Sentences with phrase «knockout model»

Evidence from mouse knockout models and human mendelian disorders suggest that these transcription factors have a function in determining cell identify in the developing breast.

Construction of somatic cellular knockout models for the determination of protein functional impacts on various cellular processes:

For example, we often screen only 15 - 25 mice when generating knockout models with CRISPR and find that many, if not all, the mice carry a frameshift mutation.

However, the mouse genome is much easier to manipulate than that of the rat allowing for several knockout models, including the LDLr KO mouse, to show responses (i.e. hyper - TG) to high dietary fructose (8).

In a gastrin knockout model, achlorhydria is present because of the inactivation of enterochromaffinlike (ECL) cells and parietal cells.

In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology.

Secondly, they enable the use of animals with physiology more similar to humans rather than mice, which are the animal of choice for most mammalian gene knockout models.

Using this frataxin knock - in / knockout model, the researchers found significantly reduced levels of the mitochondrial biosynthesis master generator protein PGC - 1?

For their investigations, the team from the Children's Hospital of Philadelphia, Weill Cornell Medical College, Queen's University Belfast and the University of Pennsylvania used a frataxin knock - in / knockout model mouse model that has been available for a number of years, but had previously been overlooked for Friedreich's ataxia research as the neurological phenotype is modest and has a slow onset.

Continue to develop clinically relevant preclinical chemoprevention models through the prevention lab (e.g., tissue / organ gene knockout models)

Lexus looks like it has another knockout model to add to its growing F Sport lineup.