Rho -
kinase inhibitor Y - 27632 (ROCKi) is a potential drug molecule, which has been reported to support the gene expressions typical for the chondrocytes, thus restricting their phenotypic conversion to fibroblastic cells upon the cellular expansion.
This thesis primarily investigates the effects of mechanical cyclic stretching, a 5 % low oxygen atmosphere and the Rho -
kinase inhibitor,
Y - 27632, on protein responses in chondrocytic human chondrosarcoma (HCS - 2 / 8) cells.
33) Gandhi J, Zhang J, Xie
Y, Shigematsu H, Soh J, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Garcia M, Minna JD, Gazdar AF (2009) Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine
kinase inhibitor sensitivity in lung cancer cell lines.