Sentences with phrase «known as tumor»

Cancer shortens the lives of nearly half of all dogs and cats in the U.S. Cancer in pets occurs when the body's immune system can not stop cells from replicating at an abnormally fast, disorderly pace and forming a mass known as a tumor.

The research, which was funded by the Food and Drug Administration and other federal health agencies, contradicts numerous earlier studies that did find an increased risk of infection associated with the drugs, known as tumor necrosis factor (TNF) inhibitors.

BRCA genes belong to a class known as tumor suppressors, according to the National Cancer Institute (NCI).

His efforts have pioneered the use of the three - dimensional «artificial skin» cultures to study the behavior of both tumor and normal cells that sustain tumor growth, a system known as the tumor microenvironment.

One of those signals is a substance known as tumor necrosis factor, or TNF.

In cancer research, the CBP and p300 proteins were known as tumor suppressors until the Panne lab showed that several known cancer mutations could cause p300 to over-activate itself.

Known as tumor - initiating cells with stem like properties these cells have many characteristics in common with normal stem cells in that they are self - replicating and capable of giving rise to populations of differentiated cells.

Matunis says the research may be useful for understanding cancer, because a lot of cancer involves cancer stem cells, also known as tumor - initiating cells.

In humans, cancer develops when genes that suppress cancer, known as tumor suppressors, are lost and when mutations or genes that promote cancer, known as oncogenes, are gained or activated.

After the KRAS mutation was induced by the researchers, other mutations in what are known as tumor suppressor genes developed.

But it's much harder to develop therapies that restore malfunctioning genes that should be triggering cell death in abnormal cells, known as tumor - suppressor genes.

Specifically A20 appears to call off a substance known as tumor necrosis factor (TNF).

Not exact matches

The key to this effort is the ability to detect what's known as circulating tumor DNA, or CTDNA.

It's as if the Earth now has two moons instead of one and both are growing in size like a cancerous tumor that may threaten the financial tides, oceans and economic life as we have known it for the past half century.

The pituitary tumor known as a prolactinoma is usually benign, and it might not require treatment.

Fibroids are also known as fibroid tumors, leiomyomas, or myomas.

When you are pregnant, you might experience growths on your gums that have a raspberry - like appearance known as «pregnancy tumors.»

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, and is known as Stk11, additionally influenced the development of BPH.

«We know that 70 - 75 percent of glioblastoma patients undergo surgery for tumor debulking, and we have previously shown that MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking,» he continued.

DIPGs are known as one of the most challenging tumors to treat because cancer cells are intimately intermingled with normal brain cells in a part of the brain that can not be surgically resected.

The ability for cancer cells to develop resistance to chemotherapy drugs — known as multi-drug resistance — remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to «turn off» their resistance capabilities.

To migrate from a primary tumor, a cancer cell must first break through surrounding connective tissue known as the extracellular matrix (ECM).

Excess expression of the sugar is caused by the same mutation that drives the growth of most DIPG tumors, known as the H3K27M mutation, the team found.

Tumors that originate in other organs of the body and spread to the brain are known as metastatic brain tTumors that originate in other organs of the body and spread to the brain are known as metastatic brain tumorstumors.

Differences in these processes and their effects on the stomach could help explain why H. pylori is more commonly associated with a cancer type known as gastric adenocarcinoma, while autoimmune disease is linked with neuroendocrine tumors.

As not all cases of Barrett esophagus become malignant, it is important for the treating physician to know whether there are reliable indicators (so - called biomarkers) which allow the estimation of a tumor development in the still benign tissue.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

Women with the KRAS - variant are also more susceptible to triple - negative breast cancer, tumors whose growth is not fueled by the hormones estrogen and progesterone, or by the presence of a particular genetic mutation known as HER2, which promotes cancer cell growth.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

One promising idea, known as magnetic hyperthermia, involves injecting minuscule «nanoparticles,» basically microscopic lumps of iron oxide or other compounds, into tumors to make them magnetic.

These benign tumors, known as enchondromas, are associated with severe pain, fractures, and skeletal deformities.

Although BRCA1's role in tumor initiation is well known, the fact that it also seems to be involved in tumor progression comes as a surprise, says Eliot Rosen, a molecular biologist at Georgetown University in Washington, D.C.

Apart from patient testimonials and a few preliminary studies in tumor cell lines and in mice, critics say, there is no evidence of the safety or efficacy of the compound, popularly known as the «cancer pill» or «fosfo.»

They found that NF - κB, a protein complex known to promote tumor growth, may also have the ability to boost the immune system to eliminate cancerous cells before they harm, as well as promote antitumor responses.

The class of medications that he conceived, known as immune checkpoint inhibitors, works counterintuitively: By turning off one of the immune system's built - in safeguards, the inhibitors allow T cells — the system's foot soldiers — to attack tumors more effectively.

However, several clinical trials are currently underway to assess a type of therapy that inhibits a DNA repair enzyme known as PARP in tumors with HRD,» said Heeke.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

People who have heart valve or blood infections of S. gallolyticus (previously known as S. bovis) often also have colorectal tumors.

Trebananib (formally known as AMG 386; Amgen) is a first - in - class peptide - Fc fusion protein (or peptibody) that targets angiogenesis (the growth of new blood vessels into cancerous tumors) by inhibiting the binding of both angiopoietin 1 and 2 to the Tie2 receptor.

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.

However, a majority of patients with advanced NSCLC worldwide do not have tumors with these mutations (known as wild - type [WT]; no mutation detected within the gene).

BRCA1 and 2, genes whose proteins are supposed to work as tumor suppressors and also repair DNA damage, were the first known risk factor genes for familial breast cancer as well as ovarian and other cancers.

«Currently, approximately 1 in 5 women who undergo breast - conserving surgery, also known as lumpectomy, require repeat surgery due to inadequate excision of the tumor during the initial surgical procedure,» explains Arnie D. Purushotham, MD, professor at King's College London, UK.

«Also, because Notch is known to be a tumor suppressor, the essential role of Rumi in Notch activation suggests that Rumi could be a tumor - suppressor as well.

One enzyme it does block, known as c - kit, causes gastrointestinal stromal tumors.

The primary endpoint of this trial is recurrence of breast cancer in the same breast, known as ipsilateral breast tumor recurrence (IBTR).

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

Although other tumor suppressors exist, what makes Par - 4 so special is that it is not mutated as frequently as other known suppressors, and it's «selective» in its actions in that Par - 4 will only kill cancer cells and not normal cells.

Researchers are investigating whether an injectable known as PV - 10 can shrink tumors and reduce the spread of cancer.