Not exact matches
The technique, named
cell type specific labeling using amino acid precursors (CTAP), exploits the inability of vertebrate
cells to synthesize essential amino acids normally required for growth and homeostasis.
The researchers then attempted to see if the
cells, which they
labeled multipotent adult germline stem
cells (maGSC), would differentiate into
specific types of body
cells.
Labeled antibodies, which bind to
specific cell types, allowed the researchers to determine which
types of neuron were being created at which times.
Because
type III
cells appear to integrate information from other receptor
cells (Tomchik et al., 2007) and use the 5 - HT3 system to transmit information, these previous nerve recording studies may have inhibited transmission of integrated cross-modal information from
type III
cells, leading to the appearance of strict
labeled - line, modality -
specific transmission of information.
With the recent development of transgenic mouse models, which allow
labelling and manipulation of
specific cell types, more and more emphasis has been placed on the tissue scale: How does the collective behavior of many
cells gives rise to the architecture that is characteristic for given kind of tissue?
«It tells you about the ecosystem of the tumour», Simona says, «using fluorescent markers, we can
label many
specific cell types and structures within the brain in the vicinity of the tumour, and look not just at the tumour
cells but how they interact with their surroundings.
Tang wondered if he could use previously established mouse lines expressing GFP in
specific cell types to do more than just
label cells.