Sentences with phrase «kinase pathway in»

She joined the Polleux lab in 2014 and studies the role of the AMPK - ULK kinase pathway in Alzheimer's Disease.

Role of the p38 Mitogen - Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide — Dependent Cellular Responses

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In contrast, HPV - inactive tumors often have mutations in the PIK3CA / PTEN / AKT pathway, indicating that AKT kinase inhibitors may be effective treatment options for these patients.&raquIn contrast, HPV - inactive tumors often have mutations in the PIK3CA / PTEN / AKT pathway, indicating that AKT kinase inhibitors may be effective treatment options for these patients.&raquin the PIK3CA / PTEN / AKT pathway, indicating that AKT kinase inhibitors may be effective treatment options for these patients.»

The authors also found that a novel small molecule inhibitor of the salvage pathway enzyme deoxycytidine kinase blocked leukemia growth in mice in combination with thymidine (to inhibit the de novo pathway).

Researchers from the «Angiogenesis signaling pathways» research group of the Institute of Biomedical Investigation of Bellvitge (IDIBELL), led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3 - kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs).

In his research, Juha Piltti has focused on a small molecule, which causes Rho - kinase inhibition and regulation of specific down - stream protein pathways involved in many physiological processeIn his research, Juha Piltti has focused on a small molecule, which causes Rho - kinase inhibition and regulation of specific down - stream protein pathways involved in many physiological processein many physiological processes.

In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - FoIn this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Foin a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Researchers found that genetically disrupting this pathway, or using the FDA - approved Src kinase inhibitor dasatinib, increases PUMA levels and decreases tumor progression and metastasis in mice by up to fivefold.

Several years ago, researchers found that 80 percent of patients with uveal melanoma had mutations to GNAQ or GNA11, genes that activate signals in the mitogen - activated protein kinase (MAPK) pathway.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

One option is an MEK inhibitor, which inhibits the mitogen - activated protein kinase enzymes used to therapeutically affect the MAPK pathway that is often overactive in cancers.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

Astonishingly, sphingosine -1-phosphate is only released in the macrophages if — alongside with the binding of dimer - GR to the DNA — a pro-inflammatory signalling pathway is stimulated involving protein kinases p38 and MSK1.

«For example, restoring the lost enzymes in the two metabolic pathways might slow tumor progression and reduce aggressiveness by inactivating oncogenic kinases and activating immune responses,» says Chakravarti, who holds the Max Morehouse Chair in Cancer Research.

«We started at the mTORC1 kinase and are building the pathway up piece by piece to identify who is talking to whom in the pathway and to understand how each of those proteins is relaying information about the availability of nutrients in the cell.»

Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic ß - Cells Is Inhibited by Unsaturated Oleic Acid.

Wang, H, Gai, Q, Yang, X, Li, Z, Linders, B, Santoro, S, Zutter, M. Role of the a1 and a2 integrin cytoplasmic domains in cell morphology, motility and responsiveness to stimulation by the protein kinase C pathway.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity - dependent manner through a protein kinase C - dependent pathway.

Apolipoprotein (a), through Its Strong Lysine - binding Site in KIV10, Mediates Increased Endothelial Cell Contraction and Permeability via a Rho / Rho Kinase / MYPT1 - dependent Pathway.

In the last decade the identification of genetic drivers of melanoma cell which regulate proliferation and survival - such as BRAF and other activators of the MAP - kinase pathway - along with the recent development of immunotherapy has taken away in many cases the invasive treatment of melanoma as an optioIn the last decade the identification of genetic drivers of melanoma cell which regulate proliferation and survival - such as BRAF and other activators of the MAP - kinase pathway - along with the recent development of immunotherapy has taken away in many cases the invasive treatment of melanoma as an optioin many cases the invasive treatment of melanoma as an option.

Tobias Heckel (Hoflack, TUD)-- «Revealing Src tyrosine kinase - dependent signaling pathways in osteoclasts: Implications on actin organization and cell polarity» (2008)

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP - 2, and β - catenin.

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

Regulation of heme oxygenase - 1 expression by demethoxy curcuminoids through Nrf2 by a PI3 - kinase / Akt - mediated pathway in mouse β - cells.

In this new paper, the researchers reveal more about that mechanism, showing that without the protective ability of BRCA1, breaks in the DNA strands go unfixed, prompting the molecule ATM kinase to activate a cellular «suicide» pathway involving a protein called p5In this new paper, the researchers reveal more about that mechanism, showing that without the protective ability of BRCA1, breaks in the DNA strands go unfixed, prompting the molecule ATM kinase to activate a cellular «suicide» pathway involving a protein called p5in the DNA strands go unfixed, prompting the molecule ATM kinase to activate a cellular «suicide» pathway involving a protein called p53.

