Sentences with phrase «lab mice with»

Lab mice with dopamine deficiency are so deprived of motivation to eat that they starve to death even though food is available all the time (>).

The enhanced endurance was seen in lab mice with a normal oxygen supply and those with oxygen restrictions which provided significant evidence that GW501516 targets and enhances skeletal muscle endurance and recovery time to a supraphysiological level.

The study, run by Washington University and the University of California San Diego, used 33 lab mice with glioblastoma, an aggressive form of brain cancer.

Young said Celltex did a study in which it injected lab mice with 73 times the normal dose of 200 million cells that Celltex gives its clients, and none of the mice died, developed toxic organs or grew tumors.

The company has created an antibody that neutralizes a primary viral protein, and it works in lab mice with MS. «We have terrific effects,» Perron says.

Concerned that the immune systems of clean mice might not be good proxies for the human immune system — no human is brought up in such clean conditions and fed such clean food — they housed lab mice with mice from a pet store.

Scientists had been searching in vain for such a gene since 1994 when Rockefeller University scientist Jeffery Friedman found that lab mice with a specific genetic mutation fail to produce leptin and as a result have uncontrollable appetites, and become huge.

The researchers mimicked cosmic - radiation exposure by briefly bombarding the brains of lab mice with high - energy particles.

Not exact matches

As he told the Post, it's already happening with mice in the lab.

Most of its fellows collaborate with universities that generate fresh data from «wet» labs — the ones with autoclaves and genetically engineered mice — and other facilities.

(It's important to remember that, to one extent or another, every item on his list has already been accomplished in the lab with other animals, We have worms living seven times as long, and mice running mazes twice as fast.

«We've little mini lab mice, our kids, who are going into this huge untested experiment,» Astorino said, during an interview with public radio and television in April..

In the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diet.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

Scientists» long relationship with lab mice has been one of incremental advances to improve a flawed system.

For decades, wildlife documentaries have promoted the idea that Komodo dragons owe their success as predators to toxic bacteria in their saliva — a claim bolstered by a 2002 study reporting deaths among lab mice injected with their saliva.

Next, they grafted this lab - grown gene - altered skin onto mice with intact immune systems.

Raymond Schuch, a former postdoctoral researcher in Fischetti's lab, tested the inhibitor in mice infected with Bacillus anthracis.

«Every day we came into the lab and found something new with these mice, it was just the most incredible adventure.»

That's what the lab mice in a room stacked with nearly 900 cages on UM's medical campus deal with every time staff pick them up to clean their enclosures.

Next, the team tested the GD2 CAR - T cells in mice whose brainstem was implanted with human DIPG tumors, an experimental system that Monje's lab pioneered.

That would be getting close to the number of cells in a mouse brain,» raising the distant prospect of a human brain organoid with cognitive and even emotional capacities, all while sitting in a lab dish.

Altogether, about 92 % of the «dirtied» mice survived the flu, compared with just 17 % of «clean» lab mice, the researchers report today in Cell.

The gut bacteria from the wild mice were fairly similar, but the microbiomes of the lab mice were significantly different, with fewer Bacteroidetes and Proteobacteria, for example.

Barbara Rehermann and Stephan Rosshart first collected 800 wild house mice (Mus musculus domesticus) in the Washington, D.C., metro area, and compared their DNA and gut bacteria both with a lab mouse strain and with wild mice from all over the world.

Semi-starved lab mice will not only live about 25 percent longer but will run a maze at three years with the facility of a well - fed mouse of six months.

With collaborators from India, Japan, and the United States, the inStem lab is exploring «biochemistry, biophysics, humanized mouse models, and single - cell models.»

The researchers tested that idea by infecting newborn mice (which developmentally resemble a human fetus) with different lab - made versions of Zika.

He and colleagues at the University of California, San Francisco, injected the brains of mice with prions they had created in the lab by misfolding normal prion protein, known as PrP.

With the move to India, Colleen left the lab bench so that she could coordinate the development of facilities at inStem; this included new laboratory space and an animal facility housing mice, rats, fish, and frogs.

Diamond's lab circumvented this problem by creating female mice that had a key interferon gene knocked out; in a second experiment, they treated pregnant animals with an anti-interferon antibody.

When I'm not writing about science and playing with mice in the lab, I am probably writing about science and playing with mice at home.

Franco is also collaborating with a researcher who came to his lab seeking help in refining his mouse models for diabetes.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

Mouse brain nerve cells (green) making a disease - causing version of the tau protein were grown in lab dishes with supporting brain cells called glia.

The mouse models of autism on a normal lab diet (with a medium glycemic index) are already known to generate fewer new neurons, and some of their existing cells and neuronal connections are abnormal compared with those of normal mice.

In a remote Turkish village, researchers have located a family with a mutation in the leptin gene similar to the one found in lab mice, and — just like the mice — adults with two copies of the mutation are grossly overweight and don't ever go through puberty.

In collaboration with Ding, the lab of Olivier Voinnet at the Swiss Federal Institute of Technology in Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis virus.

Hajishengallis's and Chavakis's labs had previously utilized mice that lack Del - 1 alone or Del - 1 together with other molecules of the immune system.

«Based on our findings, we think mice with these ASD - associated gene mutations have a major defect in the «volume switch» in their peripheral sensory neurons,» says first author Lauren Orefice, a postdoctoral fellow in Ginty's lab.

But when he reexamined those original samples again in the summer of 2011, Silverman discovered that all seven were contaminated, not with mouse DNA but with an infectious molecular clone originally made in his own lab in 2006.

The tumors in Sand's lab might be explained by the high dose, the fact that the mice were newborns, and the type of mouse, suggests Kay, who was involved with a past clinical trial administering AAV to the liver to treat hemophilia.

Now, a preclinical study, from the lab of Olivier Berton, PhD, an assistant professor in the department of Psychiatry, in collaboration with Sheryl Beck, PhD, a professor in the department of Anesthesiology at Children's Hospital of Philadelphia, found that bullying and other social stresses triggered symptoms of depression in mice by activating GABA neurons, in a never - before - seen direct relationship between social stimuli and this neural circuitry.

«The reality is that people with PTSD are a lot more complex than mice in a lab, and someone with PTSD may be on a variety of antianxiety medications, antidepressants or even sleep aids,» he says.

In another study of mice injected with GDF11, postdoc Lida Katsimpardi and others in the lab of Harvard neuroscientist Lee Rubin found that GDF11 also encourages growth of new blood vessels and olfactory neurons in the mouse brain.

More recently, Wagers's lab, together with cardiologist Richard Lee's lab at Brigham and Women's Hospital in Boston, isolated a specific protein from mouse blood that they think can explain some of the effects.

Last year in Cell, Wagers's and Lee's labs reported that injections of GDF11 can reduce the thickening of the heart that typically comes with aging in mice.

But as Mario Capecchi of the University of Utah, Sir Martin Evans of Cardiff University in Wales, and Oliver Smithies of the University of North Carolina proved in 2007 with their Nobel Prize — winning work on mice, homologous recombination can also be achieved in the lab.

The lab of co-author Rafi Ahmed, director of Emory Vaccine Center, has reported analogous cells in mice with chronic viral infections.

Geneticist Jiří Forejt of the Czech Academy of Sciences» Institute of Molecular Genetics in Prague wasn't looking for it when he caught wild mice and bred them with lab mice to study diversity of immune system genes.