Sentences with phrase «knockout model mouse»

Not exact matches

Based primarily at Harvard with Maniatis, tenOever developed a knockout mouse model to study a particular protein, IKKε, that's involved in the immune response to viral infection.

«There have been many knockout mouse models of cleft palate, but very few of cleft lip, which is actually the more common defect in humans,» Carstens said.

He also hopes that the Esrp1 - knockout mice will prove to be a valuable new model for studying cleft lip.

«The next thing to do is to generate a knockout mouse model for further in vivo analysis, as the ultimate goal of our research is to move from bench to bedside, and generating a mouse model is a key step during this long journey,» Shi said.

In this study, by using a systemic mtEF4 gene knockout mouse model, researchers found that mtEF4 knockout damages the oxidative phosphorylation function in germ cells of male mice, thus causing male sterility.

In another experiment, the researchers tested whether MMP - 9 has a functional role in ALS by crossing MMP - 9 knockout mice with SOD1 mutant mice (a standard mouse model of ALS).

The modern mouse model is somewhat more precise, owing to knockout technology.

«Eliminating endothelial CD146 by conditional knockout in two different mouse models of colitis significantly reduced the severity of inflammation and decreased tumor incidence and tumor progression in a mouse model of CAC,» reports lead investigator Xiyun Yan, PhD, from the Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing.

«The one thing that I think that is useful is maybe when people write knockout papers they might describe the housing conditions in more detail,» says Chris Paszty, scientific director at the biotech company Amgen, Inc., headquartered in Thousand Oaks, Calif., who as a postdoctoral researcher at Lawrence Berkeley National Laboratory developed a mouse model for the study of sickle cell anemia.

Because the phenotypes were distinct in these knockout mouse models with respect to spontaneous cage activity and fast muscle isometric contractile characteristics, we can conclude that the roles of IL - 15Rα and IL - 15 in vivo are distinct with regard to muscle function.

To this aim we generated new conditional knockout mouse strains, which are currently analyzed to unravel the mechanism of a recently discovered unexpected protective role of TNFSF14 / LIGHT by our lab in an Inflammatory Bowel Disease (IBD)- like mouse model.

The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.

For example, we often screen only 15 - 25 mice when generating knockout models with CRISPR and find that many, if not all, the mice carry a frameshift mutation.

«NIH is committed to making knockout mouse models more widely accessible to the biomedical research community,» said James Battey, M.D., Ph.D., director of the National Institute on Deafness and Other Communication Disorders (NIDCD), who is also the co-chair of the Trans - NIH Mouse Initiamouse models more widely accessible to the biomedical research community,» said James Battey, M.D., Ph.D., director of the National Institute on Deafness and Other Communication Disorders (NIDCD), who is also the co-chair of the Trans - NIH Mouse InitiaMouse Initiative.

BETHESDA, Md., Wed., Oct. 5, 2005 - The National Institutes of Health (NIH) today announced contracts that will give researchers unprecedented access to two private collections of knockout mice, providing valuable models for the study of human disease and laying the groundwork for a public, genome - wide library of knockout mice.

Up to now, all models have been generated from ES mutant cells with conditional potential generated by the International Knockout Mouse Consortium (IKMC).

«Our decision to procure these knockout mouse lines and data and make them available to the research community will yield tremendous benefits, both in the short and long terms,» said NIH Director Elias A. Zerhouni, M.D. «This trans - NIH initiative will place important mouse models into the hands of researchers, speeding advances in the understanding of human disease and the development of new therapies.

Meehan et al., (2017) Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

In the study, «Multiple Risk Pathways for Schizophrenia Converge in Serine Racemase Knockout Mice, a Mouse Model of NMDA Receptor Hypofunction,» Dr. Coyle's group sought to determine whether this diverse pathology could be linked to NMDAR hypofunction, and thus used the SR - / - mouse mMouse Model of NMDA Receptor Hypofunction,» Dr. Coyle's group sought to determine whether this diverse pathology could be linked to NMDAR hypofunction, and thus used the SR - / - mouse mModel of NMDA Receptor Hypofunction,» Dr. Coyle's group sought to determine whether this diverse pathology could be linked to NMDAR hypofunction, and thus used the SR - / - mouse mmouse modelmodel.