[48] Mutations in GNAQ or GNA11 occur in the majority of uveal melanomas and drive oncogenesis via activation of the phospholipase C / protein kinase C (PKC), Rho / Rac, and Yes - associated protein pathways.

These receptors have been used in bacterial biosensors, where re-designed PBPs were linked to gene expression through a histidine kinase signaling pathway [5].

Activation of Mammalian Target of Rapamycin Signaling Pathway Contributes to Tumor Cell Survival in Anaplastic Lymphoma Kinase — Positive Anaplastic Large Cell Lymphoma

One of the relatively new findings is the recurrence of mutations in MAP3K1, a serine - threonine kinase that activates the ERK and JNK kinase pathways.

The basal and B - RAF - stimulated kinase activities of a third variant are unaltered but its activation by RAS is significantly reduced, suggesting that it may act in a dominant - negative manner to modulate pathway signaling.

Pathways involved in inflammation, glycan metabolism, cancer, Wnt signaling, and mitogen - activated protein kinase signaling were among those significantly enriched (Fig. 2J and Supplementary Table 13).

Title: A genome - wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation (IN PRESS, Oct 2012) Authors: Sharrocks A, Yang S - H, Kalkan T, Haslam C, Smith A Date: IN PRESS, Oct 2012 Publication Details: PLoS Genetics

GSK3 (Glycogen Synthase Kinase - 3) is a signaling mediator involved in a variety of different signaling pathways including WNT, growth factors, insulin, and Hedgehog pathways.

Metlakunta AS, Sahu M, Sahu A. Hypothalamic phosphatidylinositol 3 - kinase pathway of leptin signaling is impaired during the development of diet - induced obesity in FVB / N mice.

[41] Approximately 50 % of cutaneous melanomas have an activating BRAF mutation, with an additional 10 % to 20 % having an activating mutation in NRAS; NRAS is an upstream partner of BRAF that also activates the phosphatidylinositol 3 - kinase (PI3K) / Akt / mammalian target of rapamycin (mTOR) pathway.

«So a cell that rewires its metabolism early on to scarf up nutrients from the environment is more likely to do what the tyrosine kinase pathway sets in motion; it's more likely to have all the things it needs to become a tumor.»

Mairet - Coello G., Courchet J., Pierault S., Courchet, V., Maximov A., Polleux F. (2013) The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers in vivo through Tau phosphorylation.

In the cytoplasm, lethal toxin is a zinc metalloprotease that cleaves a number of identified proteins, including members of mitogen - activated protein kinase (MAPK) signaling pathways [33] and the inflammasome - activating sensor NLRP1B [34].

In addition to inhibiting STAT5 signaling, we found that depletion of ABL kinases decreased the expression of the Hippo pathway mediator TAZ and downstream target genes in triple - negative and HER2 + breast cancer cellIn addition to inhibiting STAT5 signaling, we found that depletion of ABL kinases decreased the expression of the Hippo pathway mediator TAZ and downstream target genes in triple - negative and HER2 + breast cancer cellin triple - negative and HER2 + breast cancer cells.

Interestingly, PDGF - BB overexpression by modified hDPSCs enhanced the recruitment of hDPSCs both in vitro and in vivo via the activation of the phosphatidylinositol 3 kinase (PI3K) / Akt signaling pathway and, in combination with secreted vascular endothelial growth factor (VEGF), enhanced in vitro angiogenesis.

To evaluate whether the TAZ and STAT5 pathways promote breast cancer bone metastasis downstream of the ABL kinases, we expressed the constitutively active mutants TAZ S89A and STAT5 * in ABL1 / ABL2 knockdown cells.

ABL kinases regulate the expression of genes in the JAK / STAT and Hippo pathway signatures in metastatic breast cancer cells.

This is a very important lipid, that actually is involved in signaling, to many other kinases, and the key kinase that through this pathway gets activated is Akt; and Akt is a very important kinase that regulates many other factors.

We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.

The allosteric inhibitors specific for ABL kinases (which are currently in clinical trials) provide a potentially useful tool for selectively targeting ABL kinases in metastatic breast cancer types with an increase in the ABL pathway signature (58).

Here, we uncovered a role for the ABL kinases in promoting breast cancer bone metastasis through the regulation of distinct pathways required for tumor colonization and survival in the bone microenvironment.

MEK1 / 2 and MKK3 / 6 are MAPK kinases upstream of several MAPK pathways, including ERK1 / 2 and p38, respectively, and have well described roles in many immune cells [48], but this has not been studied in IL -23-stimulated ILC3s.

Further, inactivation of the ABL kinases resulted in decreased expression of the genes in the Hippo, Janus kinase (JAK) / STAT, and cytokine / cytokine receptor pathway signatures (Fig. 6B).