Sentences with phrase «laboratory animal model»

Thus, we turned to the laboratory animal model, the mouse, for an in - depth gene expression and functional analysis.

We are cautiously optimistic, appreciating that the transition from laboratory animal models to the clinical setting is often challenging,» commented Dr. Davis.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

Currently IDOBRU imports 66 Brucella vaccines from the Vaccine Ontology (VO; http://www.violinet.org/vaccineontology [21], including four licensed animal Brucella vaccines and 62 Brucella vaccine candidates that have been proven effective in laboratory animal models [33].

Research Diets, Inc is the leading manufacturer of custom, purified OpenSource diets and scientific instrumentation for Biological Data Acquisition in laboratory animal models worldwide.

Not exact matches

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

A raft of studies in laboratory animals, molecular models and cancer patients suggest that pain drugs given during and after cancer surgery stimulate the growth and spread of certain tumors.

The laboratories also collaborated to successfully prove that reversing a protein deficiency through gene therapy is effective in improving and stabilizing SMA in a large animal model.

While most research studies begin in test tubes, cells grown in the laboratory and animal models before moving to humans, the opposite is true here.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

«There hasn't been a good animal model for any kind of speech disorder,» says study author Wan - chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal Behanimal model for any kind of speech disorder,» says study author Wan - chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal BehAnimal Behavior.

In five other studies published over the past year, Taffe, Dickerson and their laboratories have looked at the effects of MDPV and a related «bath salts» cathinone derivative, mephedrone, in a range of animal models.

His laboratory already has shown that by inhibiting calcium channels in T - cells, they were able to prevent T - cell activation in animal models of autoimmune diseases like multiple sclerosis and colitis.

I recently challenged my laboratory staff to think of animal models that could teach us about the biology of joyfulness.

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

Such ease of use will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workanimal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workAnimal Use (which organized the workshop).

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

The researchers then tested the capacity of the modified cells to kill human multiple myeloma cells in laboratory studies and an animal model.

«We had previously shown that antiangiogenesis therapies were ineffective in animal models of lymphatic metastasis, but there was no data to explain the mechanism behind those observations,» says Timothy Padera, Ph.D., of the Steele Laboratory of Tumor Biology in the MGH Department of Radiation Oncology, senior author of the paper.

However, the genetic techniques used to block Hhat in the laboratory are not possible with animal models or humans.

«This is the first study to demonstrate that functional muscle cells can be created in a laboratory and restore dystrophin in animal models of Duchenne using the human development process as a guide.»

The researcher reminds us that the study of the modelling, organisation and coordination of the animal behaviour is a clear example of multidisciplinary collaboration: «biologists participate to perform the experiments in the laboratory and provide real data, in coordination with mathematicians and physicists who propose and solve the models.»

The laboratory - based study of animals and cells (known as disease models) can be a powerful method for understanding illness.

URBANA, Ill. — Years of research in University of Illinois scientist John Erdman's laboratory have demonstrated that lycopene, the bioactive red pigment found in tomatoes, reduces growth of prostate tumors in a variety of animal models.

There is an urgent need for better animal models for laboratory research to study the Zika virus and potential treatments.

One reason is that the clinical tests used in patients minimally resemble the laboratory tests used to probe cognitive aspects of AD in animal models (5).

The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

Dr. Chartoff's Neurobiology of Motivated Behavior Laboratory, founded in 2009, investigates the molecular, biochemical, and cellular mechanisms underlying drug dependence and withdrawal using animal behavioral models with high relevance to the human condition.

The experiments have been carried out using Xenopus laevis oocytes, an animal model used by the laboratory to study fundamental processes involved in gene regulation.

Once this work is completed, a second stage is committed, in which researchers of I - Stem, in collaboration with specialists in animal models of diseases targeted by the therapeutic explore the effects of experimental transplantation of cells obtained laboratory.

The following profile of REGEN2017 student Susannah Kassmer, Ph.D., appears in the fall edition of the MDI Biological Laboratory's «Breaking Through» magazine, which focuses on how the study of highly regenerative animal models can help science understand the potential for regeneration in humans.

Where possible, we replace our animal experiments with in vitro models, such as organoids, reducing the number of laboratory animals.

