Sentences with phrase «know the genes responsible»

Just because scientists know the gene responsible for a rare disease doesn't mean they know what's going on.

Not exact matches

«We want to know which are the most important genes that are responsible for the improved learning and recovery of memories,» she adds.

With the aid of DNA markers, we now know which gene is responsible for which molecular feature.

The researchers discovered the actions of multiple independent meiotic drivers in fission yeasts in an earlier study, reported in 2014 in eLife, but didn't know which genes were responsible, or how they destroyed gametes that didn't inherit the genes.

Researchers have known for decades that the glycophorin cluster of genes is highly variable, but it was not possible to show that this genetic variation was responsible for protecting people against severe malaria.

In most cases, the genes responsible for these processes are known as «transcription factors» — meaning that they are responsible for turning other genes on and off.

But for a gene therapy to be effective, one must know the precise gene responsible for a given individual's disorder and develop a tailored treatment.

The team attempted to modify the gene responsible for β - thalassaemia, a potentially fatal blood disorder, using a gene - editing technique known as CRISPR / Cas9.

If we know which genes are responsible for breast cancer, then we can tailor therapies to target those genes specifically.»

If researchers could identify and screen for the responsible genes, such people would know that solitude could leave them vulnerable.

In 1991, Robertson and her colleagues reported an unusual discovery involving a gene called Igf2, which is responsible for producing a protein known as insulin - like growth factor II (IGF - 2), important for the growth of many kinds of tissue in the developing fetus.

As it is well known that hypertension is a complex, multifactorial, quantitative trait under a polygenic control, 30 % to 50 % of the variation in blood pressure between individuals is attributed to genetic factors, and the genes responsible for susceptibility and blood pressure variation are mostly unknown.

«There are some patients with retinal disease who don't show gene mutations that we know are responsible for disease,» he said.

Dr Jamshidi said: «These findings can be used for diagnostic testing of people with symptoms similar to those described in this study and where the gene responsible for their condition is not known.

The first known identification of two genes responsible for hypoplastic left heart syndrome (HLHS), a severe congenital heart defect, has been reported by researchers at the University of Pittsburgh School of Medicine.

For more than two decades we've known that a single gene on the Y chromosome, called Sry, is responsible for male sex determination.

Engelhardt's group was responsible for mapping associations between genetic variants and gene expression levels on different chromosomes, a connection known as «trans - expression quantitative trait loci (trans - eQTLS).»

If we know which organs or tissues are most responsible for transporting copper throughout the body, we can focus on making sure the gene is expressed in those areas.

In another paper in the same issue, a team led by molecular biologist Ronald Plasterk, now at the Hubrecht Laboratory in Utrecht, the Netherlands, reports an intriguing twist: The same genes appear to be responsible for both RNAi and another gene - silencing mechanism known as cosuppression, in which adding extra copies of a gene cause both the new and the existing copies of that gene to be shut down.

However, while the genetic factors responsible for reprogramming are well known, the mechanisms underlying the responses to induced gene expression changes are not as clear.

Until now, we didn't know any of the phytoplankton genes responsible for the synthesis of this highly abundant marine nutrient.»

«We suggest to sequence the healthy DNA and that of the tumor of each patient to really know which genes are responsible for the development of cancer,» explains Nikolaev.

For example, we know that certain genes are responsible for autism and can use our model to give us insight into at what point the disorder begins developing.»

Previously known mutations in the gene encoding SLC25A3 are responsible for poorly understood genetic disorders involving dysfunctional heart and muscle fibers, leading to enlarged hearts and low muscle tone.

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

Finding the genes responsible for the increased risk is not straightforward because small sequences of DNA can interact with completely different parts of the genome through a strange phenomenon known as «DNA looping».

PPARγ was initially linked to adipocyte (fat cell) differentiation, but we now know that it also regulates genes responsible for lipid uptake, accumulation, and storage of lipids in those cells.

Best known for identifying and cloning the desaturase gene in Arabidopsis, which is responsible for the synthesis of polyunsaturated fatty acids in plants, Browse has since been a leader in the effort to bioengineer crop plants to produce oils with increased levels of heart - healthy monounsaturated fatty acids.

Tet2 is a type of cellular enzyme known as an epigenetic regulator — responsible for making specific chemical annotations to regions of DNA that alter the activity of many different genes.

In the new study, published online March 27, 2018, in Cell Reports, a team led by UCSF's David Raleigh, MD, PhD, found that increased activity of a gene known as FOXM1 appears to be responsible for the aggressive growth and frequent recurrence of these tumors.

Colleagues describe John Browse as simply one of the top plant biologists in the world.Best known for identifying and cloning the desaturase gene in Arabidopsis, which is responsible for the synthesis of polyunsaturated fatty acids in plants, Browse has since been a leader in the effort to bioengineer crop plants to produce oils with increased levels of heart - healthy monounsaturated fatty acids.

The results suggested that each of the Wnt genes (Wnt - 2b, Wnt - 8c, Wnt - 3a) were responsible for turning on two forms of FGF, each of which controls both limb initiation and a bud or bulge known as the apical ectodermal ridge (AER), which acts as the «organizer» of limb development.

With his bioengineering experience, Denby knew that it was possible, though difficult, to isolate the genes that code for those two flavor molecules and insert them into brewer's yeast, the microbe responsible for fermenting barley into beer.

-- We have shown that the genetic change causing fibromelanosis is a complex rearrangement that leads to increased expression of Endothelin 3, a gene which is known for promoting the growth of pigment cells, explains Ben Dorshorst the post-doctoral researcher responsible for the work.

Using genetic maps, scientists know that the mutated gene responsible for this tolerance lies on chromosome 1, now they just need to find it.

The drug, named Inclisiran, utilizes a technique called RNA interference therapy which targets, and switches off, a specific gene known to be responsible for elevated LDL levels.

Of course, we know that genes alone are not responsible for cancer because we share many of the same genes as our hunter — gatherer ancestors and even just the same genes as our ancestors several generations ago, and yet the rate of cancer keeps going up.

It is very likely that you have a genetic variant on a gene known as the MTHFR gene which is responsible in part for a very common and necessary chemical reaction known as methylation.

White Miniature Schnauzers do not possess the «d» allele, which is commonly known as the Dilution gene responsible for diluting both eumelanin and phaeomelanin pigment.

Thanks to some feral cats in Northern California, scientists now know that the same gene responsible...

Thanks to some feral cats in Northern California, scientists now know that the same gene responsible for giving tabby cats their wide array of bands and blotches is also responsible for a zebra's stripes and a cheetah's spots.

Since the proteins that form the viral spikes (corona) are known to be responsible for docking and entry, scientists are concentrating on that area looking for the specific things (S genes) that may have changed there.

However, responsible breeders will more than likely have vets doing gene testing for them to weed out known genetic diseases of the crossbreeds.

The same study found that in Shetland Sheepdogs a mutation of the pigmentation gene known as Silver (or Silv) is probably responsible for the merle pattern.