Their analysis revealed 104 differentially regulated genes that have
known orthologs in the OA - susceptible fly
Their analysis revealed 104 differentially regulated genes that have
known orthologs in the OA - susceptible fly D. melanogaster.
Not exact matches
The
ortholog genes that were found to be associated with cartilage development, along with bmp which acts as a key member gene, are
known to be involved in the Wnt signaling pathway (Kim et al., 2013; Lin & Hankenson, 2011).
This makes them ideal to predict gene function, by transferring
known functional annotations from
orthologs in model organisms.