Sentences with phrase «known cancer pathways»

Two clusters were associated with known cancer pathways — SHH signaling and WNT activation.

Just as the so - called AIDS «cocktail» directs multiple agents against multiple targets, so too might future anti-cancer cocktails be directed at multiple, highly specific targets in known cancer pathways.

Not exact matches

When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.

The Wnt pathway is known to be inappropriately activated in many major tumor types, including colon, breast, liver, lung and pancreatic cancers, and is critical for the function of CSCs.

Activation of the PI3K / AKT signal pathway is a known driver of the progression of prostate cancer to the castrate - resistant stage, the most lethal form of prostate cancer.

In testing multiple HDAC inhibitors in combination with the chemotherapy drug paclitaxel, known to give some benefit for this aggressive cancer, they found that class II HDAC inhibitors signal through a newly discovered pathway to promote synergy with chemotherapy treatment.

«We also know that this RhoB pathway, once turned on, can stimulate the expression of two proteins: p21, which prevents cells from replicating, and BIM, which induces cell death — both of which can help stop cancer growth.»

The publication, «Androgens Regulate Prostate Cancer Cell Growth via an AMPK - PGC - 1α - Mediated Metabolic Switch,» featured online in Oncogene, illuminates a known metabolic pathway as a potential novel therapeutic target.

Scientists now know that what matters most in determining the behavior of a particular cancer (and its response to specific therapy) are the molecular pathways that drive malignant cell growth instead of where the tumor begins in the body.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die.

But BRCA is just one of the many genes that encode important proteins in the DNA repair pathway known as homologous recombination,» says the study's lead author, Arielle Heeke, MD, a clinical fellow at Georgetown Lombardi Comprehensive Cancer Center.

But the researchers discovered that when the bacteria glom onto responsive colon cancer cells, the microbes boost a signal sent through a relay chain known as the beta - catenin pathway.

Their findings may turn out to be important when it comes to research into cerebral cancer, since it is known that components of the Hippo signaling pathway, such as neurofibromin 2, are involved in the generation of brain tumors.

«We have known for a long time known that there are important links between inflammation and cancer, including similar pathways that regulate normal and cancer stem cells,» says study author Max S. Wicha, M.D., distinguished professor of oncology and director of the U-M Comprehensive Cancer Ccancer, including similar pathways that regulate normal and cancer stem cells,» says study author Max S. Wicha, M.D., distinguished professor of oncology and director of the U-M Comprehensive Cancer Ccancer stem cells,» says study author Max S. Wicha, M.D., distinguished professor of oncology and director of the U-M Comprehensive Cancer CCancer Center.

«Blocking known cancer driver unexpectedly reveals a new tumor - promoting pathway: Targeting both pathways with drug inhibitors more effective in stopping colorectal cancer growth.»

Loss of the PBRM1 gene function caused the cancer cells to have increased expression of other genes, including gene pathway known as IL6 / JAK - STAT 3, which are involved in immune system stimulation.

The development of specific inhibitors that target the ERAD pathway could provide useful alternatives to some of the known proteasome inhibitors that stop the growth of cancer cells.

Poznansky's team — with lead scientist Huabiao Chen, PhD, corresponding author of the current report — had been investigating applications of AMD3100, a drug that blocks the CXCR4 / CXCR12 signaling pathway known to be involved in cancer development and in the way in which mesothelioma evades the immune system.

The pathway Kean and her team studied is Aurora Kinase A, a well - known genetic target for cancer researchers.

The findings, published in the Jan. 1, 2016 online issue of Cancer Research, demonstrated dietary sugar's effect on an enzymatic signaling pathway known as 12 - LOX (12 - lipoxygenase).

The discovery of the STAT pathway was cited as one of the 10 major breakthroughs of the year by Science, and the STAT pathway is known now as a major pathway involved in immunity control, development, and cancer pathogenesis.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

The «hotspots» of these trans associations, when grouped by pathway, highlight known targets of dysregulation in breast cancer such as ERBB2 and MYC.

Around 60 % of human colorectal cancers have mutations in the KRAS, BRAF or ERBB genes — all of which encode proteins coupled to the Ras pathway, a well - known way of transmitting signals within cells.

It is known that many drugs used in the treatment of various types of cancer including melanoma are targeting Met and hepatocyte growth factor (HGF)(or scatter factor (SF) pathways.

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

Whitehead Institute scientists report that the gene mutated in the rare hereditary disorder known as Birt - Hogg - Dubé cancer syndrome prevents activation of mTORC1, a critical nutrient - sensing and growth - regulating cellular pathway.

In response to this challenge, Addgene has launched an initiative to curate our collection of cancer - related plasmids such that each is linked to a known major pathway.

The more that is known about defects in specific pathways in specific cancer types, the more specific molecular targets — pathway components — appear in the sights of researchers trying to disable or enhance a given pathway.

While the promoter mutations were not near known pancreatic cancer genes, the team discovered that they affected some of the same biological pathways inside cells.

In studies using human cancer cell lines, a new, never - described compound known as BMH - 21 destroyed this critical communication pathway.

Researchers from the Broad Institute and elsewhere have identified novel mutations in a well - known cancer - causing pathway in lung adenocarcinoma, the most common subtype of lung cancer.

The other four genes (KNDC1, GPR123, EBI2, and GRINL1B) are not known to contribute to cancer pathogenesis, but they have potential roles in metabolic pathways that may act to promote cancer growth.

Mutations in one of these genes, NF1 — a known tumor suppressor gene that regulates the RTK / RAS / RAF pathway — had previously been reported in lung cancer.

May 11, 2015 Disrupting cancer pathway could enhance new immunotherapies Understanding how to overrule a signaling pathway that can cause treatments to fail in metastatic melanoma patients should help physicians extend the benefits of recently approved immunity - boosting drugs known as checkpoint inhibitors to more patients.

Drugging the autophagy pathway to combat cancer has been tried before, but the only drugs that currently block cell recycling work by targeting the cell organelle known as the lysosome, which functions at the final stage of autophagy.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).

Insulin is also known to trigger pathways of inflammation, and in some laboratory studies, it has been shown to increase the metabolic activity of cancer cells.

A study published in the Jan. 1, 2016 online issue of Cancer Research, demonstrates dietary sugar's effect on an enzymatic signaling pathway known as 12 - LOX (12 - lipoxygenase).

We know that those with metabolic states resulting from a high - carbohydrate diet — including high blood sugar levels, high insulin levels, and obesity — have higher rates of cancer and do more poorly during cancer treatment.13 — 16 We also know that multiple pathways that are downregulated by a ketogenic diet also render cells more susceptible to being killed by chemotherapy and radiation therapy.17

Rapamycin is a drug that potentially can inhibit an important pathway in cancer progression known as mTOR.