Sentences with phrase «laboratory mice also»

Their work with laboratory mice also provides a greater understanding of how this gene impacts Menkes disease as scientists search for a treatment.

Not exact matches

Also, it is reassuring that our results of improved motor unit dysfunction in SMA mice treated with RG3039 mirror the independent findings by the laboratories of Drs. Sumner and Ko.

«We found — counterintuitively — that blocking this immune response against the virus had beneficial effects in lowering the amounts of virus and increasing the ability of the immune response to clear out the virus,» said Kitchen, who is also director of the UCLA Humanized Mouse Core Laboratory.

Co-author and renal physiology expert Jurgen Schnermann, M.D., and members of his laboratory at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), also part of NIH, demonstrated the early and significant decrease in this rate in MMA mice.

He also believes the technique will work reasonably well for studying the structure and function of proteins in most other model organisms, including laboratory mice.

The scientists are able to use tissue not only from laboratory mouse models, but also from human patients.

The study, published Nov. 17 by Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant in humans.

The laboratory's Oncology Preclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under his direction.

They also showed in mice studies and in the laboratory that NCAM2 was broken down by another protein called beta - amyloid, which is the main component of the plaques that build up in the brains of people with the disease.

This could also be the reason why some laboratory strains seem to have lost the ability to produce darcin: Because laboratory mice are usually group - housed, they have been selected to be less aggressive, and not producing darcin could help reduce tensions.

Prusiner, together with Fred Cohen and his colleagues, also at UCSF, and Ruth Gabizon at Hadassah University Hospital in Israel, used human prions to infect a special strain of laboratory mice.

Stem cells obtained in mice also show totipotent characteristics never generated in a laboratory, equivalent to those present in human embryos at the 72 - hour stage of development, when they are composed of just 16 cells.

«Our stem cells also survive outside of mice, in a culture, so we can also manipulate them in a laboratory,» said Abad, adding that: «The next step is studying if these new stem cells are capable of efficiently generating different tissues such as that of the pancreas, liver or kidney.»

«The mutation prevention system maintained antibiotic sensitivity not only in E. coli strains cultured in standard laboratory conditions but also in bacteria that were used to colonize the gastrointestinal tract of gnotobiotic mice.

The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

Finally, Dr. Goldenring's laboratory is also investigating the role of Rab25 as a tumor suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.

Maine is also the home of The Jackson Laboratory, the world's largest non-profit mammalian genetic research facility and the world's largest supplier of genetically purebred mice.

Because he holds a dual appointment with The Jackson Laboratory, which studies mice, he is also seeking insight into how to reverse - engineer the process of regeneration in humans by comparing the genetics of the axolotl, which can regenerate, with those of the mouse, which for the most part can not.

PHENOMIN - ICS is also a key player in the development and the characterisation of new mouse models for many academic laboratories or big pharmaceutical groups, and contributes to European and international leading projects.

«Our findings reveal a critical role for telomere length in a mouse model of age - dependent human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent disease and also a system to test novel therapeutics for aortic valve disease.»

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

Her laboratory also uses mouse models to study other neurogenetic diseases, such as schizophrenia and ALS, with a focus on genes that affect the course of disease and clinical outcomes.

In response to Zasloff's hunch that MSI - 1436 might also stimulate regeneration, MDI Biological Laboratory scientist Voot P. Yin, Ph.D., tested the compound for its ability to regenerate heart muscle tissue in zebrafish, and then in mice.

The HZI will also provide access to laboratory and animal facilities up to BSL3 (including the gnotobiotic unit) and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

In addition to fragile X syndrome, my laboratory also has conducted studies to determine whether the signaling cascades that normally are required for long - lasting synaptic plasticity and memory are altered in mouse models of several developmental disorders, iincluding autism spectrum disorder (ASD), intellectual disability (ID), tuberous sclerosis complex (TSC), and Angelman syndrome.

Not only had Dalldorf and Sickles identified the first members of a very large group of human viruses, but they also introduced and popularized a new and inexpensive animal into the virology laboratory — the suckling mouse.

Dr. Burcham also has experience with laboratory animal pathology, specifically mouse models of neoplasia and autoimmune disease.