Further studies showed that Notch1
knockdown in NSCLC helps induce cell death (which inhibits tumor initiation and growth); this process is mediated by p53, and thus the effects of inhibiting Notch1 require functional p53.
(A, B) GBP1, GBP2 double -
knockdown in the fat body reduces final body size in females (A) and males (B).
n = 35 — 65 for A and n = 21 — 56 for B. (C) GBP1, GBP2 double -
knockdown in the fat body reduces growth rate.
(A, B) GBP1, GBP2 double -
knockdown in the fat body increases ilp2 expression (A) but reduces ilp5 expression (B).
Further studies of ALN - TTR02 are needed to examine the clinical efficacy and safety of long - term transthyretin
knockdown in patients with familial amyloidotic polyneuropathy.
«What we're excited about is how it only takes a very small amount of RNA to cause gene
knockdown in the whole liver.
«We developed Drosophila lung cancer models by targeting Ras alone and in combination with PTEN
knockdown in the tracheal system of the fruit fly,» says Cagan, PhD, Professor in the Department of Developmental & Regenerative Biology, Senior Associate Dean of the Graduate School of Biomedical Sciences, and Director of the Center for Personalized Cancer Therapeutics at Icahn School of Medicine at Mount Sinai.
Berchelt finished the job after the second
knockdown in connecting with several hard...
Think of it as setting up the dominoes before the effortless
knockdown in the morning.
A minute later, Raheem Sterling and Henderson got in each others» way while trying to convert Harry Maguire's
knockdown in the area, but the English pressure soon told.
Cesar Azpilicueta, a surprisingly consistent threat in the penalty box at set pieces today, prodded home from Morata's
knockdown in the aftermath of a corner kick to provide Chelsea with a 36th - minute lead.
Like two prized fighters, these two giants of European football sized each other up with gentle jabs before Robin Van Persie delivered
a knockdown in the 78th minute.
Joe Allen slid in to score from a Christian Benteke
knockdown in the first half, before Gomes failed to save a routine Firmino shot in the second 45.
Stoke's goal resulted from a goalkeeping error by Adam Federici; Michael Kightly won the second ball from
a knockdown in the penalty area, and, from the middle of the box, hit a soft dipping shot to Federici's near post.
After two
knockdowns in a round, a sensible fighter would have considered the possibility of a third looming up, and would have elected to stay out of trouble.
Over DePaula's floundering form last week he made it 25 KOs, though this last one was only technically a knockout, made mandatory by the New York boxing commission rule that, even in a championship bout, after three
knockdowns in a round a fighter is automatically disqualified, supposedly to prevent serious injury.
Not exact matches
After that first
knockdown by Foreman
in the 1973 bout, the champ got his mandatory eight count and then returned to his feet.
Frieden said aerial spraying continues to be successful
in the Wynwood neighborhood, where experts have seen «substantial but not complete
knockdowns of mosquito populations.
The steep fall
in 2012 - 2013 has many possible causes, including the heated presidential elections and the
knockdown, drag - out budget battles that culminated
in last year's government shutdown.
It's an easy victory
in each of the first three rounds, but there hasn't been a
knockdown yet.
Brock started running
in the»60s, when stealing indiscriminately was punishable by
knockdown pitches or other retaliatory tactics.
relax guys wenger is saying that so he can get a good deal
in the market.if people think we arent desperate we can shop at
knockdown prices bla bla bla..
i think if we by any chance got griezmann that would be awesome, against bus parking teams like norwich we could play with a top 2 with griezmann and giroud they can play very well with eachother and griezmann could get on to girouds flicks and
knockdowns and griezmann does play
in a top2 at atletico and against the most teams griezmann could play as a lone striker, but anyway i do nt think he will leave atletico
Randy Turpin, England's former world middleweight champion, called it quits after unsungCanadian light heavyweight Gordon Wallace scored four
knockdowns, knocked himout
in fourth round at London.
There,
in a fight like this, the decision goes to the fighter who gets the
knockdown.»
«Someone said it was the greatest dropped pass of all time, but it wasn't; it was a
knockdown,» he said as he lobbied for his place
in Michigan history while signing autographs
in the stadium parking lot after the game.
Giroud is a target that works well with players that follow the ball and are
in the general vicinity for his
knockdowns.
