If the GH
knockout Mice lived longer when being given exogenous GH would that be evidence of another, poorly understood receptor for GH?
Although the Nppb -
knockout mice lived a normal lifespan, when the researchers killed the receptor cells in the spinal cord, the mice died prematurely, suggesting that it could be dangerous to try humans, Hoon says.
Not exact matches
The
knockout mice and the healthy littermates will both undergo a battery of more than 400 phenotype measurements at multiple times during their
lives.
Adenylyl Cyclase Type 5 (AC5):
Knockout of AC5 extends
life in
mice, with the most plausible mechanism being increased resilience of the cardiovascular system to the various slings and arrows of aging.
When researchers express interest in obtaining a certain
knockout mouse line, the repositories will send them
live mice, frozen embryos, sperm, and / or ES cells, so they can study the
mice in their own labs.
TRPV1: Gene
knockout of the pain receptor TRPV1 is one of a number of methods of slowing aging and extending
life in
mice that appears to work through altered insulin signaling.