Sentences with phrase «laboratory model for a human disease»

Not exact matches

Human tissue grown in the laboratory offers a critical model for understanding the disease process.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

«For example, there is a huge amount of interest and excitement globally in growing cerebral organoids» — miniature brain - like organs that can be studied in laboratory experiments — «from stem cells to model human brain development and disease mechanisms.

«We hypothesized that this might explain why laboratory mice, while paramount for understanding basic biological phenomena, are limited in their predictive utility for modeling complex diseases of humans and other free - living mammals,» said Rosshart.

One potential reason for this discrepancy is that the laboratory tests used in animal models of the disease do not resemble the clinical assessments given to patients, and thus are not predictive of human memory performance.

«Our findings reveal a critical role for telomere length in a mouse model of age - dependent human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent disease and also a system to test novel therapeutics for aortic valve disease.»