PHILADELPHIA - Using a novel synthetic platform for creating vaccines originally developed in the laboratory of David Weiner, PhD, a professor of Pathology and
Laboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinical trial.
Using a novel synthetic platform for creating vaccines originally developed in the laboratory of David Weiner, PhD, a professor of Pathology and
Laboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinical trial.
Not exact matches
No longer solely the purview of makers, technological tinkerers, expensive
laboratories and tech geeks, 3 - D printing is quickly becoming the next big thing in technology, finding a significant foothold and making itself indispensible in industries ranging
from medicine to tech accessories to farming.
And the consequent technologies (X-ray,
laboratory test, EKGs, etc.) that allow
medicine to consider diseases at a distance
from the patient.
From the Channing
Laboratory, Department of
Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Departments of Nutrition and Epidemiology, Harvard School of Public Health — all in Boston (D.M., A.A., M.J.S., W.C.W.); and the Division of Human Nutrition, Wageningen University, and Wageningen Center for Food Sciences — both in Wageningen, the Netherlands (M.B.K.).
Also at the NUS, the
Laboratory for Biomedical Engineering focuses on research efforts in biomedical engineering between and among the various centres and groups
from the engineering,
medicine, dentistry, and science faculties.
Remarkably, researchers
from the Department of
Laboratory Medicine and Pathobiology (LMP) have defined potential treatment targets for this relatively common cancer — providing hope for future patients.
«It has required expertise
from across the agency, including subject matter experts in pregnancy and birth defects, sexually transmitted infections, mosquito control,
laboratory science, travelers» health, virology, transfusion
medicine, and communication science,» he added.
The first results could come out later this year and confirm that different
laboratories can get the same results
from the same cells, says Arthur L. Beaudet of the Baylor College of
Medicine, the project's data hub.
Martinez earned his PhD in Microbiology and Immunology
from Albert Einstein College of
Medicine in 2006 and has completed scholarly work at the Woods Hole Marine Biological
Laboratory and Cold Spring Harbor Laboratories.
New Scientist also arranged for samples
from the four individuals to be tested at another
laboratory, led by Denise Syndercombe Court of Barts and the London School of
Medicine and Dentistry.
In conjunction with the
laboratory of Matthew J. Evans, PhD,
from the Department of Microbiology at Icahn School of
Medicine at Mount Sinai, investigators demonstrated the functionality of the liver cells generated
from the progenitors, as the liver cells can be infected by the hepatitis C virus, a property restricted to liver cells exclusively.
Working in the
laboratory of Heather A. Hundley, corresponding author on the paper and an assistant professor of biochemistry and molecular biology in the IU School of
Medicine's Medical Sciences Program at Bloomington, Washburn and undergraduate Medical Sciences program student Emily Wheeler collaborated with the team
from UCSD to show that the region of ADR - 1 protein that binds to target mRNAs in C. elegans is also required for regulating editing.
Dr. Atkinson began her career at the University of Pennsylvania School of
Medicine, where she was Assistant and then Associate Professor and Director of the hospital's cytopathology
laboratory from 1978 to 1987.
Focusing on flu outbreaks in the U.S. between 2003 and 2008, Justin Ortiz
from the Division of Pulmonary and Critical Care
Medicine at the University of Washington and colleagues
from CDC and PATH, a Seattle - based nonprofit health organization, found that Google Flu Trends deviated greatest
from CDC surveillance figures for
laboratory - confirmed flu rates during the 2003 — 2004 flu season, which saw a high number of flu - related deaths in children and, as a result, was a hot topic in the media.
«Our
laboratory investigates the metabolic effects of nicotinamide adenine dinucleotide [NAD +], a metabolite derived
from a form of vitamin B3 called nicotinamide,» explained senior author Pavlos Pissios, PhD, an investigator in the Division of Endocrinology, Diabetes and Metabolism at BIDMC and Assistant Professor of
Medicine at Harvard Medical School.
The study was funded by grants
from Federal Ministry of Education and Research, Germany; National Institutes of Health (EY018213, EY001919, EY020846, DK042394, DK088227, and HL052173); Foundation Fighting Blindness; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital; NHS Foundation Trust; UCL Institute of Ophthalmology; Fight For Sight; Moorfields Eye Hospital Special Trustees; and Barbara & Donald Jonas
Laboratory of Stem Cells and Regenerative
Medicine, Bernard & Shirlee Brown Glaucoma
Laboratory, the Joan and Michael Schneeweiss Stem Cell Fund and Research to Prevent Blindness.
New research
from George Vasmatzis, Ph.D., of the Department of
Laboratory Medicine and Pathology at Mayo Clinic, finds liquid biopsies
from blood tests and DNA sequencing can detect a return of ovarian cancer long before a tumor reappears.
This new line of study opened up
from the
laboratories of the Faculty of
Medicine «leads us to ask ourselves many things, among them, whether LPA is physiologically altering neuroplasticity processes as either an anterograde or a retrograde messenger.
