Transgenic and gene knockout /
knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.
Disease progression was compared in three
knockin mouse lines with similar CAG repeat expansion lengths of approximately 190 repeats, were compared at 2, 4, 6 and 10 months of age utilizing PsychoGenics proprietary cubes platform
technologies: PhenoCube ®, Smart Cube ® and Neurocube ® as well as standard behavioral testing paradigms including Open Field and Tapered Balance Beam.