Sentences with phrase «known risk factor genes»

Sample sets were selected from well - characterized, ethnically diverse study cohorts of individuals with or without an AD diagnosis and the presence or absence of known risk factor genes.

BRCA1 and 2, genes whose proteins are supposed to work as tumor suppressors and also repair DNA damage, were the first known risk factor genes for familial breast cancer as well as ovarian and other cancers.

Not exact matches

The gene is a known risk factor for psychiatric disorders, and is required to maintain healthy neurotransmitter levels in the brain.

Inherited mutations of the tumour suppressor gene CDKN2A are the strongest known risk factors for familial melanoma and mutations in this gene also increase the risk of other cancers.

Researchers have identified a pair of genes that increase a child's risk of developing inflammatory bowel disease (IBD) before the age of 19 — adding to a growing list of 30 known genetic factors for the malady.

It can accurately identify those carrying two copies of the APOE4 gene — known to be a severe risk factor for developing Alzheimer's.

For example, genetic changes in the FCGR2 gene are known risk factors for several autoimmune disorders, including those just noted.

On closer inspection, the scientists discovered that the three genes involved in producing miR135 are located in areas of the genome that are known to be associated with risk factors for bipolar mood disorders.

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late - onset form of Alzheimer's disease, but exactly how that variant confers increased risk has been controversial among researchers.

Three simultaneous reports involving more than 32,000 participants uncovered four new diabetes - associated gene variants, bringing to 10 the number of known non-Mendelian genetic risk factors for type 2 diabetes.

Together, they looked at two well - known genetic risk factors for CKD in black people, the mutated G1 or G2 variations in the gene known as apolipoprotein L1 (APOL1).

Professor Michael Lisanti, from The University of Manchester — part of Manchester Cancer Research Centre, said: «We know that high breast density can greatly increase a woman's breast cancer risk as well as other factors such as aging, family history and presence of mutations in genes such as BRCA 1 and BRCA 2.

RORA regulates many genes linked to autism, including a gene that influences prenatal testosterone levels, a known risk factor for autism.3

Although we don't know what causes dementia, scientists have identified several modifiable risk factors aside from the APOE gene.

Vaidya suggests that genes could make these people more susceptible to known disease risk factors, or that genes could make people more vulnerable to some as - yet - unknown risk factor.

Smoking, lack of exercise, bad diet and our genes are all well - known risk factors for heart disease, cancer and diabetes.

In this review, I highlight the main genes known to cause uncommon monogenic forms of diabetes (e.g. maturity - onset diabetes of the young — MODY — and insulin resistance syndromes), as well as describe some of the main approaches used to identify genes involved in the more common forms of T2D that result from the interaction between environmental risk factors and predisposing genotypes.

Hyperinsulinemia is the strongest known risk factor in non-E4 carriers, and overcomes whatever protection their genes might provide.

«The risk factor we have identified is in a gene known to repair UV - caused damage to DNA,» said Dr. Bellone.