Sentences with phrase «knockin mice»

Role of VGF - derived carboxy - terminal peptides in energy balance and reproduction: analysis of «humanized» knockin mice expressing full - length or truncated VGF.

These data suggest that increased inhibitory synaptic transmission may contribute to human ASDs and that the R451C knockin mice may be a useful model for studying autism - related behaviors.

To investigate the role of cleavage in vivo, we generated by gene targeting a Pkd1 knockin mouse (Pkd1 (V / V)-RRB- that expresses noncleavable PC1.

Disease progression was compared in three knockin mouse lines with similar CAG repeat expansion lengths of approximately 190 repeats, were compared at 2, 4, 6 and 10 months of age utilizing PsychoGenics proprietary cubes platform technologies: PhenoCube ®, Smart Cube ® and Neurocube ® as well as standard behavioral testing paradigms including Open Field and Tapered Balance Beam.

Reconstruction of transgenic and gene knockout and knockin mouse models of human diseases.

Not exact matches

We generated knockin / knockout mice that expressed only open syntaxin - 1B.

The Y141C knockin mutation in RDS leads to complex phenotypes in the mouse.

Development of innovative mouse lines by targeted genome modification (knockin - knockout (KI / KO) approaches).

Using knockin point mutations in mice, Dr. Rudolph has demonstrated that anxiolytic and sedative actions of benzodiazepines, such as diazepam (Valium), are mediated by two distinct GABAA receptor subtypes and can thus be targeted separately pharmacologically.

Given that many recent studies of B cell biology take advantage of Ig - transgenic (or knockin equivalent) mice for their entire analysis, we do not feel that our use of the approach as one part of the present study is out of line with currently accepted practice in the field.