Calabrese et al (1) state the following about the relationship between PD and tryptophan /
kynurenine metabolism:
Along with a discussion on PD and the gut - brain axis, no discussion on PD or any other neurodegenerative disease would be complete, as I hope I have demonstrated in previous newsletters, without a discussion on the connection with aberrant tryptophan /
kynurenine metabolism.
Next the authors mention the relationship between the gut,
kynurenine metabolism, and the overall impact on neurologic function and PD specifically:
Not exact matches
IDO is a key immunoregulatory enzyme in the
metabolism of the essential amino acid tryptophan to
kynurenine.
Stable isotope labeled L -
kynurenine (KYN)
metabolism investigated using In vivo microdialysis coupled with a novel high content LC / MS / MS method D. P. BUDAC, D. SONG, M. CAJINA, A. LEE, B. M. CAMPBELL, G. LI, C. SÁNCHEZ, C. FORRAY, V. S. PALAMARCHOUK, G. N. SMAGIN... Abstract / Posters