Sentences with phrase «knockout mice as»

The team conducted a multi-disciplinary research composed of scientific techniques, computational modeling and having knockout mice as the subject to see the concealed mechanism of sleep.

Body composition was unaltered in Lyplal1 knockout mice as assessed by Dual - energy X-ray absorptiometry (DEXA) scanning, both on normal chow and on a high fat diet.

Not exact matches

I hope wenger does not take it as MICKEY MOUSE CUP VERSION - 2 and keep playing the kids coz we may be really embarrassed in the knockout stages in europe, especially against the likes of the above mentioned teams and a.c.milan, lazio etc... who are in a descent form in this competition so far...

As they studied brain activity in the knockout mice, the researchers also found prominent changes in a receptor in the brain known as mGluR5 and other proteins that support the function of neurons and synapses, said co-lead author Xiaoming Wang, M.D., Ph.D., senior research associate in Duke's department of pediatricAs they studied brain activity in the knockout mice, the researchers also found prominent changes in a receptor in the brain known as mGluR5 and other proteins that support the function of neurons and synapses, said co-lead author Xiaoming Wang, M.D., Ph.D., senior research associate in Duke's department of pediatricas mGluR5 and other proteins that support the function of neurons and synapses, said co-lead author Xiaoming Wang, M.D., Ph.D., senior research associate in Duke's department of pediatrics.

Currently, it takes up to 10 months — and as much as $ 100,000 — to develop a knockout mouse strain.

«The next thing to do is to generate a knockout mouse model for further in vivo analysis, as the ultimate goal of our research is to move from bench to bedside, and generating a mouse model is a key step during this long journey,» Shi said.

As expected, gp96 knockout mice grew normally at first.

The team then administered progesterone inhibitors to normal mice and found that the animals behaved much as their knockout counterparts did.

When these knockout mice were fed a high - fat diet, they gained as much weight as normal mice did, but they managed to remain sensitive to insulin.

That egg might develop as a normal mouse or a knockout.

On the other hand, as they aged, these «knockout mice» grew fatter than the normal mice, especially when fed a high - fat diet.

The first group was mice with targeted deletion of the interleukin 10 (IL10) gene, known as interleukin 10 knockout (IL10 - / --RRB- mice, which develop colitis through T helper immune cells.

The fact that Connexin 30 knockout mice had a higher number of grafted cells than normal mice, and that some of the grafted cells expressed CONNEXIN 30 is a very important finding when considering cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency.

As in earlier studies, the investigators, led by Ren Hen of Columbia University, first created a line of so - called knockout mice that lacked the gene encoding the receptor protein.

«The one thing that I think that is useful is maybe when people write knockout papers they might describe the housing conditions in more detail,» says Chris Paszty, scientific director at the biotech company Amgen, Inc., headquartered in Thousand Oaks, Calif., who as a postdoctoral researcher at Lawrence Berkeley National Laboratory developed a mouse model for the study of sickle cell anemia.

It is now possible to introduce mice strains (known as «knockout mice») in which specific genetic modifications can be activitated at specific times, or in specific cells or organs.

The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

The endothelial cells in insulin - receptor knockout mice expressed more of the VCAM - 1 adhesion molecule that helps white blood cells grab onto the growing plaques, and blood vessels gathered four times as many white blood cells.

Some mouse strains are only archived as knockout - first allele («tm1a allele»), but if users are interested in another allele which is not cryopreserved at EMMA, some EMMA nodes offer allele conversion as a service.

Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.

* Many genetically altered mice are already available «off the shelf» as part of the International Knockout Mouse / Mouse Phenotyping Consortium.

The mouse clinics participating in INFRAFRONTIER all contributed to major European phenotyping projects such as the European Mouse Disease Clinic (EUMODIC) project, the first internationally coordinated large scale phenotyping effort, which produced and phenotyped 500 IKMC knockout mouse lmouse clinics participating in INFRAFRONTIER all contributed to major European phenotyping projects such as the European Mouse Disease Clinic (EUMODIC) project, the first internationally coordinated large scale phenotyping effort, which produced and phenotyped 500 IKMC knockout mouse lMouse Disease Clinic (EUMODIC) project, the first internationally coordinated large scale phenotyping effort, which produced and phenotyped 500 IKMC knockout mouse lmouse lines.

These knockout mice, together with the wealth of associated data, will serve as a valuable, freely available, resource for French researchers investigating gene function and human pathophysiology.

As expected, tissue studies of the δ - sarcoglycan knockout mice revealed a distinctively different pattern of muscle damage when compared to the damage the researchers found in knockout mice missing the α - sarcoglycan gene.

This visualization shows tightly - packed DNA in a mouse cell's nucleus at different stages of development, seen here in a semi-triangular form as a mature nerve cell; in a roundish shape as a multipotent stem cell; in a more oval form as a neuronal progenitor; and as a more fragmented structure that shows how removing a specialized binding protein (HP1β knockout) affects the structure of the DNA - packing material, called heterochromatin, in a mature neuron.

For example, mice rendered vitamin D deficient exhibit enhanced cancer development and cancer growth (34), as do vitamin D receptor knockout mice (35).

EMMA strains produced from ES cells generated by the International Knockout Mouse Consortium (IKMC) are displayed on the EMMA strain list as soon as germ - line transmission has been achieved and the genotype of the pups has been confirmed.

hESC lines I6 and H9 were maintained on Matrigel (BD Biosciences, Bedford, MA; http://www.bdbiosciences.com) coated dishes in medium (comprised of Dulbecco's Modified Eagle's Medium / Ham's F12 supplemented with 20 % knockout serum replacement (KSR), 2 mM non-essential amino acids, 4 mM L - glutamine, 0.1 mM β - mercaptoethanol, 50 µg / ml Penn - Strep, and 4 ng / ml of basic fibroblast growth factor) conditioned with mouse embryonic fibroblasts for 24 hours as previously described [9], [10].

The HZI will also provide access to laboratory and animal facilities up to BSL3 (including the gnotobiotic unit) and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

The results implicate GPC6 as a novel determinant of BMD, and also identify abnormal skeletal phenotypes in knockout mice associated with a further 100 prioritized genes.

However, recent evidence indicates that apoE4 expression compromises the blood - brain barrier (as does apoE deficiency).40 Studies of brain histology, neurodegenerative markers, cholinergic activity, and neuronal function in knockout mice have been equivocal.39 Failure of detailed neurocognitive and retinal studies to demonstrate defects in our patient suggests either that the functions of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate protein.

They used knockout mice — mice in which specific proteins were deleted from the genome — to classify vitamin K - dependent and selenium - dependent proteins as «essential» (if the knockout mouse died) or «nonessential» (if the knockout mouse was merely sickly).