Sentences with phrase «known protein kinase»

Unlike the ESTs of the NIH application, these EST sequences were identified by their specific similarity to known protein kinase cDNAs.

Not exact matches

The protein, known as focal adhesion kinase, or FAK, activates an enzyme called AKT, which helps islet cells in the pancreas to survive.

They found that atypical protein kinase c lambda / iota, which is known to influence cell growth, was highly expressed and phosphorylated in metastatic breast cancers.

This gene is one of many known to be involved in the formation of emotional memories, and encodes an enzyme called protein kinase C -.

One of the more intriguing findings in the study was that increasing histone crotonylation works synergistically with other known anti-HIV latency molecules, such as the protein kinase C agonist PEP005 and the HDAC inhibitor vorinostat.

One reason may be that DDRs are protein enzymes known as tyrosine kinases that act as on and off switches of the cell self - cleaning process known as autophagy.

There are over 500 known human kinases and 10s of thousands of possible proteins they can target.

The stress hormone treatment activated a protein called FAK (focal adhesion kinase), which is known to protect cells from anoikis.

These phosphate groups are attached to proteins by enzymes known as kinases, while phosphatases act as their counterparts by removing them.

«We know dysregulation of a protein enzyme called multifunctional CaM kinase II plays a role in disrupting sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.

A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases, including certain types of leukemia, lung cancer, kidney cancer and squamous cell cancer of the head and neck.

For the new study, the research team focused on activating an enzyme known as AMP - activated protein kinase, or AMPK, which — among other roles — stimulates the breakdown of glucose for energy.

These events occur when specific extracellular molecules bind to receptor proteins in the plasma membrane known as receptor tyrosine kinases and heterotrimeric G - protein - coupled receptors.

Moreover; it has been observed that elevated calcium levels and interaction of the membrane bound DAG with protein kinase C (PKC), activates PKC's kinase activity, which is known to regulate the cellular activity of MAPK [41].

He served as a member of the graduate faculty in the Department of Molecular Biology at Princeton University and spent 10 years at NIH where he madesignificant contributions to the discovery of a class of proteins known as tyrosine kinase oncogenes as key regulators of the immune system.

The researchers also screened more than 100 anticancer compounds to see whether they killed lab - grown cancer cells from the devils and found that both strains responded to inhibitors of proteins known as receptor tyrosine kinases.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

ATM was also known to work exclusively as a protein kinase.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

First, Nanog opened two key cellular pathways, known as Rho - associated protein kinase (ROCK) and Transforming growth factor beta (TGF - β).

A recent study showed that Brazilian propolis has the ability to block the serine / theonine protein kinase known as PAK - 1.

In several clinical trials, berberine effectively stabilized blood sugar by activating a regluatory enzyme known as adenosine monophosphate - activated protein kinase, or AMPK.

This second set of experiments in cultured muscle cells showed that HMB attenuated a specific pathway involving caspase 3 and 8, PKR (RNA dependent protein kinase), and reactive oxygen species (ROS) known to activate the ubiquitin - protease pathway.