Sentences with phrase «laboratory mice by»

Not exact matches

«The 20th century's Thomas Edison has stepped from the stage... the scope of the technologies that sprang from or were transformed by Jobs's Apple laboratories — the Mac, the mouse, the laptop, Pixar, iTunes, iPod, iPhone, iPad — is awesome, as was that from Edison's Menlo Park.»

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

Also, it is reassuring that our results of improved motor unit dysfunction in SMA mice treated with RG3039 mirror the independent findings by the laboratories of Drs. Sumner and Ko.

The result is a repulsive effect, which was used by Yuanming Liu and colleagues at the Jet Propulsion Laboratory in Pasadena, California, to lift a young mouse weighing 10 grams.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.

For the new study, researchers in Diamond's laboratory, led by first author Helen Lazear, PhD, now at the University of North Carolina at Chapel Hill, tested five strains of the Zika virus in the mice: the original strain acquired from Uganda in 1947; three strains that circulated in Senegal in the 1980s; and the French Polynesian strain, which caused infections in 2013 and is nearly identical to the strain causing the current outbreak.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

In a new study published in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampus.

By decreasing the expression of CerS4 in these mice, the Ogretmen laboratory hopes to better define the way in which CerS4 regulates cell migration and metastasis.

The study by neurological scientists at Rush University Medical Center found that feeding cinnamon to laboratory mice determined to have poor learning ability made the mice better learners.

Published in Neuron, scientists at Cold Spring Harbor Laboratory (CSHL) report their discovery of a neural circuit in the mouse olfactory bulb that explains how our mammalian cousins (and by extension, we) are able to adjust the gain on intense odors.

The study, published Nov. 17 by Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant in humans.

They also showed in mice studies and in the laboratory that NCAM2 was broken down by another protein called beta - amyloid, which is the main component of the plaques that build up in the brains of people with the disease.

For example, it could be used to image neurons in living mice by combining the Raman scattering technique with existing methods in which tiny windows are implanted in the brains and spinal cords of laboratory animals.

A July report by the Animal Influenza Laboratory of China's Ministry of Agriculture revealed that the virus quickly replicated in mice and grew increasingly virulent in the process.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

Now scientists have moved a step closer to that possibility by wiping away a month - old memory in genetically engineered laboratory mice, while leaving other memories unchanged.

Further, in laboratory mice, the team found that by deleting this substance, they could produce the type of scarring found in pulmonary fibrosis after lung injury.

«Eliminating endothelial CD146 by conditional knockout in two different mouse models of colitis significantly reduced the severity of inflammation and decreased tumor incidence and tumor progression in a mouse model of CAC,» reports lead investigator Xiyun Yan, PhD, from the Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing.

TOKYO — A Japanese group has generated functional human livers by creating liver precursor cells in the laboratory and then transplanting them into mice to complete the developmental process.

Several laboratories, including one led by Stewart Anderson of the University of Pennsylvania Perelman School of Medicine, have demonstrated that transplanting inhibitory neurons from healthy mice has improved symptoms in mice with models of those diseases.

Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.

A potential new antidepressant developed by University of Bath scientists has shown promise in laboratory trials in mice.

«What we've shown is that we can take these cells out of a mouse and study them and regulate them in the laboratory by providing them with a specific factor,» says Peter C. Gray, a staff scientist in Salk's Clayton Foundation Laboratories for Peptide Biology, who collaborated on the new work with Benjamin T. Spike, a senior research associate in the laboratory of Salk Professor Geoffrey M. Wahl.

By fusing a cat protein and human protein, researchers have successfully blocked cat allergies in laboratory mice.

A team in the laboratory of Atsuo Ogura at the National Institute of Infectious Diseases in Shinjuku, Tokyo, cloned 12 mice by removing nuclei from testis cells and inserting them into enucleated egg cells.

«We think that by restoring the natural «microbial identity» of laboratory mice, we will improve the modeling of complex diseases of free - living mammals, which includes humans and their diseases,» said Barbara Rehermann, M.D., senior author of the paper.

The catalog of mouse and human genes yielded by these genome projects will cut years of time from otherwise painstaking laboratory research.

Additionally, organizations such as Freiburg - based Oncotest, a company founded and directed by Fiebig, and the Jackson Laboratory in Bar Harbor, Maine, provide access to a wide range of PDX mice made from donated tumor tissue.