The results of the study were published this week in the journal Nature
Medicine from researchers at Penn's Abramson Cancer Center, including senior author Carl H. June, MD, the Richard W. Vague Professor in Immunotherapy in the department of Pathology and
Laboratory Medicine and director of Translational Research in the ACC, the University of Maryland School of
Medicine, and Adaptimmune Therapeutics plc (Adaptimmune).
These findings are supported by similar research
from the
laboratory of Paul S. Frenette, Ph.D., at the Albert Einstein College of
Medicine, also reported in the Oct. 19 issue of Nature
Medicine.
In addition to McAlpine, Qiu and Sweet, the 17 - person research team included Ghazaleh Haghiashtiani, Shuang - Zhuang Guo, Ruitao Su, Zhijie Zhu, Fanben Meng, Sung Hyun Park
from the University of Minnesota Department of Mechanical Engineering; Zichen Zhao
from the University of Washington WWAMI Institute for Simulation in Healthcare; Badrinath R. Konety
from the University of Minnesota Department of Urology; Mingyu He and Chih - Chang Chu
from Cornell University Fiber Science and Biomedical Engineering Programs; Didarul B. Bhuiyan and Brenda M. Ogle
from the University of Minnesota Department of Biomedical Engineering; Daniel A. Saltzman
from the University of Minnesota Department of Surgery; and Paari Murugan
from the University of Minnesota Department of
Laboratory Medicine and Pathology.
Because the liver receives 70 % of its blood supply
from the intestine, it is important to understand how the gut contributes to liver disease development,» explained lead investigator Yu - Jui Yvonne Wan, PhD, Professor and Vice Chair of the Department of Pathology and
Laboratory Medicine at UC Davis Health.
Three select agents were found at the NIH Clinical Center Department of
Laboratory Medicine, which as you are probably aware, has thousands of microbial isolates
from a historical collection.
Payne and her co-senior author Michael C. Milone, MD, PhD, an assistant professor of Pathology and
Laboratory Medicine, adapted the technique
from the promising anti-cancer strategy by which T cells are engineered to destroy malignant cells in certain leukemias and lymphomas.
Several
laboratories, including one led by Stewart Anderson of the University of Pennsylvania Perelman School of
Medicine, have demonstrated that transplanting inhibitory neurons
from healthy mice has improved symptoms in mice with models of those diseases.
But
from 1997 - 1998, I was a visiting student in the
laboratory of Joseph (Yossi) Schlessinger at the New York University School of
Medicine in the U.S..
A team of researchers
from the Messerli Research Institute at the University of Veterinary
Medicine Vienna, and the Medical University of Vienna showed in
laboratory tests that virus - like particles of harmless adeno - associated viruses (AAV) are particularly suitable as carriers.
For the study, conducted as part of the doctoral thesis of Mahesh Raundhal, a graduate student in the
laboratory of Prabir Ray, Ph.D., Pitt professor of
medicine and co-senior author, the research team examined lung cell samples obtained
from patients also participating in the Severe Asthma Research Program (SARP), a National Heart, Lung, and Blood Institute of the National Institutes of Health - sponsored program to improve the understanding of severe asthma.
Expert panelists
from government, private industry, science and
medicine provided invaluable information on the legal and regulatory challenges faced by professionals practicing in areas affected by personalized
medicine, including labeling issues,
laboratory developed tests, IVD approval and reimbursement and PGx - tailored drugs and companion diagnostics.
«Our research shows that cells derived
from corneal stem cells are attractive candidates for generating corneal cells in the
laboratory,» said Alexander Ljubimov, PhD, director of the Eye Program at the Board of Governors Regenerative
Medicine Institute and principal investigator on this research study.
Using computer - automated, time ‐ lapse photography of embryos in the
laboratory during in - vitro fertilization may improve embryo selection, potentially increasing the chances of pregnancy among women undergoing the procedure, according to new research
from the Perelman School of
Medicine at the University of Pennsylvania and five other fertility centers.
Additional funding
from the Alvin J. Siteman Cancer Center / Barnes Jewish Hospital Foundation Cancer Frontier Fund, the Barnard Trust, the Philip and Sima Needleman Student Fellowship in Regenerative
Medicine, the DeNardo Education and Research Foundation, Alafi Neuroimaging
Laboratory, and the Hope Center for Neurological Disorders.
The University of California, San Diego (UCSD) Human Stem Cell Core Facility, which supports multiple research projects using stem cells to advance the understanding and ultimately the treatment of disease and injury, will receive a $ 2.8 million Shared Research
Laboratory Grant
from the California Institute for Regenerative
Medicine (CIRM).
From June 1977 to July 1979, I was a Jane Coffin Childs postdoctoral fellow in the
laboratory of professor William J. Lennarz in the physiological chemistry department (now biological chemistry) at Johns Hopkins University School of
Medicine.
