Sentences with phrase «know the mechanism involved»

But like other researchers, they didn't know the mechanism involved.

Not exact matches

The concept known as Proof of Work (PoW) serves as a consensus building mechanism to reward legitimate participants and prevent malicious hackers from taking over the network.18 However, most of the calculations involve trying out nonce (random numbers that can only be used once) to satisfy a desired output format.

Unfortunately, our descent was interrupted unexpectedly by — and the party involved shall remain nameless for perpetuity, though by now everyone we know knows all — the wedging of a Croc, which this party was wearing, into the mechanism of the escalator about two - thirds of the way down.

«All these mechanisms seem to work, but we still didn't know which is the dominant source of lunar water,» says NASA scientist Alan Stern, who was not involved in the new work.

Seeking additional insight into similar mechanisms at work in other centers of the brain, Donato and his team discovered that the signal to develop one area known to be involved in more abstract functions, including memory and navigation, originated from deep within the brain, in a specific population of neurons that kicks off the maturation of an entire neural network.

Biologists have long known that the mechanism involved two drops of water interacting with the half - egg shape of spores launched in this way: an elongated drop that forms on its flat side, and a small spherical drop called a Buller's drop that sits near the rounded base of the spore.

«You need to know the ingredients required and the mechanisms involved in the transport of calcium.

But they think that by looking at some of the chemical basis of, you know, weight loss and / or weight gain, then by manipulating it — and they also look for the genes involved in these chemical signals — then they can possibly translate that into drugs for humans or just understanding better the mechanism of weight loss and weight gain.

And we now know that it is the same epigenetic mechanisms that occur in brain as occur in liver, just involving, only the specifics differ — brain genes in brain, liver genes in liver.

Researchers at Aarhus University, Denmark, have succeeded in identifying the mechanisms involved in what is known as the acid pump, which at the cellular level pumps acid into the stomach — in some cases leading to gastric ulcers and gastroesophageal reflux disease.

And researchers are unsure of the mechanisms involved and do not know if their preliminary results would transfer to humans in real - life scenarios.

Calbindin also has been known for a long time to be involved in Alzheimer's disease and epilepsy, but its mechanism of regulation was not known.

«The biochemical mechanisms of these proteins have been known for years from experiments involving purified protein and DNA, and that's very important, but in this new work we've clarified these proteins» roles in living cells,» said co-senior author Christopher P. Selby, PhD, research assistant professor of biochemistry and biophysics at UNC.

One regulatory mechanism known to be involved in skin development and renewal is chromatin modification.

Right now, its causes are unknown although various self - immune mechanisms are known to be involved.

University of Alabama at Birmingham researchers show, for the first time, that the well - known mechanism of gene expression control — dynamic changes in DNA methylation — is also involved in changes to the excitability of neural cells.

Washington knew that the mechanisms involved in vision tend to be similar throughout the animal kingdom, so he wondered whether chlorophyll could also enhance the vision of other animals, including humans.

Most analytical approaches to this problem are rather rudimentary and involve calculating simple correlations among the genes whose expression changes in response to a perturbation, clustering the genes by molecular or known functional class, and drawing crude inferences about mechanism on that basis.

For the first time, through the use of human embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm's Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrophy.

The mechanism involved is up for debate, but the known role of B2M relates to the adaptive immune system.

The underlying mechanism for this tolerizing phenomenon, including the involved target cells, is not yet known.

Miller said that other proteins anchored to the cell surface in a similar fashion are known to play roles in cell proliferation, suggesting a possible mechanism for how HYAL2 might be involved in tumor formation.

«We know relatively little about the behavioral or ecological mechanisms that allow these induced defenses to be effective,» says Richard Karban, an ecologist at the University of California, Davis, who was not involved in the work.

The researchers used a technique called RNA interference (RNAi) to screen a group of genes known to be involved in animal development, in order to study the signaling mechanisms that regulate whether the animal would produce a head or tail during regeneration.

Well, we really don't know at this time, but based on some of the studies done, it appears that both can occur simultaneously, but depending on the mechanism leading to metabolic disease it can involve one or both pathways.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Based on laboratory experiments aimed at determining the molecular mechanisms involved, scientists knew that pink bollworm could evolve resistance against the Bt toxin, but they had to go all the way to India to observe this happening in the field.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Uterine leiomyomas, also called fibroids, cause a very significant burden to women's health but relatively little has been known about the mechanisms of tumorigenesis involved.

One mechanism could be to differentially regulate the molecular components involved in cue detection, such as ORs or VRs [20] or in known elements of their signal transduction pathways, under the control of sex - specific hormones.

However, we do not know how widely the mechanisms involved in the regulation of transposons are used throughout the rest of the genome.

«And if we know exactly which cell types and which mechanisms are involved, we can potentially develop specific medicines to treat it.»

Actually, we know one of the mechanisms whereby colon cancer is initiated, and it does not involve meat per se.

«When something hurts, we look for ways of relief, but the mechanisms that we know of relief, unfortunately, oftentimes involve food addictions or other addictions.

This makes sense to everyone on a visceral level, but do you know the physiological mechanisms involved?

Eventually, when we know more about the effects of the mechanisms involved, fluctuations in cosmic rays could be incorporated in helping model cloud albedo changes.

Please be precise about the mechanisms, volumes and timescales, just saying ocean circulations is not good enough, given what we know about the very long timescales involved to move the water.

I think it is fair to say that we do not know all the mechanisms involved between the sun and our climate (for example, things like the GCR cloud hypothesis being tested at CERN), and IPCC has conceded that its «level of scientific understanding of solar (natural) forcing is low».

Well — no it doesn't — it won't — and while is some very basic radiative physics involved — the fundamental mechanism of climate is chaos.

It is not clear to me, what well known physics is involved in that frequency stuff, but I think if the geometric pattern is fixed to the frequencies in the solar heat system it could be taken as a climate guide for the next millennium, also as long the physical mechanism is not understood.

Everything else you are referring to has either no known physical mechanism underling it or involves a known but very very small effect (e.g..

The plan was to save their forest and earn offsets for the carbon captured in trees under a financing mechanism know as REDD (Reducing Emissions from Deforestation and Degradation), but REDD project standards require a «Free Prior and Informed Consent» (FPIC, pronounced «F - pic») by the local people, a measure that requires disclosure, discussion and agreement — a process involving far more than just a few meetings between community leaders and a project developer.

Membership in a single - parent family or stepfamily is associated with increased levels of significant behavioral, emotional, and academic problems in children.1, 2 The mechanisms underlying this connection are likely to involve, among other factors, financial adversity, increased stress directly related to family transitions, and increased exposure to additional psychosocial risks.3, 4 Compared with the extensive research base connecting family type (ie, membership in a 2 - parent biological family, stepfamily, or single - parent family) and children's psychological adjustment, little is known about the physical health consequences of membership in diverse family types.