Mertesacker 6.5 — Apart from looking frozen
in time on the first goal the big German defended well and was a calming presence and his
knockdown should have been an assist.
DePaula had indeed gone to the canvas three times
in that first round — and Foster had been down once — but there was a dubiousness about a couple of what Referee Johnny LoBianco ruled were true
knockdowns and not slips.
Brunson thrived
in the post and Spellman dropped 50 pounds since graduating high school to turn into a
knockdown shooter at center.
Ten potential bargains available
in this summer's transfer window, including big names at
knockdown prices, plus four free agents who could be moving between rival clubs...
OG is the best set piece player
in the league and creates chances with his
knockdowns to players.
Porto took the lead with little more than 10 minutes left, as Joao Mario capped of a fast counterattack to leave Chelsea on the brink of elimination, but Josh Grant levelled
in the 86th minute when he fired
in from Trevoh Chalobah's
knockdown after a Juan Castillo corner.
Marseille came within a whisker of taking the lead
in the 42nd minute, Sarr hitting the woodwork with a scrappy volley from Mitroglou's
knockdown, only to find themselves behind at the break.
Gerrard himself slammed home an equaliser from a Peter Crouch
knockdown with nine minutes of the second half played, but just past the hour mark future Liverpool left - back Paul Konchesky watched his lofted cross sail over Pepe Reina and into the Reds goal to put the Irons back
in the lead.
Look at the work Arsenal forward Olivier Giroud does
in the buildup, drawing both defenders and then assisting Griezmann with a perfect
knockdown header
Forward Bamba fired Cheikh Ndoye's
knockdown into the bottom corner
in the fifth minute and Angers held on to make it back - to - back league wins.
In the past Chelsea have paid special attention to winning his
knockdowns, it being near impossible to beat him to a high ball.
Grant's cross from the left found Sterling
in the box and the wideman's
knockdown was swept
in from close range by the alert Brown.
Sanchez will have entered the final six months of his contract
in the New Year, and this could potentially see them accept a
knockdown price for the Chilean to push through a move for Lemar.
Just as he's pushing through # 12bn of welfare cuts which will hit the poorest and most vulnerable
in society, Osborne wants to sell the taxpayer - owned bank back to his friends
in the City at
knockdown prices, losing taxpayers at least an eye - watering # 13bn.
They could buy shares
in privatised utilities for a
knockdown price and make a quick killing.
In one documented by the Africa Progress Panel, mining rights in the Democratic Republic of Congo were sold for knockdown prices in deals that involved a series of secretly - owned firms in the BVI, leaving it unclear who had benefited from what may have been corrupt deal
In one documented by the Africa Progress Panel, mining rights
in the Democratic Republic of Congo were sold for knockdown prices in deals that involved a series of secretly - owned firms in the BVI, leaving it unclear who had benefited from what may have been corrupt deal
in the Democratic Republic of Congo were sold for
knockdown prices
in deals that involved a series of secretly - owned firms in the BVI, leaving it unclear who had benefited from what may have been corrupt deal
in deals that involved a series of secretly - owned firms
in the BVI, leaving it unclear who had benefited from what may have been corrupt deal
in the BVI, leaving it unclear who had benefited from what may have been corrupt deals.
The team confirmed that genetic «
knockdown» of PRMT1 significantly impaired PDAC cell growth
in vitro through use of genetic editing tools, including CRISPR and small hairpin RNA (shRNA).
Further experiments confirmed that
knockdown of this protein
in IPF fibroblasts diminished the collagen synthesis.
The big
knockdown fight
in science these days is a debate about a cataclysm that occurred 250 million years ago
The researchers were surprised to find that
knockdown of one specific mitochondrial chaperone, mtHSP70, elicited a unique stress response mediated by fat accumulation, resulting
in improved protein folding
in the interior or cytosol of the cell.
Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role
in the development of the lung, as well as other tissues controlled by this pathway.
«If the gene has been blocked
in a
knockdown, blood vessels do not develop normally,» explains Andrea Rossi, together with Zacharias Kontarakis first author of the study.
In contrast, in a «gene knockdown» scientists block protein production using particular substances, e.g. microRNA
In contrast,
in a «gene knockdown» scientists block protein production using particular substances, e.g. microRNA
in a «gene
knockdown» scientists block protein production using particular substances, e.g. microRNAs.