With the help of conditional and function - selective knockout mice for the glucocorticoid receptor (GR) the lab identified critical cell types and novel mechanisms for anti-inflammatory activities of glucocorticoids in different inflammatory disease models.

the International Knockout Mouse Consortium (IMKC) which coordinates the activity of mutagenesis for the mouse Mouse Consortium (IMKC) which coordinates the activity of mutagenesis for the mouse mouse model

The findings also support using the Tff1 - knockout mouse model for in vivo studies of molecular mechanisms in gastric cancer.

Cutaneous SCC is a clinically aggressive cancer, and the inactivation of p21waf1 / cip1 has been shown to play a critical role in the formation of skin tumor in knockout mice models (14, 15).

Transgenic models session Chairs V.Korinek & Z. Kozmik 16.00 Bohumil Fafílek Cell tracking and manipulation in genetically modified mice 16.30 Michaela Krausová Mouse transgenic model to study tumor progression and metastasis in the gut 17.00 coffee break 17.20 Matej Durik Rodent transgenic models of cardiovascular diseases 17.50 Jan Masek The role of Wnt / beta - catenin signaling in neural crest development: an insight from transgenic and knockout mice 19.00 dinner

Soutto M, Schneider B, Piazuelo MB, Washington MK, Crowe S, Correa P, Peek RM, and El - Rifai W. Molecular signature of NF - kB signaling in the TFF1 - knockout mouse model of gastric neoplasia.

Evidence from mouse knockout models and human mendelian disorders suggest that these transcription factors have a function in determining cell identify in the developing breast.

Defining the range of pathogens susceptible to ifitm3 restriction using a knockout mouse model

Defining the range of pathogens susceptible to ifitm3 restriction using a knockout mouse model Everitt A. R., Clare S., McDonald J. U., Kane L., Harcourt K., Ahras M., Lall A., Hale C., Rodgers A., Young D. B., Haque A., Billker O., Tregoning J. S., Dougan G., Kellam P. Plos one, 2013 8 (11): e80723.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

WFSM establishes laboratory to develop transgenic and knockout mice to model human disease and shed light on function of human genes.

Awareness about 2 important publications from IMPC consortium 1 - The analysis of IMPC database that uncovers 360 new human disease models has just been published: Meehan et al., (2017) Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Reconstruction of transgenic and gene knockout and knockin mouse models of human diseases.

The Comparative Mouse Genomics Centers Consortium (CMGCC) was initiated by the National Institute of Environmental Health Sciences» (NIEHS) Environmental Genome Project to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive gMouse Genomics Centers Consortium (CMGCC) was initiated by the National Institute of Environmental Health Sciences» (NIEHS) Environmental Genome Project to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive gmouse models based on human DNA sequence variants in environmentally responsive genes.

96/3: 45 RNF12 is essential for X-inactivation in female mouse embryonic stem cells, is required for female mouse development, and might be a target for future therapies to treat X-linked disorders in females: Evidence from a mouse knockout model.

The HZI will also provide access to laboratory and animal facilities up to BSL3 (including the gnotobiotic unit) and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

The Mouse Core (G) targeted multiple associated genes to generate a collection of knockout and conditional knockout mutant models.

The team conducted a multi-disciplinary research composed of scientific techniques, computational modeling and having knockout mice as the subject to see the concealed mechanism of sleep.

However, the mouse genome is much easier to manipulate than that of the rat allowing for several knockout models, including the LDLr KO mouse, to show responses (i.e. hyper - TG) to high dietary fructose (8).

Gastric knockout mouse models with inactivated parietal cells subsequently develop achlorhydria.

The lipocalin - type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic - pituitary - adrenal axis hyperactivity