Establishing a repository of
laboratory models derived from patient tumor samples that will enable researchers to more thoroughly investigate drug resistance
Not exact matches
Currently, Deng's
laboratory is conducting additional preclinical studies using the human -
derived stem cells from Down syndrome patients and mouse
models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.
In his current position at The Jackson
Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient -
derived xenograft (PDX) mouse
models of human cancers.
NCI's efforts to develop new
laboratory models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient -
derived tumor xenografts.
Methods: As reported in Geophysical Research Letters, the team led by scientists from PNNL and the National Oceanic and Atmospheric Administration's Atlantic Oceanographic and Meteorological
Laboratory used both observations and
models to
derive their new formula.
The mean high temperature projections for 2050 and 2100 were
derived from a suite of 28 climate
models (CMIP5 / Oak Ridge National
Laboratory) under IPCC emissions scenario RCP8.5, averaged over November 22 - 28 for 2030 - 2049 and 2080 - 2099, respectively.»
«Scientific conclusions
derive from an understanding of basic laws supported by
laboratory experiments, observations of nature, and mathematical and computer
modeling.
These simulations can be used as a numerical
laboratory in which we can test the reconstruction methods and assess their potential limitations, by pretending to
derive proxy records of the
model climate, called «pseudo-proxies».