Sentences with phrase «lab mice as»

Mr. Merrell timed 72 male lab mice as they navigated a 5 - by -3-foot maze, and found that it took them an average of...

Although progress toward harnessing the immune system to attack tumors has been «enormous,» he said, his lab and many others are seeing in more and more studies — in lab mice as well as patients — that «immuno - oncology» will not be as simple as stimulating T cells to attack tumors.

Not exact matches

As he told the Post, it's already happening with mice in the lab.

Believe it or not, the ultra liberal look just as foolish (seriously: set the lab mice we are testing cancer treatments on free, but kill the unborn children because their mothers deserve not to have their lives ruined by stressful bundles of joy)

(It's important to remember that, to one extent or another, every item on his list has already been accomplished in the lab with other animals, We have worms living seven times as long, and mice running mazes twice as fast.

Another study published in 1999 by Anderson Laboratories found that lab mice exposed to various brands of disposable diapers experienced asthma - like symptoms, as well as eye, nose and throat irritation.

Loving points out that in her lab, many responsibilities are shared among lab members — such as breeding mice, taking care of them, and cleaning the biosafety level 3 facility.

For decades, wildlife documentaries have promoted the idea that Komodo dragons owe their success as predators to toxic bacteria in their saliva — a claim bolstered by a 2002 study reporting deaths among lab mice injected with their saliva.

Her main focus has been studying how the central nervous system develops in embryos: in frogs as a graduate student, then in mice as a postdoc at Duke University starting in 1997, and later at U.C. San Francisco when her lab moved to the Ernest Gallo Clinic and Research Center there in 1999.

Scientists had been searching in vain for such a gene since 1994 when Rockefeller University scientist Jeffery Friedman found that lab mice with a specific genetic mutation fail to produce leptin and as a result have uncontrollable appetites, and become huge.

But when Antoine Louveau, a researcher in Kipnis» lab, developed a dissection technique that wholly preserves the fragile membranes covering the mouse brain, it revealed something never seen before: Immune cells in the membranes were clearly organized, as if traveling within tubes.

In a report on the study, published Feb. 5 in Nature Neuroscience, researchers say the biochemical receptor, known as a G protein - coupled receptor, was present on nerve cells in the lower respiratory tracts of lab mice.

He and colleagues at the University of California, San Francisco, injected the brains of mice with prions they had created in the lab by misfolding normal prion protein, known as PrP.

Enormous projects such as ENCODE (for humans and mice) or modENCODE (for other lab model systems, such as the fly Drosophila or the worm C. elegans) have been devoted to collecting these data in order to analyse and interpret them in the framework of genomic data and to form hypotheses about functions and relations.

But as Mario Capecchi of the University of Utah, Sir Martin Evans of Cardiff University in Wales, and Oliver Smithies of the University of North Carolina proved in 2007 with their Nobel Prize — winning work on mice, homologous recombination can also be achieved in the lab.

They have since learned that as many as 40 of those lines may never be fully developed; some may even have been contaminated by mouse cells used to sustain them in the lab.

Lazar, co-first author Matthew Emmett, an MD / PhD student in his lab, and their IDOM colleagues found that mice lacking HDAC3 in their brown fat were unable to turn on the UCP1 gene and were just as susceptible to the deleterious effects of cold as mice that did not have the gene.

A Johns Hopkins University team this week reported inserting a disrupted human gene, the schizophrenia risk factor DISC1, into lab mice, causing them to exhibit the brain asymmetry characteristic of schizophrenia as well as agitation in open spaces and trouble finding hidden food — traits reminiscent of the restlessness, impaired sense of smell and depressionlike symptoms schizophrenics suffer, Reuters reports.

These findings were confirmed by two - photon imaging of neurons in the brains of living mice by the lab of collaborator Yi Zuo, PhD, a neuroscientist at UC Santa Cruz, as well as electrophysiological recordings from neurons in brain slices by the lab of collaborator Vikaas Sohal, MD, PhD, an associate professor of psychiatry at UCSF.

As expected, biochemical experiments in the Cheyette lab revealed that DIXDC1 mutations impaired WNT signaling in neurons from affected mice.

As they develop human clinical trials, Wargo and colleagues also are conducting lab and mouse model research to better understand the mechanisms that connect bacteria and the immune system.

As controls, fibroblasts and secretions from normal lab rats, mice, and another rodent called the spiny mouse were powerless to stop the human cancer cells growing.

