In her January 28, 2000 Science paper, Lindquist and postdoctoral fellow Liming Li created a novel prion by taking the prion - determining part of Sup35,
a known yeast prion, and linking it to a mammalian hormone response factor.
Sondheimer focused his search on a handful of suspect proteins that possessed regions that looked a lot like the prion - determining regions of
known yeast prions Sup35 and Ure2.
Not exact matches
Moreover, when the protein snippet was inserted into
yeast, it could replace the functions of a
known prion - forming
yeast protein.
Although
prions are infamous for causing Creutzfeld - Jakob disease, fatal familial insomnia, and bovine spongiform encephalopathy, commonly
known as mad cow's disease, the present study indicates that
prions identified in
yeast, and possibly in plants, and other organisms may be beneficial.
In a massive undertaking, Whitehead Institute scientists have tested nearly 700 wild
yeast strains isolated from diverse environments for the presence of
known and unknown
prion elements, finding them in one third of all strains.
«We already
know that two of the 6,200 proteins in
yeast can be
prions,» said Sondheimer.