Even when there is no test, or
a known mode of inheritance, much can still be done to reduce the incidence of affected and carrier animals.
Genetic disorders without
a known mode of inheritance should be managed in the same way as polygenic disorders.
To do a better job, one most
know the modes of inheritance for each trait.
They are understating your breed's standard,
knowing the modes of inheritance that effect the traits to be eliminated or improved and knowing what the strengths and weaknesses are that present in your pedigrees.
Knowing the mode of inheritance and being able to positively identify carriers would be a great boon for breeders.
Not exact matches
ORDO also represents the relationship between the disorders and their genetic cause (if
known), the
mode of inheritance and associated epidemiological data (age
of onset, age
of death, prevalence).
The results can be filtered by quality,
mode of inheritance (e.g. autosomal, homozygous recessive, compound heterozygous, etc.), population frequencies and
known and expected pathogenicity according to ClinVar database and several predictors.
Little is
known about the
mode of inheritance; that is, whether they are simple as progressive retinal atrophy and sebaceous adenitis are in some breeds or are, like hip dysplasia, a complex association
of many genes.
In many breeds, the
mode of inheritance is not
known.
Modes of inheritance for these diseases are not fully
known and are likely to be complex, with multiple genes involved.
It reduced dramatically in frequency during the 1990s, probably because the
mode of inheritance was
known and a scientific paper established the presence
of the disease in the breed.
The
mode of inheritance of the other types is not yet
known.
The
mode of inheritance for PPM is not
known, so the best course
of action is not to breed dogs which have PPMs attaching to either the lens or cornea.
The
mode of inheritance is not
known, although autosomal recessive
inheritance is likely; there are no gene - based tests available.
Dogs are born with it and it is inherited, although the
mode of inheritance is not yet
known in our breed.
L -2-HGA is now
known to be transmitted by means
of an autosomal recessive
mode of inheritance.
LCP is believed to be inherited, but the
mode of inheritance is not
known.
While we
know that the problem is inherited, the
mode of inheritance is unknown.
The
mode of inheritance is not
known, nor are any genetic screening tests available.