Sentences with phrase «known genes involved»

The key to this understanding lies with Dll4, one of the earliest known genes involved in artery formation.

The new work, says Fitch, is consistent with his prediction — he would love to know the genes involved.

Not exact matches

Some proteins that these genes code for are known to be involved in stress and cell death.

At the time, a handful of genes were known to be involved in the engulfment of apoptotic cells but these were not sufficient to explain the whole process.

Interestingly, as many as nine of the genes have been previously associated with some vascular disease and four more are known to be involved in the regulation of vascular tone, supporting the importance of blood vessels in migraine attacks.

«We've known other people who have looked at genes involved in brain size evolution, tested them out and done the same kinds of experiments we've done and come up dry.»

Assembling alpha - beta tubulin dimers involves six known genes, Al - Bassam said.

To find out whether they had evolved to cope, Andres Moreno at Stanford University in California and colleagues looked at the variation of a gene known to be involved in water retention in the kidney, called FOXI1, in DNA samples from 20 Europeans, 20 east Asians and 20 Yoruba.

This gene is one of many known to be involved in the formation of emotional memories, and encodes an enzyme called protein kinase C -.

Two important genes known to be close to the chromosome 15 variant region are involved with DNA repair and replication and with intracellular signaling.

As a courtesy, Vogelstein, whose lab had already uncovered a fistful of genes involved in the disease, offered to test the 39 - year - old man for known mutations.

Those findings — published this week in Current Biology — suggest that the gene, known as FOXP2 is involved in learning the muscle movements necessary for speech, explains co-author Simon Fisher, a professor of molecular neuroscience at Oxford's Wellcome Trust Center for Human Genetics.

Scientists knew Apc was involved in stifling tumor formation because most colon cancers find a way to turn the gene off.

The new study also pins down the role of a gene that researchers knew was somehow involved in cellulose production in bacteria, but weren't sure how.

They also investigated if the genes were involved in any known signaling pathways.

Domestic animals from cows to dogs have undergone similar transformations, yet scientists know relatively little about the genes involved.

On closer inspection, the scientists discovered that the three genes involved in producing miR135 are located in areas of the genome that are known to be associated with risk factors for bipolar mood disorders.

But they think that by looking at some of the chemical basis of, you know, weight loss and / or weight gain, then by manipulating it — and they also look for the genes involved in these chemical signals — then they can possibly translate that into drugs for humans or just understanding better the mechanism of weight loss and weight gain.

In one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma drug.

He's eager to know whether this same set of genes is involved in social responsiveness of other animals.

The BRAF gene and the protein it makes are involved in the body's pain response, but scientists didn't know whether the gene also played a role in itch.

As an example, the current study identified and provided insight into the function of several genes, not previously known to be involved in the taste system, related to cell motility.

«What one really would like to know is what are the genes involved?»

Lymphocytes in the grafts of undifferentiated iPS cells were also expressing relatively high levels of genes known to be involved in hostile immune responses.

In contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerance.

Scientists knew a third gene was involved in species» incompatibility, but researchers had technical difficulties identifying it.

But the researchers found no significant changes in the expression of genes known to be involved in calcification from prior studies comparing strains with dramatically different calcification levels.

When these birds sing, the activity of a master gene called FoxP2 declines in a key region of the brain involved in vocal control known as Area X.

And we now know that it is the same epigenetic mechanisms that occur in brain as occur in liver, just involving, only the specifics differ — brain genes in brain, liver genes in liver.

Archibald and others caution that though Loki has genes that are involved in membrane remodeling in other organisms, no one knows for sure that they perform the same function in Loki.

In 1991, Robertson and her colleagues reported an unusual discovery involving a gene called Igf2, which is responsible for producing a protein known as insulin - like growth factor II (IGF - 2), important for the growth of many kinds of tissue in the developing fetus.

Serotonin is already known to be involved in emotion — antidepressant drugs like Prozac bind to serotonin transporters — so it makes sense to look to the serotonin transporter gene to help explain variations in people's emotions.

miR - 184 is known to suppress tumor development by regulating a variety of genes involved in cancer growth, while SND1 has been shown to play a significant role in the development of breast, colon, prostate and liver cancers.

Three simultaneous reports involving more than 32,000 participants uncovered four new diabetes - associated gene variants, bringing to 10 the number of known non-Mendelian genetic risk factors for type 2 diabetes.

The scientists also identified four homeobox genes — the kind involved in the development of body structures — which are known to specify the regions of the spine and legs.

The team of medics and scientists at the Wellcome Trust Centre for Mitochondrial Research at Newcastle University, together with international collaborators, have identified mutations in a gene, known as TMEM126B, involved in energy production in patient's muscles.

Next they tested an additional 27 genes that are known to be involved in various steps of ribosome biogenesis to verify whether SSUP was required for ESC maintenance.

The researchers found 70 never - before - seen genes that, based on their resemblance to other known genes, look to be involved in making these strains virulent.

In a study led by Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Julian Martinez - Agosto, UCLA scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in how progenitor stem cells are activated to fight infection.

One specifically involved in the death of immature eggs in the ovaries is known as the bax gene.

Looking at other genes known to be involved in hearing, they and other researchers found several others whose proteins were similarly changed in these mammals.

By working closely with the KhoeSan, a group of populations indigenous to southern Africa, the researchers have found that the genetics of skin pigmentation become progressively complex as populations reside closer to the equator, with an increasing number of genes — known and unknown — involved, each making a smaller overall contribution.

Although previous research has identified genes involved with behaviors seen in eating disorders such as anorexia or bulimia, little is known about how natural variation in these genes could affect eating behaviors in healthy people.

Many of the regions are near genes known to be involved in brain development and function.

Indiana University scientists have discovered the first known instance of a plant or animal lacking several key genes involved in energy production in cells.

The never - before - described virus did not involve the novel H1N1 but instead picked up the surface genes from the seasonal human H1N1 virus that has long infected humans and combined them with what's known as the triple - reassortant swine influenza.

Although BRAF gene fusions were well known to be involved in PLGGs, the study team found important differences in a related gene, CRAF, in which mutations can also lead to this type of glioma.

This means that reprogramming process begins, there is no longer any room for chance; the genes involved are ready to be activated and enable the successful reprogramming of all the cells.

«In addition to known disease - related genes, we have discovered seven novel genes as the cause of X-linked intellectual disability and analysed what signaling pathways in the cells each protein is involved in,» says Kalscheuer.

The researchers found that over 25 percent of index patients with normal results from commercial testing of BRCA1 and BRCA2, but with families severely affected by breast cancer, could be resolved by sequencing all genes known to be involved in breast cancer.