Sentences with phrase «kinase inhibitor p16ink4a»

Gonzales AJ, Bowman JW, Fici GJ, Zhang M, Mann DW, Mitton - Fry M. Oclacitinib (APOQUEL ®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy.

A blinded, randomized, placebo - controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel ®) in client - owned dogs with atopic dermatitis.

Multi-center, placebo - controlled, double - blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision.

PALLADIA belongs to the tyrosine kinase inhibitor (TKI) class of compounds.

«A Blinded Randomized Placebo - controlled Trial of the Efficacy and Safety of the Janus Kinase Inhibitor Oclacitinib (Apoquel ®) in Client - owned Dogs with Atopic Dermatitis» was designed in support of a new drug registration to evaluate the safety and efficacy of APOQUEL.

While considered as a Janus Kinase inhibitor or Jakinib, Apoquel (Oclacitinib) has certain specificity to the JAK - 1 enzyme.

Also, a 2012 study published on the Medical Journal 3 Biotech shows that the anti-cancer compounds in mushrooms play a crucial role as a reactive oxygen species inducer, mitotic kinase inhibitor, antimitotic, angiogenesis inhibitor, topoisomerase inhibitor all leading to apoptosis (cell death) and eventually checking cancer cell proliferation (4).

Clofibric acid, a well - known antihyperlipidemic drug, is reported to be a kinase inhibitor (18).

In particular, the upregulation of the cyclin - dependent kinase inhibitor p21Cip1 / WAF1 upon LA exposure was found to be required for its anticancer properties.

Following this comment, we examined the dependency of ROCK / myosin II in the LPA - mediated T cell motility in a collagen matrix and found that LPA - induced T cell motility was abrogated by the treatment of T - cells with blebbistatin or the Rho kinase inhibitor Y27632.

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.

Erlotinib, an EGFR tyrosine kinase inhibitor, has proven to be an effective agent in patients with mutations in the EGFR gene, but its efficacy in wild - type EGFR patients was unclear.

(B) Treatment of P19 cells with indicated nM concentrations of the p38 MAP kinase inhibitor SB202190 for 30 minutes, followed by western blotting.

Rydapt is a kinase inhibitor that works by blocking several enzymes that promote cell growth.

Overall stem cell colony formation efficiency following single cell isolation and flow cytometry was still quite low (∼ 0.5 %) despite the use of the Rho - associated kinase inhibitor but consistent results were obtained.

33) Gandhi J, Zhang J, Xie Y, Shigematsu H, Soh J, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Garcia M, Minna JD, Gazdar AF (2009) Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.

In particular, he is focused on studying therapeutic resistance to lapatinib, a tyrosine kinase inhibitor of HER2, in breast cancer.

244/2: 30 Functional correction of dwarfism in a mouse model of achondroplasia using the tyrosine kinase inhibitor NVP - BGJ398.

Similar results were obtained for the protein tyrosine kinase inhibitor regorafenib (data not shown).

Because of robust off - target effects of most RIPK2 inhibitors, we carried out molecular modeling (docking) and cheminformatics analyses by carefully analyzing the only known crystal structure of RIPK2 in association with the c - ABL kinase inhibitor ponatinib (https://www.rcsb.org/pdb/explore/macroMoleculeData.do?structureId=4C8B).

A low, non-genotoxic, dose (about 1 nM) of ActD has been shown to induce a reversible cytostatic effect in normal proliferating dermal fibroblasts and protect them from the aneuploidy induced by the aurora kinase inhibitor VX - 680 and the toxic effects of gemcitabine [46, 47].

Rao B, van Leeuwen IM, Higgins M, Campbel J, Thompson AM, Lane DP and Lain S. Evaluation of an Actinomycin D / VX -680 aurora kinase inhibitor combination in p53 - based cyclotherapy.

When the cells were treated with each kinase inhibitor individually, the applied kinase inhibitors themselves caused a minor induction of p53 expression (Fig. 5).

