (TNIK), a regulatory component of the β - catenin and T - cell factor - 4 (TCF - 4) transcriptional complex downstream of the adenomatous polyposis coli (APC) gene product in colon cancer [30].

Distinct phosphodiesterase - 4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes.

Assembly of the PtdIns 4 - kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.

Protein kinase C$ ẹlta $ and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2 / 3 complex and cortactin.

Clathrin complexes with the inhibitor kappa B kinase signalosome: imaging the interactome.

Cannabinoid receptor 1 induces a biphasic ERK activation via multiprotein signaling complex formation of proximal kinases PKCɛ, Src, and Fyn in primary neurons.

Rapamycin forms an inhibitory complex with the FRB domain of mTOR and inhibits the kinase activities of mTOR protein (18, 19).

We therefore study functions of kinetochore proteins and spatio - temporal control of kinase / phosphatase signaling complexes, in particular those involved in attachment error - correction and the spindle assembly checkpoint.

Through interaction with the cdk / cyclin complexes, p21waf1 / cip1 modulates their kinase activity, resulting in cell growth arrest (10).

Kapoor P, Bao Y, Xiao J, Luo J, Shen J, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X. (2015) Regulation of Mec1 kinase activity by the SWI / SNF chromatin remodeling complex.

mTOR is a serine / threonine protein kinase that forms two distinct protein complexes within cells: one with the regulatory - associated protein of TOR (raptor) and another with the rapamycin - insensitive companion (rictor; refs.

Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X. (2015) Phosphorylation - Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex.

The mechanism by which rapamycin inhibits mTOR - raptor complex kinase activity is not completely understood.

Cell cycle is controlled by a set of protein complexes consists of cyclins and cyclin dependant kinases (CDKs) together provide the cell an orderly progression throughout the cycle [4].

The Raf ‐ 1 kinase inhibitor protein participates in the pathogenesis of IL ‐ 17 ‐ mediated autoimmune diseases and inflammation by promoting the formation of the IL ‐ 17RA ‐ Act1 complex, required for downstream signaling and cytokine production.

This is quite a complex pathway and I don't have time to go through details, but just briefly, glucose metabolism is regulated by insulin, so is lipid metabolism and this is one of many pathways where insulin activates a number of kinases, but particularly Akt.

Structure of the BRAF: MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

By Western blot analysis, we first examined whether the Janus - activated kinase (JAK)- STAT pathway — activated ISGF3 complex was involved in IFNα - induced RIG - G up - regulation.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Activated JAK kinases in turn phosphorylate - specific tyrosine motifs found in receptor domains, which then recruit the specific monomeric STATs to the receptor complex.

These effects are mediated at least in part via p38 MAP kinase, thereby providing multiple means for rapid control of Oct4 transactivation in response to complex extracellular stimuli throughout early development.

Cyclins form complexes with cyclin - dependent kinases (CDKs), unique to each cell - cycle phase, and activate specific genes to drive cells through their cycles.

AMPK (AMP - activated protein kinase) is a Ser / Thr kinase composed of two regulatory subunits and a catalytic subunit that together as a complex regulates the levels of energy in the cells.

Pathway and network analysis identifies systems with significantly enriched pSNVs, including kinase modules and protein complexes.

TORC1, Target of rapamycin complex 1; PI3K, Phosphoinositide 3 - kinase; SNARE, Soluble N - ethylmaleimide - sensitive factor Attachment protein REceptors.