Sentences with phrase «known protein sequences»

Not exact matches

The point being that nobody knows how different the intron or non-protein coding sequences are between humans and other primates because the research quoted is only on the exons, or protein coding portions of the genome.

Using a gene - sequencing technique known as whole - exome sequencing that targets only the DNA that encodes proteins, the researchers cataloged virtually every significant DNA variant in three families in which the condition is common.

Unlike the ESTs of the NIH application, these EST sequences were identified by their specific similarity to known protein kinase cDNAs.

The shape in which a protein naturally folds is known as its native state, which is determined by its sequence of amino acids.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

For most known genes this «messenger» or mRNA is then shuttled off to a ribosome of a cell where its translation into a protein sequence occurs.

VirSorter also «fished» for sequences by looking for genes known to help produce a protein shell that all viruses have, called a capsid.

The potassium channel from Streptomyces lividans is an integral membrane protein with sequence similarity to all known K + channels, particularly in the pore region.

Now that the sequence of the PfEMP1 genes and proteins is known, it may be possible to screen for drugs to block the production of the proteins, and so prevent infected cells sticking to capillaries.

The trouble is that it's impossible to know how a protein will fold based on its gene sequence alone.

Researchers had known since the turn of the century that proteins were chains of amino acids, but Sanger came up with a way to figure out their sequence.

Three - letter genetic sequences are known as codons, and they can either code for an amino acid — the building blocks of proteins — or act as stop signals.

«Knowing the DNA sequence does not automatically tell us everything about the proteins doing work in the cells.

The sequence is an on - switch for a protein known as KIT ligand (KITLG); three previous studies have linked SNPs in this region with testicular cancer.

Then he used a computer to compare the string of amino acids making up the protein to the sequence of amino acids in all other known proteins.

This, in turn, because the scientists did not know which DNA sequences are functional, and bind to the specific proteins called transcription factors that regulate gene expression.

Cas9 uses short RNA molecules, known as guide RNAs, to target the protein to a specific sequence within cellular DNA.

The mechanism by which MNLPs modify gene activity is not yet known; a leading hypothesis is that the short sequences change a promoter's ability to bind proteins that regulate transcription.

The researchers searched hundreds of molecules for potential partners of α - catenin and turned up a new protein known only by its sequence in the human genome database: ARHGAP10.

Upon sequencing the protein, he identified it as RB47, a protein that was not known to have any RNA - cleaving ability.

Both termini of the genomic contain sequences that do not encode viral proteins, known as the 5 ′ and the 3 ′ untranslated region.

A significant proportion of SVs affect known protein - coding genes by altering coding sequence or gene dose.

We separately aligned the protein sequences of known Boule homologs among two distant metazoan groups, mammals and insects, and established a consensus sequence for the RNA recognition motif (RRM) in each group (Figure S1).

Future studies of the Arabidopsis genome and the proteins it encodes (particularly those with no known function) will be greatly facilitated by combining the new DNA sequence information with a multitude of existing genetic and molecular biological strategies and resources that are available to Arabidopsis researchers.

Although the genomic sequence of T. brucei has been reported, many of the predicted proteins lack classifiable homology to known proteins in other organisms, hindering efforts to understand its biology and discover potential therapies.

Because the gene and protein sequences of both enzymes are known, «now we can take the whole repertoire of drugs and see how they bind to PGHS - 1, predict how they might bind to PGHS - 2, and try to fashion whole new families of drugs that would be highly specific for one form or the other,» Garavito said.

When a protein sequence does not share any significant sequence similarity with a protein of known structure, homology modeling can not be applied.

This database, derived from the structural classification of proteins (SCOP), contains the sequences of proteins of known structure whose sequence identities with each other are 40 % or less.

Pairwise sequence comparison methods have been assessed using proteins whose relationships are known reliably from their structures and functions, as described in the SCOP database [Murzin, A. G., Brenner, S. E., Hubbard, T. & Chothia C. (1995) J. Mol.

Today Kvansakul's newly formed lab in the department of biochemistry at La Trobe University in Victoria, Australia, is using what he has learned about the sequences and structures of anti-apoptotic viral proteins to start developing new treatments for Burkitt lymphoma, a form of the disease known to be caused by the Epstein - Barr virus.

Our researchers will then use those samples to assess the blood cells, iron proteins and to conduct genetic testing that will sequence all the known CSA genes.

Scientists can evaluate the sequence of a protein to determine if it resembles any known allergen.

Over the last several years, sequencing patients» protein - coding genes — known as whole - exome sequencing — has facilitated molecular diagnosis and as served as a research tool for discovering the fundamental genetic bases for over 100 Mendelian diseases.