Fatty acids differentially influence phosphatidylinositol 3 -
kinase signal transduction in endothelial cells: impact on adhesion and apoptosis.
The p38 MAP
kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation.
We show that evolutionarily conserved histidine
kinase signal transduction components [9], [10], [11] can be used to build a synthetic signal transduction system, and we then use this system to link input from computationally re-designed receptors to a plant response.
Not exact matches
During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of
signal transduction, in particular how receptor tyrosine
kinases are activated to transmit their
signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.
In 1995, I began graduate studies on
signal transduction by growth factors and receptor tyrosine
kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.
I studied the process called
signal transduction - transmission of the activating mechanical
signal from outside the cell, across the cellular membrane, to FAK inside the cell, leading to the activation of the
kinase.
Signal transduction through the T - lymphocyte CD4 receptor involves the activation of the internal membrane tyrosine - protein
kinase p56lck.
Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP
kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis,
signal transduction molecules, and transcription factors.
We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine
kinase)
signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic
signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.
The work was also highlighted in the Editors» Choice section in the online journal Science STKE (
Signal Transduction Kinase Expression).
Recently, interest has developed regarding the possibility of targeting intracellular inhibitory proteins to improve T cell activity against cancer, including diacylglycerol
kinase ζ (DGKζ)(9, 10) and Casitas b - lineage proto - oncogene b (Cbl - b)(11), which attenuate
signal transduction events downstream of the TCR and CD28.
Diagram of the complete synthetic
signal transduction system in transgenic plants, using TNT as the ligand,
signaling through the bacterial chimeric histidine
kinase, and adapted response regulator, then activating a transcriptional response.
We study the
signal transduction pathways regulating cell growth and proliferation, with an emphasis on
kinase enzymes.
Vorinostat interferes with the
signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3
kinase inhibitors in cutaneous T - cell lymphoma
In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine
kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine
kinase family comprising three other mammalian non-receptor tyrosine
kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic
kinase activity to mediate cytokine - induced
signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine
kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with
kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10
Death - associated protein
kinase (DAPK) and
signal transduction: fine - tuning of autophagy in Caenorhabditis elegans homeostasis.
Berberine improves insulin
signal transduction by stimulating glucose intake via the activation of the AMP - activated protein
kinase pathway.