Sentences with phrase «knockout technology»

Within a year's time, two back - to - back papers documented the application of CRISPR - Cas9 knockout technology to forward genetic screening5, 6.

Under the grant, Lexicon will utilize its proprietary gene knockout technology to identify genes that, when knocked out, lead to increased levels of mouse Smn protein.

«Under this grant, we will utilize Lexicon's proprietary gene knockout technology to study genes that may impact the function of motor neurons to advance treatments for spinal muscular atrophy,» said Brian P. Zambrowicz, Ph.D., executive vice president of research at Lexicon.

The modern mouse model is somewhat more precise, owing to knockout technology.

Not exact matches

Derived mostly from human embryonic kidney 293T (HEK293T) and HeLa cell lines, EdiGene Knockout (KO) Cell Lysates have been optimized through the use of genome editing technology and validated at the genomic level through PCR and Sanger - sequencing techniques to ensure the accuracy and knockout of the targKnockout (KO) Cell Lysates have been optimized through the use of genome editing technology and validated at the genomic level through PCR and Sanger - sequencing techniques to ensure the accuracy and knockout of the targknockout of the target gene.

This achievement is expected to become a very useful technology for future mass production of knockout mice.

Transgenic and gene knockout / knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.

These knockout cell lines allow researchers to quickly validate their gene or target of interest, without having to invest time and resource in developing in - house CRISPR technology.

Using CRISPR / Cas9 technology, we generated biallelic knockout mutations in host genes encoding IRF5 and IL - 10RA in iPSCs, and confirmed their roles in limiting chlamydial infection in macrophages.

Participants will learn design of CRISPR targets using bioinformatics tools, generation of gene knockouts / knock - ins, and target validation using the most current technologies.

KNOCKOUT Yoga instructor Lindsey Valdez leads a Sound Off Submerge experience curated with deep house beats using Sound Off headphone technology.

Cadillac surprised the world with its beautiful ELR plug - in hybrid coupe, featuring knockout styling that turns heads and novel technology that opens wallets — but then it surprised the world again by pricing it out of consideration for anyone who'd likely buy one.

Summary * Designed and produced 32 knockout mutants using CRIPSR / Cas9 technology.

Extensive exposure in end - to - end development of software products * Strong experience in web technologies such as HTML / HTML5, CSS / CSS3, JavaScript, jQuery, AJAX, Angular JS, Bootstrap, Knockout JS, Node JS, Angular 2/4.