Sentences with phrase «kinase pathway»

The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Amyloid - beta oligomers through Tau phosphorylation on S262.
LKB1 - NUAK1 kinase pathway regulates terminal axon branching through mitochondrial trafficking.
Mairet - Coello G, Courchet J, Pieraut S, Courchet V, Maximov A and Polleux F. (2013) The CAMKK2 - AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Abeta Oligomers through Tau Phosphorylation.
Role of the p38 Mitogen - Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide — Dependent Cellular Responses
She joined the Polleux lab in 2014 and studies the role of the AMPK - ULK kinase pathway in Alzheimer's Disease.
Cyclotherapy may be achieved by combining ActD treatment with other drugs [17, 18], and therefore understanding the cellular kinase pathway for the drugs used in combination treatment will be valuable for future cyclotherapy studies.
«So a cell that rewires its metabolism early on to scarf up nutrients from the environment is more likely to do what the tyrosine kinase pathway sets in motion; it's more likely to have all the things it needs to become a tumor.»
Courchet J. *, Lewis T. Jr *, Aizawa S. and Polleux F. (2013) Terminal axon branching is regulated by the LKB1 - NUAK1 kinase pathway via presynaptic mitochondrial capture.
Additional studies by the team suggested that the toxin blocks a vital signaling route called the MAP kinase pathway within the dendritic cells.
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.
We are currently identifying the downstream effectors of this CAMKK2 - AMPK kinase pathway including Tau and some key effectors of autophagy.
One of the relatively new findings is the recurrence of mutations in MAP3K1, a serine - threonine kinase that activates the ERK and JNK kinase pathways.
Metlakunta AS, Sahu M, Sahu A. Hypothalamic phosphatidylinositol 3 - kinase pathway of leptin signaling is impaired during the development of diet - induced obesity in FVB / N mice.
Initiation of dopaminergic differentiation of Nurr1 -LRB--) mesencephalic precursor cells depends on activation of multiple mitogen - activated protein kinase pathways.
Mairet - Coello G., Courchet J., Pierault S., Courchet, V., Maximov A., Polleux F. (2013) The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers in vivo through Tau phosphorylation.
By analysing skin biopsies post-injection, the researchers found that the excessive inflammation was associated with activation of the p38 MAP kinase pathway.
Mairet - Coello G. and Polleux F. (2014) Involvement of «stress - response» kinase pathways in Alzheimer's disease progression.
The researchers, from Kings College London, also found evidence of a close relationship between PAK4 and a well - researched cancer pathway called the phosphoinositide 3 - kinase pathway (PI3K).
More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway — a key signaling pathway that controls cell proliferation.
Mekinist and Tafinlar are used to block signaling in different sites of the same molecular pathway — the MAP kinase pathway.
Western blot analyses with phospho - specific antibodies suggested that stretching induces phosphorylation of ERK of the MAP kinase pathway, but did not induce phosphorylation of phosphatidylinositol 3 - kinase.
In the last decade the identification of genetic drivers of melanoma cell which regulate proliferation and survival - such as BRAF and other activators of the MAP - kinase pathway - along with the recent development of immunotherapy has taken away in many cases the invasive treatment of melanoma as an option.
But this gives you a good overview of two major pathways that are regulated by insulin: one is called the metabolic pathway, or the PI - 3 kinase pathway; and the other is the mitogenic pathway, or the MAP kinase pathway.
The present study analyzed the kinase pathway through which ActD induces p53, and found that AKT was phosphorylated and activated by ActD.
Although it has been reported that ActD induces p53 expression, the kinase pathway for ActD - induced p53 has not been identified.
We were interested in analyzing whether any kinase pathway mediated ActD - induced p53 expression and phosphorylation.
Although low doses of ActD have been studied in p53 base cyclotherapy, the kinase pathway by which ActD induces p53 has not been examined.
Berberine improves insulin signal transduction by stimulating glucose intake via the activation of the AMP - activated protein kinase pathway.
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