Sentences with phrase «lab mouse models»

In the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diet.

Mitchell's prior analysis examined lab studies that used an Alzheimer's lab mouse model that did not allow for the study of p - tau.

Not exact matches

However, Walker Jackson, a former postdoctoral researcher in Lindquist's lab is changing that, creating novel mouse models of human fatal familial insomnia (FFI) and CJD.

And Duff's lab has unpublished data suggesting that trehalose lessens tau pathology and improves behavior in mouse models of neurodegeneration.

Working in the Ferguson lab where Ribeiro was a postdoctoral trainee, the scientists crossed two mouse models.

The latest findings build on previous work by Dr. Habib's lab showing that the same combination of drugs was successful in a mouse model of glioblastoma, a deadly type of brain cancer.

With collaborators from India, Japan, and the United States, the inStem lab is exploring «biochemistry, biophysics, humanized mouse models, and single - cell models.»

Franco is also collaborating with a researcher who came to his lab seeking help in refining his mouse models for diabetes.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

The mouse models of autism on a normal lab diet (with a medium glycemic index) are already known to generate fewer new neurons, and some of their existing cells and neuronal connections are abnormal compared with those of normal mice.

Realizing they might have a potentially effective drug on their hands, Bogyo and his colleagues brought in Sonnenburg, whose lab is adept at using mouse models of C. difficile infection.

To examine the role for endocannabinoids generated in peripheral organs in controlling the overeating of western diet, DiPatrizio and coauthor Donovan A. Argueta, a bioengineering Ph.D. student in his lab, used a mouse model of western diet - induced obesity (chronic exposure to high levels of sugars and fats).

Enormous projects such as ENCODE (for humans and mice) or modENCODE (for other lab model systems, such as the fly Drosophila or the worm C. elegans) have been devoted to collecting these data in order to analyse and interpret them in the framework of genomic data and to form hypotheses about functions and relations.

He returned to St. Louis and shifted several members of his lab to studying Zika, including developing mouse models of the disease.

She uses lab models, including cell cultures and mice, to study these diseases.

Because the amount of fibrosis in the liver is associated with a greater risk of death from NASH, Xiaobo Wang, PhD, associate research scientist in the Department of Medicine at CUMC working in the lab of Ira Tabas, MD, PhD, looked for ways to stop fibrosis in a mouse model of NASH.

As they develop human clinical trials, Wargo and colleagues also are conducting lab and mouse model research to better understand the mechanisms that connect bacteria and the immune system.

«Observing the changes in the architecture of islets during embryonic development in mice and in pseudoislets — a model we generated in our lab — was also very interesting.

Last year, the Li lab published a paper in Journal of Clinical Investigation showing that CRISPR - Cas9 gene editing, delivered by viral vector, can reverse signs of HD in a mouse model.

Ward's lab team took skin tissue samples from her well - established psoriasis transgenic mouse model, called the KC - Tie2 mouse, and compared it to skin tissue samples of normal mice.

The lab's resident mouse whisperer, newly minted neuroscientist Kimberly Maguschak, will run some tests she uses in her quest to build a better mouse model of anxiety and depression.

«By decreasing ROS levels within a chronic wound in a diabetic mouse model, my lab was able to normalize conditions and heal the wound,» Martins - Green said.

To determine how ESRP1 mutations cause hearing loss Alex Rohacek, a graduate student in the Epstein lab, evaluated embryos in which Esrp1 was deleted in a mouse model developed by the Carstens lab.

«The thing that's impressive is that morphological changes in the neurons that many labs have seen, both in fragile X patients as well as in mice that model fragile X, were reversed by changing the expression of this PAK gene.

In previous research, Quaggin's lab showed that deleting the gene in mouse models led to glaucoma, but the scientists didn't know how mutations impairing the gene affected humans.

TOKYO — One of science's favorite lab animals, the mouse, is about to become an even more useful model system.

For years, researchers had difficulty modeling metastatic prostate cancer in mice, making it hard to study the disease in the lab.

To this aim we generated new conditional knockout mouse strains, which are currently analyzed to unravel the mechanism of a recently discovered unexpected protective role of TNFSF14 / LIGHT by our lab in an Inflammatory Bowel Disease (IBD)- like mouse model.

Scientists in the lab of Steve Finkbeiner, MD, PhD, discovered that modifying the huntingtin protein prevented cell death and motor impairment in a mouse model of Huntington's disease.

For instance, my lab, in collaboration with others, has shown that in a mouse model of TSC, neurons are sized abnormally, are not sufficiently myelinated and are prone to cell death.

Since its creation in 2002, more than 1300 mouse models were done for our customers: academic labs, European Union or big pharmaceutical groups.

The lab will study mouse models of inherited RPE - driven disease, collecting and analyzing extensive genetic and physiological data throughout disease progression.

«We are now able to model human blood function in so - called «humanized mice»,» said George Daley, head of a research lab at Boston Children's Hospital and the main architect of the experiment, in a statement.

My lab has generated mouse models to explore the function of BIN1 in the brain.

My lab has generated mouse models to mimic the increase or the decrease of BIN1 protein isoforms in the brain.

Now, a new STEM CELLS study from the labs of Qing - Ling Fu (Sun Yat - sen University, Guangzhou) and Zhongquan Qi (Xiamen University, Fujian, PR China) has described the effect of iPSC - MSCs on immune T cells in a relevant in vivo mouse model.

For this study, Jabri and colleagues combined insights and data from celiac disease patients who had been cared for at the University of Chicago's Celiac Disease Center with experiments using a mouse model of the disease developed in her lab.

With the help of conditional and function - selective knockout mice for the glucocorticoid receptor (GR) the lab identified critical cell types and novel mechanisms for anti-inflammatory activities of glucocorticoids in different inflammatory disease models.

The Verdin lab is currently exploring beneficial effects of a similar ketogenic diet in a mouse model of Alzheimer's disease.

The two labs are now collaborating on further studies of the new enzymes — and the potential benefits of inhibiting them — in mouse models of diabetes, inflammation and autoimmune disease.

«This mouse strain is great model for this research because they are otherwise healthy and normal, including in their vision, so it allows us to conduct studies focused on cell integration,» said the publication's lead author, Jie Zhu, PhD, a postdoctoral researcher who started in Lamba's lab three years ago.

Berkeley Lab researchers have developed the first clinically - relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.

This approach has led to the finding that activated fibroblasts in the tumor stroma mediate immune suppression in several mouse models of cancer, including the autochthonous model of pancreatic ductal adenocarcinoma of the Tuveson lab.

The lab recently developed novel LumiFluor ® optical reporters and are now implementing these reporters for the non-invasive, high resolution in vivo optical imaging of tumor development, progression, and response to therapeutic intervention in genetically engineered mouse models (GEMM) of cancer.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

For instance, his lab created a mouse model in which neurons in the striatum (an area of the brain that talks to the basal ganglia) could be controlled with light.

Work from his lab shows a vascular depletion in the muscle of both SMA mouse models and patients.

Eventually, the two to three most promising nanoparticle - analog combinations will be tested on mice models that replicate AML in Frisch's lab.

As Kissler's lab began to examine whether pTregs play a role in diabetes, the scientists first looked for these cells in the non-obese diabetes (NOD) mouse model of type 1 diabetes.