Sentences with phrase «kinase enzymes»

Howard Hughes Medical Institute researchers have combed through a catalog of all known tyrosine kinase enzymes to identify new gene mutations that occur in a significant fraction of colon cancers...

We study the signal transduction pathways regulating cell growth and proliferation, with an emphasis on kinase enzymes.

It inhibits two tyrosine kinase enzymes called Jak1 and Jak2, which rev up production of immune cells.

The researchers found that the kinase enzymes have an impressive ability to confer resistance to many different macrolide antibiotics — the two enzymes that were studied in detail are essentially able to confer resistance to all macrolide antibiotics currently in use.

One option is an MEK inhibitor, which inhibits the mitogen - activated protein kinase enzymes used to therapeutically affect the MAPK pathway that is often overactive in cancers.

Metformin, which acts on the AMP kinase enzyme, lowers blood sugar and improves insulin sensitivity, thus altering insulin production.

HOT AND COLD Scientists reconstructed three billion years of genetic history for the adenylate kinase enzyme (shown here bound to another molecule) to see how ancient enzymes might have adapted to a cooler Earth.

Ginseng also helps your body to manage its production of what's called the kinase enzyme.

The kinase enzyme production in your body also kicks into overdrive when you've suffered a physical injury or severe pain and stress.

Creatine kinase enzyme is found in many of your pet's tissues; and some is always present free in its blood stream.

Not exact matches

New research from the University of Copenhagen's Department of Nutrition, Exercise and Sports reports that the enzyme AMP - activated protein kinase (AMPK) plays a crucial role in enhancing the ability of insulin to stimulate glucose uptake in muscles.

The animals lack the gene for an enzyme called inositol hexakisphosphate kinase 1 (IP6K1), which is known to play a role in fat accumulation and insulin sensitivity.

The authors also found that a novel small molecule inhibitor of the salvage pathway enzyme deoxycytidine kinase blocked leukemia growth in mice in combination with thymidine (to inhibit the de novo pathway).

The protein, known as focal adhesion kinase, or FAK, activates an enzyme called AKT, which helps islet cells in the pancreas to survive.

Cunningham and her postdoc at the time, Christine Kirvan, found that the antibodies literally bind to human neurons, activating an enzyme called calcium / calmodulin - dependent protein (CaM) kinase II.

This gene is one of many known to be involved in the formation of emotional memories, and encodes an enzyme called protein kinase C -.

And several attempts to carve a new target from a family of enzymes called p38 kinases have also failed, despite favorable results in animal models.

Researchers from St. Jude Children's Research Hospital have discovered that inhibiting an enzyme called cyclin - dependent kinase 2 (CDK2) protects mice and rats from noise - or drug - induced hearing loss.

Although the enzyme itself is inhibited in this state, it can be more easily re-activated through other tyrosine kinases.

Now, researchers at University of California San Diego School of Medicine and Harvard Medical School have found that the enzyme Protein Kinase C (PKC) alpha is necessary for amyloid beta to damage neuronal connections.

The target for ibrutinib, an enzyme called Bruton's tyrosine kinase (BTK), is a key component of B - cell receptor signaling.

But major pharmaceutical laboratories are investigating highly selective inhibitors of this molecular linchpin, many of them targeted at the enzymes (such as I - kB kinase) that regulate NF - kB activity.

Based on the current study results, the team believes a particular enzyme, «dual specificity tyrosine - regulated kinase - 1a (DYRK1A),» is the likely target of harmine.

When they found a good candidate that could deliver genes to rat brain cancer cells, they filled the nanoparticles with DNA encoding an enzyme, herpes simplex virus type 1 thymidine kinase (HSVtk), which turns a compound with little effect into a potent therapy that kills brain cancer cells.

Research has shown that glycogen synthase kinase (GSK) 3β is an enzyme that plays a major role in the development of AKI.

Crizotinib is a drug agent that takes aim at key enzymes within cells called kinases, which are often abnormal in cancer.

