Sentences with phrase «laboratory mouse models»

Laboratory mouse models are commonly used to study A-T; however, mice with A-T do not experience the more debilitating effects that humans do.

In testing on laboratory mouse models and human MDS / AML samples, the researchers identified a novel substrate of TRAF6 called hnRNPA1, an RNA binding protein.

Using laboratory mouse models of inflammatory and neuropathic pain, they showed that the antibody can target the Nav1.7 channel and reduce the pain sensation in these mice.

The scientists are able to use tissue not only from laboratory mouse models, but also from human patients.

This study identifies myomerger as a fundmentally required protein for muscle development using cell culture and laboratory mouse models.

To gain new insights, Luther Bartelt of the University of North Carolina at Chapel Hill and colleagues developed a new laboratory mouse model of co-infection during malnutrition.

Not exact matches

The study involved laboratory cell lines of human leukemia and mouse models of the disease.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

However, in IBD patients and in mouse models of colitis, Enterobacteriaceae species grow uncontrollably, said Dr. Wenhan Zhu, co-lead author and a postdoctoral researcher in the Winter laboratory.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

Apart from a few studies in mouse models and in cell lines, there is no laboratory evidence that synthetic phosphoethanolamine works as a cancer drug.

He also believes the technique will work reasonably well for studying the structure and function of proteins in most other model organisms, including laboratory mice.

Recently, Dr. Cohen's laboratory obtained an ethical approval to test the therapeutic efficiency of NT219 as a treatment in Alzheimer's - model mice, hoping to develop a future treatment for hitherto incurable neurodegenerative disorders.

In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse models of human cancers.

The laboratory's Oncology Preclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under his direction.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

«Mouse models don't represent the full diversity of the human response,» said Joel W. Blanchard, a PhD candidate in the Baldwin laboratory who was co-lead author of the study with Research Associate Kevin T. Eade.

«Eliminating endothelial CD146 by conditional knockout in two different mouse models of colitis significantly reduced the severity of inflammation and decreased tumor incidence and tumor progression in a mouse model of CAC,» reports lead investigator Xiyun Yan, PhD, from the Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing.

Several laboratories, including one led by Stewart Anderson of the University of Pennsylvania Perelman School of Medicine, have demonstrated that transplanting inhibitory neurons from healthy mice has improved symptoms in mice with models of those diseases.

Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.

He said experiments are under way to test the two - drug combination in laboratory models of metastasis - prone prostate cancer, leading eventually to tests in mouse models.

«The one thing that I think that is useful is maybe when people write knockout papers they might describe the housing conditions in more detail,» says Chris Paszty, scientific director at the biotech company Amgen, Inc., headquartered in Thousand Oaks, Calif., who as a postdoctoral researcher at Lawrence Berkeley National Laboratory developed a mouse model for the study of sickle cell anemia.

«We think that by restoring the natural «microbial identity» of laboratory mice, we will improve the modeling of complex diseases of free - living mammals, which includes humans and their diseases,» said Barbara Rehermann, M.D., senior author of the paper.

«We hypothesized that this might explain why laboratory mice, while paramount for understanding basic biological phenomena, are limited in their predictive utility for modeling complex diseases of humans and other free - living mammals,» said Rosshart.

In the laboratory arm of the Joslin study, researchers studied a mouse model of human type 1 diabetes.

The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

Bar Harbor, Maine — October 21, 2004 — The Jackson Laboratory is pleased to announce that it has received support from the Spinal Muscular Atrophy Foundation to make available the first group of mouse models for spinal muscular atrophy (SMA), a neuromuscular disease and the leading genetic cause of death among infants and toddlers.

But while most PDX mice are used as general models of human cancer in the laboratory, others seek to use them as Fiebig originally hoped — as avatars to guide customized patient care.

Congratulations to Umrao Monani, Assistant Professor at the Motor Neuron Center of Columbia University and Cathleen Lutz, Associate Director of Genetic Research Science at The Jackson Laboratory, and their colleagues for their new publication «Postsymptomatic Restoration of SMN Rescues the Disease Phenotype in a Mouse Model of Severe Spinal Muscular Atrophy» in the Journal of -LSB-...]

