Sentences with phrase «kinetochores in»

In Harrison's lab, Corbett solved the structure of monopolin, a complex that binds kinetochores in meiosis I to modify their behavior.

Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle.

Not exact matches

Biologists who study the mechanics of cell division have for years disagreed about how much force is at work when the cell's molecular engines are lining chromosomes up in the cell, preparing to winch copies to opposite poles across a bridge - like structure called the kinetochore to form two new cells.

CENP - meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila.

Modular elements of the TPR domain in the Mps1 N terminus differentially target Mps1 to the centrosome and kinetochore.

We therefore study functions of kinetochore proteins and spatio - temporal control of kinase / phosphatase signaling complexes, in particular those involved in attachment error - correction and the spindle assembly checkpoint.

Kinetochores are extremely complex assemblies of > 100 proteins in hundreds of copies, bound to centromeric DNA sequences.

He completed his master's in biotechnology at the University of Pennsylvania, where he worked in Michael Lampson's lab studying microtubule — kinetochore dynamics during mitosis.

Csm1 point - mutations that disrupt kinetochore - subunit binding also disrupt sister chromatid co-orientation in S. cerevisiae meiosis I.

The monopolin complex regulates different types of kinetochore - microtubule attachments in fungi, ensuring sister chromatid co-orientation in Saccharomyces cerevisiae meiosis I and inhibiting merotelic attachment in Schizosaccharomyces pombe mitosis.

Therefore, physical force at the kinetochore is diffused and inefficiently transmitted to chromosomal arm regions, resulting in chromosomal segregation defects in condensin mutant.