Sentences with phrase «known cells in this tissue»

«All of the known cells in this tissue remained the same, but we found a previously unidentified zone populated by unique basal progenitor cells,» he said.

Not exact matches

If you really want to know more about development and differentiation of cells and tissue... do some reading, it's pretty straight forward stuff that is well described in the literature.

The difficulties associated with obtaining nerve tissue at the correct stage of development and differentiation from aborted embryos means that foetal tissue transplantation is no longer in favour, but the creation of human embryos specifically as sources of stem cells, and the push to use «spare» embryos from IVF treatments is gatheringmomentum.

One such protein, EGF, was already high on the list of suspects due to its abundant presence in breast milk and its well - known role in promoting the growth and development of cells in various tissues.

Knowing TH17 cells need to function in a variety of tissue environments throughout the body, Sundrud's team wondered if and how these cells might use different tools to behave normally in one environment — or tissue — than they'd use in another.

It is a complicated, intricately woven tissue — like nothing else we know of in the universe — but it is composed of cells, as any tissue is.

The detector developed at UNH, known as DoSEN, short for Dose Spectra from Energetic Particles and Neutrons, measures and calculates the absorbed dose in matter and tissue resulting from the exposure to indirect and direct ionizing radiation, which can change cells at the atomic level and lead to irreparable damage.

«Knowing how cells respond to mechanical cues in the living embryo and how they physically sculpt tissues and organs in the 3D space will transform the way we think about developmental processes,» said Otger Campàs, a professor in the Department of Mechanical Engineering at UCSB and senior author on the paper that reports this novel technique in Nature Methods.

Now, with new kinds of technologies that are coming up, new types of tissue engineering and, you know, some of the hopes that people have for stem cells and [the] like, it may be interesting to see if there are other ways, alternatives to dealing with really badly damaged hearts that would involve growing a new heart or replacing or repairing the damage d to a badly damaged heart that might make artificial hearts less important in the somewhat more distant future.

In fact, recent breakthroughs in the creation of human induced pluripotent stem cells (IPS) and the engineering of biodegradable scaffolds to create tissues may ultimately be applicable to most health conditions known to humankinIn fact, recent breakthroughs in the creation of human induced pluripotent stem cells (IPS) and the engineering of biodegradable scaffolds to create tissues may ultimately be applicable to most health conditions known to humankinin the creation of human induced pluripotent stem cells (IPS) and the engineering of biodegradable scaffolds to create tissues may ultimately be applicable to most health conditions known to humankind.

The study found that the insulin - like growth factor 1 (IGF - 1) hormone, known for its pivotal role in tissue growth, is also capable of increasing the lithium sensitivity of blood cells in bipolar disorder patients in whom lithium was originally ineffective.

Moreover, the scientists have found that these stem cells depend upon a family of proteins known as the «Wnt signaling network» — the same proteins that play a crucial role in hair and tissue regeneration — to regenerate bone in the fingertip.

On the other hand, the problem is, you know, with embryonic stem cells, they haven't been able to get stem cell lines from livestock animals that can proliferate in that way, without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain tissue or bone tissue or something else.

In conjunction with bone marrow tissue cells, these HSCs form a microenvironment known as a niche.

In this study, using a mouse transgenic approach, the scientists demonstrated that ILC2s express a checkpoint molecule, known as «PD - L1», that functions to control the expansion of allergy - inducing Th2 cells and the development of allergic pulmonary and gut tissue inflammation.

«We don't yet know if this type of coordination and control works in stem cell niches of other tissue types,» says DiNardo.

«We now know much more about metabolic reprogramming of cancerous tissues in human patients, particularly that the activation of pyruvate carboxylase is important to lung cancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of Kentucky.

Not only does this let them build up complex tissue components like the mammary gland, but also to experiment with specifically adding in a single cell with a known cancer mutation to different parts of the organoid to observe its effects.

Researchers are studying how NK cells recognize cancer cells as abnormal and how other cells, known as regulatory T cells, can command NK cells to hold their fire, in order to prevent them from attacking the body's own tissues.

Therefore, it's useful for researchers to know the set of proteins present, or the proteome, in a cell or tissue at a given time and under certain conditions.

I don't know too many other consortia which can integrate expertise in embryonic and tissue stem cell biology, tissue regeneration and repair, bioengineering and nanotechnology, materials science, genomics and bio-informatics.

«We know from animal models that there are critical periods during early development when cells are rapidly dividing and forming the circuitry through which cells will communicate with each other to form various tissues of the body,» said Retha Newbold, a reproductive biologist at the National Institute of Environmental Health Sciences in North Carolina.