Professional Experience 1983 — 1986 Research / Teaching Assistant, Exercise Physiology, University of Texas, Austin TX 1986 — 1990 Assistant Instructor / Research Assistant, Cell Biology, Developmental Biology, and Vertebrate Physiology, University of Texas, Austin TX 1993 — 1994 Visiting Assistant Professor, Department of Animal Sciences, Oregon State University 1994 — 1996 Technical Services Advisor, Genetic Resources, The Jackson Laboratory, Bar Harbor ME 1996 — 1998 Manager, Technical Services, The Jackson Laboratory, Bar Harbor ME 1997 — 1998 Assistant Professor, Adjunct, New Mexico Highlands University, Las Vegas NM 1998 — 2000 Senior Technical Information Scientist, The Jackson Laboratory, Bar Harbor ME 2000 — 2002 Senior New Models Development Scientist, The Jackson Laboratory, Bar Harbor ME 2002 — 2004 Associate Director of Genetic Resources, The Jackson Laboratory, Bar Harbor ME 2004 — 2005 Associate Research Scientist, The Jackson Laboratory, Bar Harbor ME 2004 — 2009 Assistant Professor, Dept. of Biology, New Mexico Highlands University, Las Vegas NM 2009 — 2014 Associate Professor, Dept. of Biology, New Mexico Highlands University, Las Vegas NM 2014 — present Professor, Dept. of Biology, New Mexico Highlands University, Las Vegas NM

Researchers have established a strong genetic component for addictive behaviors through studying animal models, including laboratory mice.

General Product Information Obesity - High Fat Diets for Diet - Induced Obesity Models Metabolic Syndrome - Diet - Induced Metabolic Syndrome in Rodent Models Diabetes - High Fructose / Sucrose Diets for inducing Hypertriglyceridemia and Insulin Resistance in Rodents Atherosclerosis - Diet - Induced Atherosclerosis / Hypercholesterolemia in Rodent Models Hypertension - Phenotypic Expression of Hypertension in Rodent Models through Dietary Manipulation NAFLD (Non-alcoholic Fatty Liver Disease) Cancer - Creating a Clean Background for Oncology Research Test Compounds / Kaolin Pellets Diet and Immunology Focus: Arsenic in Grain - Based Laboratory Animal Diets and Effects on the Rodent Toxicological Phenotype Focus: The Importance of a Proper Control Diet

We have learned a fair amount from the neurologic genetic diseases, but we and others also studied these cells in the laboratory as well as in animal models of brain injury.

Subsequently, work in the Markou laboratory showed that these compounds had desirable effects on nicotine dependence in animal models, while offering a better side - effect profile than other alternatives under study (full agonists at the same receptors).

Dosing Animals Via Diet Measuring Food and Water Intake in Rats and Mice Laboratory Animals - A Critical Part of In Vivo Research Diet - Induced Metabolic Syndrome in Rodent Models

In laboratory experiments, first in animal models and then in greater detail in the petri dish, the researchers tracked Arc's movements.

Researchers at the MDI Biological Laboratory have been using animal models beyond the well - known laboratory mouse foLaboratory have been using animal models beyond the well - known laboratory mouse folaboratory mouse for decades.

One potential reason for this discrepancy is that the laboratory tests used in animal models of the disease do not resemble the clinical assessments given to patients, and thus are not predictive of human memory performance.

But now scientists in the laboratory of Gladstone Institutes» Investigator Sheng Ding, MD, PhD, harnessing the power of regenerative medicine, have developed a technique in animal models that could replenish the very cells destroyed by the disease.

Through «heart - on - a-chip» technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure on functions of heart tissue using microelectrodes — Lawrence Livermore National Laboratory (LLNL) researchers hope to decrease the time needed for new drug trials and ensure potentially lifesaving drugs are safe and effective while reducing the need for human and animal testing.

«We have lots of good animal models in the laboratory that we can study.

In this way, in - depth immunological monitoring, genetic and proteomic analyses, and biomarker discovery from patient samples guides further laboratory investigation, where mechanistic studies can be designed and animal modeling performed.

The core facility is a two - photon in vivo imaging platform developed at the Nonlinear bioimaging laboratory, a technique that allows for non-invasive structural and functional measurements in small animal models at different scales: from macroscopic imaging of the brain morphology to highly resolved microscopy of neuron populations, single neurons, and even subcellular structures.

Making use of cell and animal models, my laboratory group addresses some of the fundamental questions of how ethanol exposure injures the liver, with a goal ofidentifying the individual targets of ethanol - induced injury and the specific responses of the key cell types within the liver, as well as the integrated, organismal response to this ethanol - induced injury.

We discovered several Eph receptors and ephrins, and research in our laboratory is dedicated to the characterization of Eph receptor signal transduction mechanisms and biological functions using biochemical, mass spectrometry, molecular biology and cell biology approaches in conjunction with animal models.

The dual appointment allows him to conduct experiments that compare genetic programming in the highly regenerative animals used as models at the MDI Biological Laboratory with genetic programming in neonatal and adult mice.

Laboratory of Animal Models.