Julio Martinez - Trujillo, an associate professor in the Department of Physiology and Pharmacology at Western's Schulich School of
Medicine & Dentistry and a Robarts Research Institute scientist, and his collaborators Roberto A. Gulli and Guillaume Doucet
from the Cognitive Neurophysiology
Laboratory, recently published an account of the new toolbox in Journal of Neuroscience Methods.
iBET's infrastructure comprises 16
laboratories fully equipped with state - of - the - art technology (70 m2 each), including a BSL2
laboratory for working with viruses; a GMP Analytical Services Unit certified by the INFARMED (the Portuguese
medicines authority, EMA Portuguese branch) and by DGAV (the Portuguese veterinary authority) for quality control and batch release of human and veterinary pharmaceuticals, biopharmaceuticals as well as experimental new drugs; a GMP Mass - Spectroscopy Unit that provides state - of - the - art MS services to the scientific community and Industry; a 2600 m2 bio-pilot plant supporting production and purification of proteins ATMPs and vaccines
from bench top to 300 L scale and privileged access to GeniBET Biopharmaceuticals, an iBET spin - off producing ATMPs under cGMP certification for phase I / II / III clinical trials.
Dr. Jonathan Kurtis, professor of pathology and
laboratory medicine at Brown, made global headlines last year when he and colleagues revealed a promising protein that combats malaria by preventing the parasite
from exiting red blood cells to spread.
Research Fellow at the
Laboratory of Immunogenetics, Istituto Nazionale per la Ricerca sul Cancro (IST), Genova, Italy in 1988; Research Fellow at the Department of Immunological
Medicine, Clinical Research Centre, London
from 1989 to 1992; Swedish Institute Research Fellow, Department of Immunology, Stockholm University, Stockholm in 1999.
This article by MDI Biological
Laboratory research scientist James Godwin, Ph.D., was originally published in «The Conversation,» an independent source of news and views
from the academic and research community based in Australia, where Godwin was formerly a research fellow at the Australian Regenerative
Medicine Institute (ARMI).
A surgeon, educator and researcher, Kandel comes to UChicago
Medicine from Columbia University College of Physicians and Surgeons in New York where she served as the R. Peter Altman Professor of Surgery and Pediatrics in the Institute for Cancer Genetics and co-director of its Pediatric Tumor Biology
Laboratory.
Watch the video for a research update
from the Dubra
Laboratory at Stanford University School of
Medicine.
On July 26, the California Institute of Regenerative
Medicine announced $ 151 million worth of grants for research that would take stem cell therapies
from the
laboratory to the clinic.
He earned his Ph.D.
from the California Institute of Technology; was a postdoctoral scholar at the Massachusetts Institute of Technology; was Professor of Chemistry at the University of California at Berkeley; was a Principal Investigator at Lawrence Berkeley National
Laboratory and an Investigator of the Howard Hughes Medical Institute; was founder and Institute Director of the Genomics Institute of the Novartis Research Foundation and the California Institute for Biomedical Research (CALIBR); and a founder of Affymax Research Institute, Syrrx, Kalypsys, Phenomix, SymyxTherapeutics, Ilypsa, Ambrx, Ardelyx, and Wildcat Technologies, pioneers in the application of diversity based approaches to problems in chemistry, materials science and
medicine.
This commitment — to bring neuroscience
from the
laboratory to the clinic, the operating room, the pharmacy and the classroom «is something that's really important,» says Jeff Balser, vice chancellor for health affairs and dean of the School of
Medicine.
She received her Ph.D. in Biochemistry
from Wake Forest University School of
Medicine in 1992, where she performed her graduate research on LDL cholesterol metabolism in the
laboratory of Dr Lawrence Rudel.
He arrived at the MDI Biological
Laboratory last year
from the Australian Regenerative
Medicine Institute with the goal of studying the role of the immune system in limb and heart regeneration in the axolotl, or Mexican salamander (see sidebar).
The following is an excerpt
from an interview in Regenerative
Medicine Network, an online publication, with Hermann Haller, M.D., a faculty member at the MDI Biological
Laboratory and director of the Department of Nephrology and Hypertension at Hannover Medical School in Hanover, Germany.
Examples are the inaugural Morton K. Schwartz Award for Cancer Research Diagnostics, Albert Nichols Award for strategic innovation in
laboratory medicine, Norman Kubasik Award for Outstanding contribution to the education of clinical
laboratory scientists, Bernard Gerulat Award for outstanding achievement in clinical chemistry, Carl R. Joliff Award for Outstanding achievement in diagnostic immunology and education, Miriam Reiner Award for outstanding contributions to research in the field of clinical chemistry and Outstanding Contribution to Clinical Chemistry in Research Award (all
from the AACC).
Video research update
from the Huberman
Laboratory at Stanford University School of
Medicine; the purpose of the Huberman Lab is to develop new strategies to monitor, prevent, and treat retinal ganglion cell loss in glaucoma.