Not exact matches
This
study identifies myomerger as a fundmentally required protein for
muscle development using cell culture and
laboratory mouse models.
Since older people have greater potential for improving their fitness than younger people, a follow - up
study conducted by a research group headed by doctor and molecular biologist Helmuth Haslacher from MedUni Vienna, in collaboration with Robert Winker's team from the Health and Prevention Center of the Healthcare Institution for City of Vienna employees, took blood samples from 47 marathon runners before an ergometer test, in order to carry out
laboratory tests to determine levels of analytes, including inflammatory markers,
muscle and liver parameters.
«It's taken years of trial and error, making educated guesses and taking baby steps to finally produce functioning human
muscle from pluripotent stem cells,» said Lingjun Rao, a postdoctoral researcher in Bursac's
laboratory and first author of the
study.
The lead author of the
study is Brian Glancy, Ph.D., an investigator with the
Muscle Energetics
Laboratory of the National Heart, Lung, and Blood Institute (NHLBI), which is part of NIH.
«Calcium signaling regulates many important cellular functions, like
muscle contraction, neural communication, gene transcription and tissue growth,» said Fenfang Li, a postdoctoral research fellow in Zhong's
laboratory and lead author of the
study.
They have generated excitement over the past few decades because scientists can
study them in the
laboratory to discover the genetic switches that control the development of specialized tissues in the embryo and fetus, and also because of their potential to replace body tissues that have broken down, such as pancreatic cells in those with diabetes or heart
muscle cells in those with congestive heart failure.
«This is the first
study to demonstrate that functional
muscle cells can be created in a
laboratory and restore dystrophin in animal models of Duchenne using the human development process as a guide.»
The
study reinforces growing evidence that collagen, which forms fibrous networks in skin, tendons and
muscles, is intimately involved in several cancers, says the paper's corresponding author, Kevin Eliceiri, director of the
Laboratory for Optical and Computational Instrumentation (LOCI) at the University of Wisconsin - Madison.
Professor Buckingham's
laboratory studies the formation of skeletal
muscle.
Today, Yin is a regeneration biologist and assistant professor at MDI Biological
Laboratory in Bar Harbor, leading a team
studying a drug that could nudge the human body into regenerating heart
muscle.
In a
study using human
muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the
laboratory into
muscle, bone and cartilage cells.
This research includes
studies in the
laboratory to discover the mechanisms of nerve degeneration and
muscle atrophy, and clinical
studies to find therapies to slow down or even reverse nerve degeneration and
muscle atrophy.