Their study, published in the ACS journal Chemical Research in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth of human breast cancer cells in lab dishes and breast cancer tumors in mice.

Next, they showed that deer mice and oldfield mice build the same kinds of burrows in the lab as in the wild — two very different environments.

They found almost no correlation between the nanoparticles identified as promising in the lab dish tests and those that actually performed well in the mice.

«It's a nasty virus if you're a mouse» but doesn't sicken humans, Steel says of this 80 - year - old lab strain, known as PR8.

Indeed, lab studies have shown that as many as 90 % of ticks feeding on an infected mouse pick up the bug, an «extremely high number,» says disease ecologist Dustin Brisson of the University of Pennsylvania.

As a result, lab mice thrived.

Working in the lab and the clinic, Narayanan and his team record brain activity in mice and humans as they do simple timing tasks.

In experiments with lab mice, she discovered how small groups of cells dance about to form an embryo and how a layer of cells surrounding the embryo itself, previously thought of as nothing more than a protective cloak, orchestrates the formation of an embryo's body parts.

«In our mouse experiments, olive oil produced essentially identical effects as Plenish — more obesity than coconut oil, although less than conventional soybean oil — and very fatty livers, which was surprising as olive oil is typically considered to be the healthiest of all the vegetable oils,» said Poonamjot Deol, an assistant project scientist working in Sladek's lab and the co-first author of the research paper.

In lab tests, they found that the bacteria aren't as virulent when a mouse isn't eating, and they use the vagus nerve, a superhighway connecting gut to brain, to encourage eating.

Last year, as a first step in defining a «normal» lab mouse microbiome, they analyzed feces from mice from two major vendors.

Earlier this year, his lab brought in its own «dirty» colony from a company that sells mice as food for zoo animals.

Mogil's lab developed pain grimace scales for rats and mice in 2006, and it discovered that mice experience pain when they see a familiar mouse suffering — a psychological phenomenon known as emotional contagion.

«The thing that's impressive is that morphological changes in the neurons that many labs have seen, both in fragile X patients as well as in mice that model fragile X, were reversed by changing the expression of this PAK gene.

A compound used in many common plastic products, including baby bottles and dental sealants, causes genetic abnormalities in mice, say researchers who made the discovery as a result of a mix - up in the lab.

The cell cultures in the petri dishes are of human origin, and in some aspects resemble human brains more than the brains of lab animals such as rats or mice do.

A large - scale study of two strains of lab mouse by Viola André, Martin Hrabé de Angelis and co-authors shows that the inclusion of nesting material and shelters as environmental enrichment does not impair the scientific assessment of a battery of 164 physiological parameters in mice.

The immunological benefits from the wild mice's gut bacteria may, in part, explain a persistent problem in disease research: Why disease experiments in lab mice, such as vaccine studies, turn out very differently in humans or other animals.

A study by Stephen Abolins, Mark Viney and colleagues of the immune ecology of wild house mice — the same species as the lab mouse — shows that their immune state is promoted by individuals» body condition and constrained by their age.

Even then, the proof - of - concept system — which his lab at Brown has since completely remade — annotated basic mouse behaviors as well as people did.

To find out, Einstein's George Karagiannis spent nearly three years experimenting with lab mice whose genetic mutations make them spontaneously develop breast cancer, as well as mice given human breast tumors.

As New Lab Complex Scientific Coordinator & Mouse Management Liaison, Colleen Silan is managing many aspects of the project.

Even as he sought the truth day in and day out, peering into mice brains in the lab to figure out the mysteries of addiction and depression, Jaime Maldonado - Aviles was filled with uncertainty.

Using a small fragment of apolipoprotein B as a guide, Brian Spencer, a postdoctoral fellow in the Verma lab and the study's lead author, successfully shepherded the enzyme glucocerebrosidase into the brains of adult mice.

To answer basic research questions like these, investigators study bacteria, viruses, fungi, animal cells and human cells (both healthy and cancerous) grown in the lab, and tumors in animals, such as mice and rats.

In 2015, Olivova joined the Max Planck Florida Institute for Neuroscience (MPFI) as a Max Planck Scholar, where she gained extensive lab experience by studying motor learning behaviors in mice.

By examining the results of genome - wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

As Kissler's lab began to examine whether pTregs play a role in diabetes, the scientists first looked for these cells in the non-obese diabetes (NOD) mouse model of type 1 diabetes.