Sentences with phrase «knockout mice did»

Both behavioral and physiological experiments revealed that the Ggamma13 knockout mice did not respond to odors.

Not exact matches

I hope wenger does not take it as MICKEY MOUSE CUP VERSION - 2 and keep playing the kids coz we may be really embarrassed in the knockout stages in europe, especially against the likes of the above mentioned teams and a.c.milan, lazio etc... who are in a descent form in this competition so far...

The knockout mice, which will be made available to academic researchers at low cost, should help efforts to figure out what newly discovered genes do in the body.

To find out what BRCA2 does normally, the team reporting the new results, which includes Allan Bradley of Baylor College of Medicine in Houston and Paul Hasty of Lexicon Genetics Inc. in The Woodlands, Texas, created «knockout» mice in which the gene was inactivated.

«The next thing to do is to generate a knockout mouse model for further in vivo analysis, as the ultimate goal of our research is to move from bench to bedside, and generating a mouse model is a key step during this long journey,» Shi said.

The team then administered progesterone inhibitors to normal mice and found that the animals behaved much as their knockout counterparts did.

The knockout mice also did better on tests of behaviors associated with the brain's prefrontal cortex, the area that regulates complex thinking, emotions, and behavior in humans.

When these knockout mice were fed a high - fat diet, they gained as much weight as normal mice did, but they managed to remain sensitive to insulin.

Normal mice produced more than four times more melanocytes than did the p53 «knockout» mice.

«This paper has little to do with knockout mice,» he continues.

Moreover, we found that T cells from double - knockout (DKO) mice did not demonstrate enhanced tumor activity above that observed in DGKζ single - knockout (KO) mice.

Cholesterol - induced hepatic inflammation does not underlie the predisposition to insulin resistance in dyslipidemic female LDL receptor knockout mice.

The huntingtin (htt) protein has been found to play an essential role during embryogenesis, since knockout Hdh mice do not survive gestation (Duyao et al., 1995; Nasir et al., 1995; Zeitlin et al., 1995).

For example, mice rendered vitamin D deficient exhibit enhanced cancer development and cancer growth (34), as do vitamin D receptor knockout mice (35).

Ellappan Babu, Yangzom Bhutia and Sabarish Ramachandran performed most of the experiments; Jaya Gnanaprakasam did the ELISA for cytokines; Puttur Prasad and Muthusamy Thangaraju were responsible for the design of the targeting vector used in the generation of the knockout mouse and also for the analysis of plasma amino acids; Vadivel Ganapathy was responsible for the design of the study, interpretation of the data, and writing of the manuscript.

Hypercholesterolemia - prone mice that were engrafted with bone marrow obtained from homozygous or heterozygous Tet2 knockout mice had larger atherosclerotic lesions in the aortic root and aorta than did mice that had received control bone marrow.

However, this significant reduction in adipose mass does not cause the overt metabolic dysfunction seen in Bscl2 knockout mice, even following a high - fat diet challenge.

However, recent evidence indicates that apoE4 expression compromises the blood - brain barrier (as does apoE deficiency).40 Studies of brain histology, neurodegenerative markers, cholinergic activity, and neuronal function in knockout mice have been equivocal.39 Failure of detailed neurocognitive and retinal studies to demonstrate defects in our patient suggests either that the functions of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate protein.