Sentences with phrase «known as oncogenes»

In humans, cancer develops when genes that suppress cancer, known as tumor suppressors, are lost and when mutations or genes that promote cancer, known as oncogenes, are gained or activated.

Not exact matches

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

In 1984, while Duesberg was researching cellular and viral oncogenes, he heard Margaret Heckler, who was Secretary of Health and Human Services, announce that his then friend Robert Gallo had discovered that HIV was the cause of the mysterious new plague known as AIDS.

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.

A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene — a gene that promotes the development of cancer — and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival.

The B - raf gene belongs to a class of genes known as «oncogenes,» which send signals to normal cells that cause them become cancerous.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and division.

He served as a member of the graduate faculty in the Department of Molecular Biology at Princeton University and spent 10 years at NIH where he madesignificant contributions to the discovery of a class of proteins known as tyrosine kinase oncogenes as key regulators of the immune system.

Similarly, microarray analyses comparing global gene expression in cells that overexpress wild - type STAT3 or phosphorylation - deficient mutant indicate that a subset of genes are regulated by unphosphorylated STAT3, including well - known oncogenes such as MRAS and MET (Yang et al., 2005).