However, as proposed for the T790M mutation in the EGFR, 31 the significant gain - of - function property conferred by the mutations that we describe here may favor their initial presence before drug selection, and rapid selection during tyrosine kinase inhibitor - based therapy.

This signal can effectively be inhibited using RIPK2 inhibitors 1 and 2 and regorafenib (a known RIPK2 kinase inhibitor) at 100 nM as determined using RIPK2 phospho - specific antibodies (Fig. 4, A and B).

The first trial to take place as a result of the CDP initiative is a Phase I clinical trial of GlaxoSmithKline's aurora kinase inhibitor GSK - 1070916A - a promising new drug to treat solid tumours.

The major drawback of tyrosine kinase inhibitor therapy is the development of secondary resistance caused by the acquisition of new mutations.

The breakthrough led to a new type of cancer pharmaceutical, the tyrosine kinase inhibitor.

Senderowicz AM, Headlee D, Stinson SF, et al: Phase I trial of continuous infusion flavopiridol, a novel cyclin - dependent kinase inhibitor, in patients with refractory neoplasms.

The Raf ‐ 1 kinase inhibitor protein participates in the pathogenesis of IL ‐ 17 ‐ mediated autoimmune diseases and inflammation by promoting the formation of the IL ‐ 17RA ‐ Act1 complex, required for downstream signaling and cytokine production.

Patients with chronic myeloid leukemia in the blast phase pose a significant therapeutic challenge and have poor survival, even in the tyrosine kinase inhibitor era, according to a new study.

Additionally, we identified p21waf1 / cip1, a cyclin - dependent kinase inhibitor, as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression accounted for the colony - suppressing activity of DDX3.

Inhibition of Pulmonary and Skeletal Metastasis by a Transforming Growth Factor - β Type I Receptor Kinase Inhibitor

20) and several chemical drugs including mitogen - activated protein kinase inhibitor and histone deacetylase inhibitor (21, 22).

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

Differential effects of low - and high - dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.

mammalian target of rapamycin (mTOR); cyclin dependent kinase inhibitor - 2A

The study tested a lower dose of the oral multi-targeted tyrosine kinase inhibitor sunitinib than in previous trials, where toxicity proved too much of a problem.

A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine (AZA) or low - dose cytarabine (LDAC) is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.

Thus, alectinib has been developed and approved for use as an ALK kinase inhibitor.

Glennie et al 134 have shown that T cells stimulated in co-cultures with MSC exhibit an extensive inhibition of cyclin D2 and upregulation of the cyclin dependent kinase inhibitor p27kip1.

A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine or low - dose cytarabine is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.

Abrogation of the cell death response to oxidative stress by the c - Abl tyrosine kinase inhibitor STI571.

We have specifically studied the potential of endothelial differentiation of MSC and the impact of a tyrosine kinase inhibitor (Imatinib mesylate) on this type of stem cells.

Tan Z, Chen L, Zhang S. Comprehensive modeling and discovery of mebendazole as a novel TRAF2 - and NCK - interacting kinase inhibitor.

Scanning electron micrograph of the coronary microvasculature of a mouse that has been treated with a small molecule tyrosine kinase inhibitor of platelet - derived growth factor receptor beta.

PHIb Trial of Fulvestrant, Palbociclib (CDK4 / 6 inhibitor) and Erdafitinib (JNJ - 42756493, pan-FGFR Tyrosine Kinase Inhibitor) in ER + / HER2 - / FGFR - amplified Metastatic Breast Cancer (MBC)

In 2005, Cagan's team created a general fly model of a human thyroid tumor caused by mutations in the Ret receptor tyrosine kinase gene, then screened a panel of drugs including a kinase inhibitor called vandetanib that suppressed the tumor (Cancer Res, 65:3538 - 41, 2005).

This thesis primarily investigates the effects of mechanical cyclic stretching, a 5 % low oxygen atmosphere and the Rho - kinase inhibitor, Y - 27632, on protein responses in chondrocytic human chondrosarcoma (HCS - 2 / 8) cells.

Rho - kinase inhibitor Y - 27632 increases cellular proliferation and migration in human foreskin fibroblast cells