Sentences with phrase «kinase pathway mediates»

Mairet - Coello G., Courchet J., Pierault S., Courchet, V., Maximov A., Polleux F. (2013) The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers in vivo through Tau phosphorylation.

Mairet - Coello G, Courchet J, Pieraut S, Courchet V, Maximov A and Polleux F. (2013) The CAMKK2 - AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Abeta Oligomers through Tau Phosphorylation.

The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Amyloid - beta oligomers through Tau phosphorylation on S262.

Not exact matches

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

Apolipoprotein (a), through Its Strong Lysine - binding Site in KIV10, Mediates Increased Endothelial Cell Contraction and Permeability via a Rho / Rho Kinase / MYPT1 - dependent Pathway.

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP - 2, and β - catenin.

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

Regulation of heme oxygenase - 1 expression by demethoxy curcuminoids through Nrf2 by a PI3 - kinase / Akt - mediated pathway in mouse β - cells.

At the cellular level, p53 can either induce senescence or, of major interest here, inhibit senescence by controlling both reactive oxygen species (ROS) levels and a signaling pathway mediated by protein kinases AMPK and mammalian target of rapamycin (mTOR).

More recently, we elucidated an additional mechanism of tumor suppression mediated by canonical ephrin - induced EphA2 signaling (Figure 1A), which leads to inhibition of the AKT - mTORC1 oncogenic pathway through interplay of EphA2 with a phosphatase that dephosphorylates the AKT serine / threonine kinase.

In addition, our data evidence that LA via the Rho - associated kinase - mediated pathway promotes stress fiber formation, which exerts a main role in the morphological changes associated with apoptotic cell death.

[1] DIM was found to have «lung cancer preventive effects» mediated via modulation of the receptor tyrosine kinase / PI3K / Akt - signaling pathway.

It has recently been reported that insulin resistance causes a down - regulation of adiponectin receptors [10], which may be mediated by PI3 - kinase / FOXO1 dependent pathway [10].