Sentences with phrase «knockout mice lacking»

In previous studies, Campbell's team had found that knockout mice lacking α - sarcoglycan had no heart muscle damage, even though their skeletal muscles showed the deterioration typical of MD..

Looking forward, the researchers plan to investigate knockout mice lacking the gene that produces AGF to further define its role.

We generated knockout mice lacking synaptobrevin / VAMP 2, the vesicular SNARE protein responsible for synaptic vesicle fusion in forebrain synapses, to make use of the exquisite temporal resolution of electrophysiology in measuring fusion.

In fact, 5 - HT2AR knockout mice lack drug - elicited HTR.

Not exact matches

Knockout mice, which completely lacked the gene and so manufactured no mu opiate receptors, were all the more sensitive.

Because mice lacking both genes would not be born alive, the scientists followed up this lead by making «conditional knockout mice,» in which Esrp1 and Esrp2 activity was normal early in fetal development, but then was switched off in skin epithelial cells.

Suspecting that a protein called Ggamma13 might be involved, the research team engineered mice to be lacking this protein and then tested how the «knockout» mice responded to odors.

In an attempt to increase sensitivity for sepsis, Canaan aged these FAT10 knockout mice and made the discovery that mice lacking the gene were lean and aged more slowly.

Zeroing in on this kinase was encouraging, Goga said, because other researchers have shown that genetic - knockout mice that lack the entire family of PIM kinases are slightly smaller than normal mice, but «basically fine,» indicating that a drug targeting just PIM1 may have manageable levels of toxicity in breast cancer patients.

As in earlier studies, the investigators, led by Ren Hen of Columbia University, first created a line of so - called knockout mice that lacked the gene encoding the receptor protein.

Campbell and his colleagues began their work by genetically engineering knockout mice that lacked a functioning protein called δ - sarcoglycan, which is part of a larger molecular assemblage called the dystrophin - glycoprotein complex (DGC).

(1) The authors mention in the Abstract that lack of neurodegeneration in DJ - 1 knockout mice is likely due to lack of mtDNA damage.

The researchers also found that knockout mice, which lack a functional DMRT3 gene, have an altered pattern of locomotion.