Sentences with phrase «known cancer driver»

«Blocking known cancer driver unexpectedly reveals a new tumor - promoting pathway: Targeting both pathways with drug inhibitors more effective in stopping colorectal cancer growth.»

«The major known cancer driver genes are often mutated in the primary tumor and all metastases, and successfully targeting them in therapy could provide widespread therapeutic benefit,» said Townsend.

Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78 % showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes.

Not exact matches

Activation of the PI3K / AKT signal pathway is a known driver of the progression of prostate cancer to the castrate - resistant stage, the most lethal form of prostate cancer.

Next, iCAGES cross-references these variants to databases of known cancer - causing genes, using statistical analyses and machine learning techniques to prioritize the most likely driver genes.

This rise in estrogen later in life is one of the known drivers of prostate cancer.

The gene HER2 is closely related to known lung cancer driver EGFR.

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances.

However, PI 3 - kinase activity, a well - known driver of prostate cancer, was notably absent from the metastasized tumors.

«More and more we're showing that cancers caused by ROS1 or many other genetic drivers may be treated with similar drugs no matter where the cancer lives in the body.»

(ref) High levels of GH stimulate cells to divide more frequently and more frequent cell division (mitogenesis) is a known driver of cancer.