Sentences with phrase «known factors related»

Not exact matches

No, the meaning of man, and the intelligibility of man, which must proceed as a factor from the very fact that man does exist, and must mean something, this intelligibility of man is related not to the Divine Essence as a claim, but only to the Divine Wisdom, as a principle of meaning for the whole of creation.

Nevertheless, space, or rather space - time, is a real and important factor in the only world we know, and we may legitimately inquire how God is related to space - time.

Many factors in our society militate against depth relationships — the frenzied pace of our lives; the frantic pressures to get ahead which encourage using rather than relating to people; the constant mobility of many families which contributes to a rootlessness and noninvolvement in community life; the anonymity of megalopolis where people do not know the names of even those in adjoining apartments.

With the advances in knowledge that are almost certain to be gained from the Human Genome Initiative — or, if its critics should win the day and it lose support, from more piecemeal genetic - research — we will know more and - more about genetic factors causally related to health and disease and to other important aspects of life, such as intelligence and emotional states.

The latest safe infant sleep recommendations are based on what experts have learned and are known risk - factors for sleep - related infant deaths.

Breastfeeding rates are closely related to economic and educational achievement, both known to be important confounding factors.

Babies starting to sleep longer is more a factor related to their growth, having a consistent bedtime routine and knowing how to fall asleep on their own, not on how full their tummies are.

An organization known as, Consumer Product Safety Commission, has reported sleep related deaths are directly attributed to certain factors like fluffy bedding, pillows in bed, parents who smoke, co-sleeping with alcohol use and heavy quilts.

It made me glad to know that if it had been the real thing, there was no way any adult in the house would sleep through it because, according to FEMA, the leading human factor contributing to fire related injuries in homes is being asleep.

We also discuss how the same underlying cultural beliefs that supported the idea that infants sleep best alone serve presently to permit the acceptance of an inappropriate set of assumptions related to explaining why some babies die unexpectedly while sleeping in their parents beds.9 These assumptions are that regardless of circumstances, including maternal motivations and / or the absence of all known bedsharing risk factors, even nonsmoking, sober, breastfeeding mothers place their infants at significantly increased risk for SUID by bedsharing.

Disabled people have long - known that non-health related factors like skills, confidence, motivation and qualifications are much stronger indicators of employment success, but the test considers none of these things.

The authors note that the different relationships between alcohol intake and various types of cardiovascular disease may relate to alcohol's elevating effects on blood pressure and on factors related to elevated high - density lipoprotein cholesterol (HDL - C)(also known as «good» cholesterol).

Yuichi Oike of Keio University in Japan and colleagues initially engineered mice that express large amounts of a protein known as angiopoietin - related growth factor (AGF) in order to study its role in forming blood vessels.

And he had some ideas; we knew from the more extreme case of polycystic ovarian syndrome that this form of infertility — it is strongly related to infertility — is due to insulin resistance, and we had also seen a lot of dietary factors being related to insulin; so he said logically, he hypothesized that maybe some of those dietary factors that are related to insulin resistance are also related to infertility, even before you get to polycystic ovarian syndrome.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Spalax naturally have a variant in the p53 gene (a transcription factor and known tumor suppressor), which is identical to a cancer - related mutation in humans, Band said.

A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of larger signaling networks that regulate development.

«In a league where hundreds of millions of dollars are lost in a year to injury, every effort should be made to control known risk factors related to injury.

However, after the other OSA - related factors were added to the model, AHI was no longer a significant predictor of the composite outcome.

Although it is known that excessive alcohol intake (more than two drinks per day) is a risk factor for stroke, there hasn't been much scientific study about how alcohol - related behavior might change after a stroke has occurred.

Although much research has examined traumatic brain injury (TBI) as a possible risk factor for later life dementia from neurodegenerative diseases such as Alzheimer's disease (AD), little is known regarding how TBI influences the rate of age - related cognitive change.

«We have long known that an activated immune system and a defective skin barrier are both important factors in eczema, but not how they are related and which one drives the disease,» said Dr. Leung.

«We know that sleep is important for cardiovascular health and many studies have linked poor or insufficient sleep with increased risk factors for cardiovascular - related diseases,» said Xiang Gao, MD, PhD, a researcher in the Channing Division of Network Medicine at BWH and Harvard School of Public Health and senior author of this study.

An international study, involving researchers at the University of Southampton and Southampton General Hospital, has significantly expanded the number of genetic factors known to play a role in age - related macular degeneration (AMD), a leading cause of vision loss among people age 50 and older.

We now know that COPD is not any more common in Aboriginal Australians than in the general population, and we suggest that smaller lung volumes are probably more related to environmental and socioeconomic factors than to genetics alone,» said Dr. Nathania Cooksley, lead author of the Respirology study.

Little is known, however, about team and individual factors related to success in synthesis teams.

It's one thing to know the human genome, but another to know what factors dictate how it relates to our observable characteristics or phenotype.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

We understand now that most of the risk for developing age - related macular degeneration (AMD) comes from environmental causes, particularly our diets and nutrition; however, we don't know why these dietary factors change the risk of AMD or how they affect our bodies.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Gastric adenocarcinoma is the second leading cause of cancer - related death in the world, and Helicobacter pylori, a bacterial species that persistently colonizes the human stomach and induces chronic gastritis, is the strongest known risk factor for this malignancy.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Many of these disorders have an age - related onset, but it is not known whether an age - related decline in neuronal hormone release is a contributing factor.

So, now that we know the underlying factors that trigger lean muscle loss as we start aging, it's time to explore few ways to combat the age - related symptoms effectively:

Exercise - related variables aren't typically used to calculate risk for conditions like heart disease — even though poor physical fitness is a known risk factor.

Seth Kaplan, an associate professor in industrial / organizational psychology at George Mason University in Fairfax, Va., said, «We know that there are some major job - related factors that contribute to poor psychological health.»

No significant relationship was found between vitamin D status and early or advanced age - related macular degeneration after making adjustments for age and other known age - related macular degeneration risk factors.

«Knowing that there may be a more rapid increase in heart - related risk factors, women may be able to increase their level of exercise and the quality of their diet to in theory counteract some of this natural rise in heart disease risk.»

But research suggests that some jobs can be more depression - prone than others for a variety of reasons, and certain work - related factors are known to be particularly bad for those already struggling with depression.

«Stress alone does not provoke or make asthma worse, unless it is in conjunction with other known risk factors such as traffic - related air pollution,» he says.

For this reason, we do not know if other study - related factors had an effect.

Many factors affect magnesium availability from foods and increase your need for magnesium even if you DO N'T suffer from any known magnesium related deficiency symptoms.

These anthocyanins, a subclass of phytonutrients called flavonoids, are known for their potent antioxidant and anti-inflammatory properties, two factors related to healthy aging and reduced risk of chronic diseases.

Besides the motivation factor, it is best to get your doubts cleared by the professionals who know everything related to fitness.

Hi Geoffrey Levens, I know this is old but I just came across something new that is a related factor but not previously mentioned.

• Through sipping water throughout the day especially if you're an ectomorph somatotype metabolic profile (see articles on Body know - how» relating to your metabolism), plus numerous other factors which all play their part.

From previous research, we know that variation in vocabulary growth relates to child characteristics like gender, and also to parental factors.

Once you know your audience, you need to consider several factors that help increase the learner's experience and how they relate to your specific audience.

Because parental education influences children's learning both directly and through the choice of a school, we do not know how much of the correlation can be attributed to direct impact and how much to school - related factors.

We know that teachers are the most influential school - related factor affecting student achievement.