Sentences with phrase «knockout mice exhibit»

El - Khodor, B. F.; Dimmler, M. H.; Amara, D. A.; Hofer, M.; Hen, R.; Brunner, D. Juvenile 5HT (1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT (1A) receptor activation.

p11 knockout mice exhibit a depression - like phenotype and have reduced responsiveness to 5 - HT1B receptor agonists and reduced behavioral reactions to an antidepressant.

Not exact matches

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

In SIRT6 knockout mice, which exhibit accelerated aging phenotype, haploinsufficiency of p65 subunit of NF - kB resulted in improved lifespan 33.

Adrenal chromaffin cells exhibit impaired granule trafficking in NCAM knockout mice.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

For example, mice rendered vitamin D deficient exhibit enhanced cancer development and cancer growth (34), as do vitamin D receptor knockout mice (35).

MAOA knockout (KO) mice display elevated levels of DA, NE and 5 - HT and male KO mice exhibit increased aggressive behavior [8].