March 13, 2007 — Cold Spring Harbor, New York — RNA splicing antisense technology studied at Cold Spring Harbor Laboratory (CSHL) effectively corrected an mRNA splicing defect found in spinal muscular atrophy (SMA) patients, and is now ready to be tested in mouse models.

Finally, Dr. Goldenring's laboratory is also investigating the role of Rab25 as a tumor suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.

Scientists in the laboratory of C. Ronald Kahn, M.D., head of Joslin's Integrative Physiology and Metabolism research section, found that brain cholesterol synthesis, the only source of cholesterol for the brain, drops in several mouse models of diabetes.

The laboratory is now analyzing the newly developed mouse models for targeted loss of MYO5B, Rab11a and Rab11 - FIP2 in the intestines and other organs.

In order to better understand biological functions of ADAR in vivo, the laboratory has analyzed the effects of ADAR1 gene mutations in mouse models.

The Jackson Laboratory celebrated the groundbreaking for its new, state - of - the - art vivarium, a 134,900 - square - foot facility to maintain research mouse models, at the institution's Ellsworth, Maine, location on August 2.

The second laboratory continues to focus attention on transplantation immunobiology in mouse models and translational studies of human immunology in transplant recipients.

Researchers have established a strong genetic component for addictive behaviors through studying animal models, including laboratory mice.

Her laboratory has successfully combined electrophysiological expertise with molecular and cell biology approaches to better understand complex mechanisms underlying the memory process in mouse models of AD.

Dr. Coyle's Laboratory for Psychiatric and Molecular Neuroscience takes advantage of insights into recently identified genes that confer risk for schizophrenia and related disorders and translates them into genetic mouse models to determine how these mutations affect brain changes as well as function, neurochemistry, and behavior.

Reagents: antibodies, plasmids, cell lines, RNA libraries, and more Organisms and viruses: model organisms of disease, mouse models, and more Biological specimens Software Protocols Core laboratories eagle - i is different from traditional web publications that list resources (websites, journals, etc.) because the tool allows researchers to: Share resources

Dosing Animals Via Diet Measuring Food and Water Intake in Rats and Mice Laboratory Animals - A Critical Part of In Vivo Research Diet - Induced Metabolic Syndrome in Rodent Models

A team of Chinese and American researchers led by Dr. Ji - jing Pang of the Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, PR China, and including Jackson Laboratory scientist Bo Chang, M.D., used gene therapy to restore cone function in the retinas of the B6 (A)- Rpe65rd12 / J (005379) mouse, a model of Leber congenital amaurosis — even if the disease has progressed for three months (Li et al. 2011; Pang et al. 2005).

Researchers at the MDI Biological Laboratory have been using animal models beyond the well - known laboratory mouse foLaboratory have been using animal models beyond the well - known laboratory mouse folaboratory mouse for decades.

The laboratory mouse, small and easy to breed, has long been biologists» favorite model organism for studying mammalian development.

His laboratory studies early mouse development as a model system to understand molecular mechanisms leading to establishment of pluripotency in vivo.

Implementation of experimental procedures in cancerology and availability of 7 specialized laboratories of biosafety level BSL2 and BSL3, equipped with imaging (bioluminescence / fluorescence), surgery rooms with volatile anaesthesia, means of phenotypic characterization of immunodeficient mouse models, sensitization of murine tumours to radiotherapy and vectorized internal radiotherapy

In 2012 she joined the laboratory of Dr. D.L. Konotyiannis at BSRC AL.Fleming, Greece as postdoctoral scientist, where she worked on the study of the RNA Binding Protein HuR during intestinal and lung inflammation and cancer, using inducible, KO and Tg mouse models and xenografts.

The SMA Foundation has partnered with the The Jackson Laboratory (JAX) to support the importation of key mouse models of SMA into the JAX mouse repository.