A team of researchers led by scientists at Cold Spring Harbor Laboratory have for the first time identified stem cells that allow the pituitary glands of mice to grow even after birth.

In: The Laboratory Mouse, 2nd Edition, edited by Hans J. Hedrich.

By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.

Dr. Verdin further found that prolonged intake of a high - fat diet, even in normal mice, can itself reduce the activity of the enzyme produced by SIRT3 — an enzyme his laboratory originally discovered.

We are currently focusing our efforts on an exceptional resource of laboratory mouse strains with proven Mendelian disorders with unknown genetic etiology, strains stewarded by the Mouse Mutant Resource at The Jackson Laboratory for overlaboratory mouse strains with proven Mendelian disorders with unknown genetic etiology, strains stewarded by the Mouse Mutant Resource at The Jackson Laboratory for over 50 ymouse strains with proven Mendelian disorders with unknown genetic etiology, strains stewarded by the Mouse Mutant Resource at The Jackson Laboratory for over 50 yMouse Mutant Resource at The Jackson Laboratory for overLaboratory for over 50 years.

In the April 13, 2007, issue of Science, the research team — led by James C. Lo, an MD, PhD student, in the laboratory of Yang - Xin Fu, MD, PhD, professor of pathology at the University of Chicago — suggest that an engineered protein could keep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for coronary heart disease.

«Our previous studies show the drug we are working on will reduce the symptoms of diabetes in mice by itself,» says Dr. Bruce Hammock, who runs the Hammock Laboratory of Pesticide Biotechnology at UC Davis.

Tie2PEKO were generated by breeding Ng2 - Cre mice (Jackson Laboratory, # 008533) 39 with Tie2fl / fl mice bred in the C57 / Bl6 background37.

A team of Chinese and American researchers led by Dr. Ji - jing Pang of the Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, PR China, and including Jackson Laboratory scientist Bo Chang, M.D., used gene therapy to restore cone function in the retinas of the B6 (A)- Rpe65rd12 / J (005379) mouse, a model of Leber congenital amaurosis — even if the disease has progressed for three months (Li et al. 2011; Pang et al. 2005).

The URMC team, led by Michael Zuscik, Ph.D., associate professor of Orthopaedics in the Center for Musculoskeletal Research (CMSR), Robert Mooney, Ph.D., professor of Pathology and Laboratory Medicine, and Steven Gill, Ph.D., associate professor of Microbiology and Immunology, fed mice a high fat diet akin to a Western «cheeseburger and milkshake» diet.

U.S. Senators Susan Collins and Angus King, Congressman Bruce Poliquin, LePage administration Senior Policy Advisor John Butera and Ellsworth Mayor Robert Crosthwaite were on hand to launch the new facility, which is the first step in the Laboratory's long - range plan to gradually migrate mouse production (except for the research mice used by JAX scientists) from Bar Harbor to Ellsworth, freeing up space in Bar Harbor to expand research and education programs.

Because he holds a dual appointment with The Jackson Laboratory, which studies mice, he is also seeking insight into how to reverse - engineer the process of regeneration in humans by comparing the genetics of the axolotl, which can regenerate, with those of the mouse, which for the most part can not.

The study focused on embryonal rhabdomyosarcoma caused by mutations in the Sonic Hedgehog signaling pathway and used a mouse model developed in Hatley's laboratory.

Bar Harbor, Maine — A research team led by Jackson Laboratory (JAX) Professor David Harrison, Ph.D., reports that acarbose, a drug that is frequently prescribed in Europe for type 2 diabetes, extends the lifespan of mice, with male mice showing a more pronounced effect than the females.

«Our findings reveal a critical role for telomere length in a mouse model of age - dependent human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent disease and also a system to test novel therapeutics for aortic valve disease.»

Molecular signatures of aging in the Diversity Outbred mouse population» by Petr Šimeček, Ph.D from The Jackson Laboratory, Bar Harbor, Maine, USA.

The project was born in 2011, when Golshani read about a miniaturized microscope developed at Stanford University that was light enough to be worn by a laboratory mouse.

Enter the NSG mouse, developed by Jackson Laboratory Professor Leonard Shultz, Ph.D..

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.