One reason may be that DDRs are protein enzymes known as tyrosine kinases that act as on and off switches of the cell self - cleaning process known as autophagy.

With this new understanding of the enzyme, called Inositol trisphosphate 3 - kinase B (ItpkB), scientists are closer to improving therapies for diseases such as bone marrow failure syndrome, anemia, leukemia, lymphoma and immunodeficiencies.

Some Alzheimer's researchers have cited evidence indicating that free - floating amyloid helps produce the corrupted p - tau via a chain of reactions that centers around GSK3 (Glycogen synthase kinase 3), an enzyme that arms tau with phosphorous, turning it into a potential biochemical assassin.

This particular liver cancer arises from a mutation that produces an abnormal form of the enzyme that is the topic of this current work, protein kinase A, and alters the enzyme's role in cell signaling.

When calcium floods a neuron as a memory is formed, it turns on an enzyme called CaMKII (calcium / calmodulin - dependent protein kinase).

In experiments using enzyme inhibitors, the possibility that cinnamtannin B - 1 enhanced mobilization through the use of activation of enzymes such as PI3 kinase near the cell membrane was shown.

To help on this front, in a new paper published in the journal Structure, researchers from McGill University present in atomic detail how specific bacterial enzymes, known as kinases, confer resistance to macrolide antibiotics, a widely used class of antibiotics and an alternative medication for patients with penicillin allergies.

They bond with a cysteine amino acid which only occurs in JAK3 — thereby blocking this enzyme but not the other Janus kinases.

They used one type of enzyme, called a kinase, to add phosphate groups — negatively - charged chemical components — to the peptides to neutralize their positive charge.

The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC - UNC), in partnership with the DiscoverX Corporation, has reached the milestone halfway point in its development of the Kinase Chemogenomic Set, a potent group of inhibitors which allow deeper exploration of the human kinome, a family of enzymes critical to understanding human disease and developing new therapies.

«A number of other types of tumors have been shown to be driven by chimeras, but this one is unique — it codes for a kinase, an enzyme that modifies other proteins, that has not been identified in cancers.»

The kinome, made up of enzymes called kinases, provides a tremendous opportunity for drug discovery.

Transmission of signals in a cell is controlled by the coordinated activity of two families of enzymes: protein tyrosine kinases, which add a phosphate group to proteins, and protein tyrosine phosphatases, which remove them.

The drug is a multi - kinase inhibitor (MKI)-- meaning it targets the specific enzymes that are required for growth in DTC.

Regorafenib is one of a new generation of anti-cancer therapies that attack tyrosine kinases — enzymes that activate other proteins.

Furthermore, the research revealed the part of the EMSY protein is changed by an enzyme called protein kinase A.

These phosphate groups are attached to proteins by enzymes known as kinases, while phosphatases act as their counterparts by removing them.

These tests revealed that an enzyme called Aurora kinase plays a key role in Stentor regeneration.

«We know dysregulation of a protein enzyme called multifunctional CaM kinase II plays a role in disrupting sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.

«If we find a kinase that regulates filopodial bridge formation or a kinase that facilitates virus surfing along a filopodium,» he says, these enzymes can be targeted to thwart infection.

In a proof - of - concept study, Fourches and Ash looked at the ERK2 kinase — an enzyme associated with several types of cancer — and a group of 87 known ERK2 inhibitors, ranging from very active to inactive.

In experiments with mouse and human hair follicles, Angela M. Christiano, PhD, and colleagues found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when directly applied to the skin.

To explore this question, the researchers examined the neurological impact of two enzymes that phosphorylate eIF2alpha, kinases termed PERK and GCN2, in different populations of AD model mice — all of which expressed genetic mutations akin to those carried by humans with AD.

But then Hayashi created a mouse with a mutation in a gene called PAK, which codes for an enzyme called p21 - activated kinase that helps build nerve connections in the brain.