Sentences with phrase «known as amyloid»

In what reviewers described as a «technological tour de force,» John R. Cirrito and David M. Holtzman of the Washington University School of Medicine in St. Louis traced production of a destructive Alzheimer's protein, known as amyloid - beta (right), to the junctions between neurons called synapses.

A definitive diagnosis of Alzheimer's includes dementia and two distortions in the brain: amyloid plaques, sticky accumulations of misfolded pieces of protein known as amyloid beta peptides; and neurofibrillary tangles, formed when proteins called tau clump into long filaments that twist around each other like ribbons.

More than 40 illnesses known as amyloid diseases — Alzheimer's, Parkinson's and rheumatoid arthritis are a few — are linked to the buildup of proteins after they have transformed from their normally folded, biologically active forms to abnormally folded, grouped deposits called fibrils or plaques.

In the current study, a collaborative team of researchers at the Gladstone Institute and the Baylor College of Medicine in Houston, created a strain of mice that overproduces a precursor of Aβ known as amyloid precursor protein.

Smith says her group is investigating whether PET imaging of serotonin could be a marker to detect progression of disease, whether alone or in conjunction with scans that detect the clumping protein known as amyloid that accumulates in the brains of those with Alzheimer's disease.

As these misfolded proteins aggregate together, they create long fibrous structures known as amyloids.

Sup35 is a prion — a type of protein that can form tangled clumps known as amyloids.

Not exact matches

Most recently, he noted, researchers reported in Science that sleep functions as a kind of «sewer system» for the brain, at least in mice, by flushing beta - amyloid, which is known to accumulate in the brains of patients with Alzheimer's disease.

Whereas analyses of the brain were once limited to autopsy samples at the time of a person's death, advances in an imaging technique known as positron emission tomography (PET) now enable researchers to detect amyloid and tau in the brains of living people.

Known as a triple transgenic model, the animals develop three key characteristics of the disease: memory impairment, amyloid plagues, and neurofibrillary tangles.

In the second technique, physicians insert a syringe into the spinal column, withdraw cerebrospinal fluid, and analyze it for the presence of amyloid and another disease - related protein known as tau.

While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.

To better understand the presence and importance of these proteins in the urine of pregnant women with preeclampsia, the team used a dye called Congo Red, which was known to bind proteins such as amyloid based on previous research done with other protein misfolding conditions.

In the past decade or so, evidence has been mounting for a controversial theory that rogue proteins, known collectively as amyloids and associated with diverse neurodegenerative diseases — from Alzheimer's to Parkinson's and Huntington's — might share some properties of prions, including their transmissibility.

Diamond and his colleagues have shown that a part of nerve cells» inner structure known as tau protein can misfold into a configuration called an amyloid.

In their lab, the researchers incubated certain amyloid beta fragments — referred to as Aβ (25 - 35)-- with cells (known as SH - SY5Y) often used in Parkinson's research.

Immunotherapy is a promising strategy for the treatment of Alzheimer's that uses antibodies to stimulate the immune system to remove pieces of a protein called amyloid beta which accumulates in the brain (in deposits known as plaques) and is thought to be a major factor driving Alzheimer's neurodegenerative effects.

The new study from a team at the Cleveland Clinic Lerner Research Institute focused on an enzyme called BACE1 (aka beta - secretase), which is known to contribute to the formation of the toxic amyloid proteins that congregate as plaques on the brain, and are hypothesized to be the source of most Alzheimer's symptoms.

The plaques are found between the dying brain cells, and they are made from a protein known as beta - amyloid.

Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt - Jacob disease — the human analog of mad cow disease.

CAMBRIDGE, Mass. (June 8, 2005)-- Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt - Jacob disease — the human analog of mad cow disease.

Other theories and lines of research have begun to prosper due to the lack of tangible human results for anti-amyloid immunotherapies, in particular that neurofibrillary tangles of misfolded tau protein are just as much a target for clearance as is amyloid - β, and that perhaps it is time to focus on the decline of known clearance mechanisms rather than the amyloid itself.

Verubecestat targets β - site amyloid - cleaving enzyme 1, also known as BACE1 or β - secretase.

They then added either an active type of the omega - 3 fatty acid DHA known as resolvin D1 or an active type of vitamin D3 known as 1alpha,25 - dihydroxyvitamin D3 to a few of the cells to evaluate the effect that they had on amyloid - beta absorption and inflammation.

A protein known as beta - amyloid and hydrogen peroxide are two compounds that play an important role in the development of Alzheimer's.

Electrical pulse patterns in the form of high - frequency bursts, known as spikes, and the synapses» filtering properties are critical to the ratio of amyloid - beta 40/42 regulation.

The spiking pattern and the kind of amyloid - beta produced association could revolve around a protein known as presenilin.

Scientists have identified a basic pathologic process underlying Alzheimer's development that involves the formation of abnormal protein deposits in the brain known as beta - amyloid plaques, but they still aren't entirely sure what causes this to happen.