Mathematical models employed by the researchers suggest that the key is a molecule that inhibits branching, namely, a protein called transforming growth factor - β (TGF - β), which is produced by mammary cells and which is known to stop branching in developing tissues.

It's known that some T cell sentinels take up residence in specific tissues, including the brain, liver, intestines, skin and lungs.

Furthermore, POSTN was reported to bind to Wnt ligands, leading to an increase in Wnt signaling in CSCs, a known regulator of stem cell maintenance in a variety of tissues (Malanchi et al., 2012).

The research used skin samples from five men to create what are known as induced pluripotent stem cells, which closely resemble embryonic stem cells in their ability to become nearly any tissue in the body.

The balloon angioplasty, in addition to opening the artery can lead to smooth muscle cell proliferation, similar to formation of scar tissue, known as neointimal hyperplasia.

He wants to know how the interplay of structural, chemical, and electrical signals in and between cells of nervous tissue gives rise to behavior.

A related concern: available evidence suggests introduced cells â $ «no matter if they are primarily serving as nurses or building blocks — donâ $ ™ t survive or even stay in their target tissue for long.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

Confocal microscopy of convertases and known disease - related human convertase mutants in cells and tissues will also be used to shed light on subcellular targeting mechanisms.

Adult stem cells known as mesenchymal stem cells (MSCs) are repair cells that are found in many tissues of the body and have been studied for many years in bone marrow.

It focuses on the quantitative biophysical characterization of molecular machines, the understanding of the relevance of physical fields and forces in cell morphology and tissue formation, and the mutual enrichment of biotechnology and nanotechnology in what is known as molecular bioengineering.

«All we knew for a long time was that special immune cells called histiocytes were found in the tissue of patients who were sick,» says Melissa Hines, MD, of St. Jude Critical Care.

2D nanoparticles known as nanosilicates can be used to grow bone and cartilage tissue from human mesenchymal stem cells, according to new gene sequencing experiments by researchers at Texas A&M University in the US.

«There are positive signs that the edited cells do end up in tissues that harbour infected white blood cells carrying dormant viruses, known as reservoirs, which is where they would be most useful.

Rather, the defective checkpoint system was left to proceed, and one of its downstream consequences, which was still under normal regulation — and one known to be directly induced by the normal degenerative aging process — was reversed at the structural level, by clearing out the p16Ink4a - positive senescent cells that had accumulated to an abnormal degree in their tissues.

Stored in your adipose (fat) tissue is a type of stem cell medically known as mesenchymal stem cells (MSCs).

ANN ARBOR, Mich — By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids — made from human pluripotent stem cells — researchers have taken an important step toward creating a new technology for controlling the growth of these organoids and using them for treating wounds in the gut that can be caused by disorders such as inflammatory bowel disease (IBD).

Senescent cells lose their normal function in the tissue, cease dividing, and begin secreting a deadly mix of inflammatory and tissue - degrading factors collectively known as the senescence - associated secretory phenotype (SASP) that damages and deranges local tissues.

Blastoma: Tumors formed from embryonic tissue or developing cells are known as blastomas and are more common in children than adults.

Very little is known on SAC signaling in normal tissues in vivo, and whether distinct cell types exhibit differences in SAC activation.

In a new STEM CELLS Translational Medicine study, Zhang et al. now report that the overexpression of Platelet - Derived Growth Factor - BB (PDGF - BB), a well - known potent mitogenic, angiogenic, and chemoattractive agent, can significantly enhance dental tissue regeneration [5].

The superior performance of hNPCctx - GDNF is consistent with both the known role of GDNF as a neuroprotective molecule within the retina [25]--[30] and the established ability of hNPCctx to function as a cell - based drug delivery vector in diverse CNS tissues [11], [12].

In a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cellIn a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cellin Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ceCell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cecell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cellin the laboratory into muscle, bone and cartilage cells.

SLC16A11 belongs to a family of genes known to transport molecules across cell membranes, but the proteins that genes produce can perform many different roles in the body, and they can be active in some tissue types but not others.

Thomson still supports lifting Bush's restrictions, he said, because no one knows whether the new iPS cells can match embryonic cells» knack for growing into any kind of tissue — brain cells, heart muscle, insulin - producing cells and dozens of others — in mass quantities.

Although originally studied primarily in two - dimensional in vitro assays, most cell migrations in vivo occur in complex three - dimensional tissue environments that are difficult to recapitulate in cell culture or ex vivo Further, it is now known that cells can mobilize a diverse repertoire of migration modes and subcellular structures to move through and around tissues.

Published in Cell, BSI member Professor Adrian Hayday explains the value of his study: «We need to know how such tissue - resident immune cells sense the status of the body surface in which they sit.