Sentences with phrase «laboratory studying mouse»

Not exact matches

In 2016 an independent Italian laboratory published a large study on mice.

A study published in the October, 1999 issue of the Archives of Environmental Health found that laboratory mice exposed to various brands of disposable diapers suffered increased eye, nose, and throat irritation, including bronchoconstriction similar to that of an asthma attack.

In a breakthrough study that could improve how people learn and retain information, the researchers significantly boosted the memory and mental performance of laboratory mice through electrical stimulation.

This study identifies myomerger as a fundmentally required protein for muscle development using cell culture and laboratory mouse models.

However, in some studies with laboratory mice, Feinberg had observed that these epigenetic tags varied considerably among the mice even when comparing the same type of tissue in animals that have been living in the exact same conditions.

The study involved laboratory cell lines of human leukemia and mouse models of the disease.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.

In this study, published in the October 31 issue of the Proceedings of the National Academy of Sciences, Sudhir Yadav PhD, a neuroimmunology post-doctoral fellow in the laboratories of Drs. Kouichi Ito, associate professor of neurology, and Suhayl Dhib - Jalbut, professor and chair of neurology, tested mice that were engineered to have a pre-disposition for MS. Because mice would not normally develop MS, researchers used MS - associated risk genes from real patients to genetically engineer mice for this study.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

For the new study, researchers in Diamond's laboratory, led by first author Helen Lazear, PhD, now at the University of North Carolina at Chapel Hill, tested five strains of the Zika virus in the mice: the original strain acquired from Uganda in 1947; three strains that circulated in Senegal in the 1980s; and the French Polynesian strain, which caused infections in 2013 and is nearly identical to the strain causing the current outbreak.

The study, which Shay conducted with colleagues at the University of Florida and University of Nebraska, complements work with mice he leads at his OSU laboratory.

In a new study published in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampus.

«This is the first study to offer an unbiased profile of novel imprinted genes in a mammal other than mice,» said lead author Xu Wang, a postdoctoral associate in the laboratory of Andrew Clark, professor of molecular biology and genetics and the study's senior author.

The study by neurological scientists at Rush University Medical Center found that feeding cinnamon to laboratory mice determined to have poor learning ability made the mice better learners.

Apart from a few studies in mouse models and in cell lines, there is no laboratory evidence that synthetic phosphoethanolamine works as a cancer drug.

He also believes the technique will work reasonably well for studying the structure and function of proteins in most other model organisms, including laboratory mice.

«We now have a really good picture of this abnormality in mice, and we suspect it is very similar in humans,» said Fuming Zhang, a research professor in the laboratory of Robert J. Linhardt, the Ann and John H. Broadbent Jr»59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering, and a member of the Center for Biotechnology and Interdisciplinary Studies at Rensselaer.

Because the mouse is so well studied, its sequence will speed the understanding of how our own genes work, says mouse geneticist Barbara Knowles, director of research at the Jackson Laboratory in Bar Harbor, Maine.

In the new study, published today in Science Advances, Charles Limoli, a molecular biologist at the University of California, Irvine, and colleagues took male mice to a particle accelerator at the NASA Space Radiation Laboratory in Upton, New York.

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing cells.

The study, published Nov. 17 by Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant in humans.

The laboratory's Oncology Preclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under his direction.

In the Rutgers study, Zong and lead author Ji - An Pan, a scientist in his laboratory, looked at liver and heart damage in laboratory mice and found that the mice in which the TRIM21 gene was inactivated suffered little heart or liver damage when put through the same laboratory procedures used to produce tissue damage in mice with the gene.

They also showed in mice studies and in the laboratory that NCAM2 was broken down by another protein called beta - amyloid, which is the main component of the plaques that build up in the brains of people with the disease.

The laboratory where this discovery was made is now planning to study mice presenting with defective MOCOS expression in order to analyze how the enzyme and its regulators influence the development of the nervous system.

Rolls studied laboratory mice that had been gently handled for four hours to prevent them from sleeping while their comrades dozed.

«Mouse models don't represent the full diversity of the human response,» said Joel W. Blanchard, a PhD candidate in the Baldwin laboratory who was co-lead author of the study with Research Associate Kevin T. Eade.

The findings have implications for all aspects of medical and scientific research because laboratory mice underpin studies whose results have a transformative effect on human and animal lives through vaccination and other immune - based therapies.

After introducing stem cells in brain tissue in the laboratory and seeing promising results, Prof. Offen leveraged the study to mice with Alzheimer's disease - like symptoms.

In a seminal series of experiments beginning in the 1960s, Walford studied the effect of depriving laboratory mice of calories and discovered that the less they ate — within reason — the longer they lived.

«Our stem cells also survive outside of mice, in a culture, so we can also manipulate them in a laboratory,» said Abad, adding that: «The next step is studying if these new stem cells are capable of efficiently generating different tissues such as that of the pancreas, liver or kidney.»

Laboratory mouse models are commonly used to study A-T; however, mice with A-T do not experience the more debilitating effects that humans do.

The animals involved in the study were so - called «surplus mice,» raised in laboratories outside Germany.

«What we've shown is that we can take these cells out of a mouse and study them and regulate them in the laboratory by providing them with a specific factor,» says Peter C. Gray, a staff scientist in Salk's Clayton Foundation Laboratories for Peptide Biology, who collaborated on the new work with Benjamin T. Spike, a senior research associate in the laboratory of Salk Professor Geoffrey M. Wahl.

The study, conducted in mice and in laboratory samples, is published February 10 in Cell Host & Microbe.

The researchers had originally obtained this genetically diverse group of inbred laboratory mice to study locations on mouse genomes associated with influenza severity.

«The one thing that I think that is useful is maybe when people write knockout papers they might describe the housing conditions in more detail,» says Chris Paszty, scientific director at the biotech company Amgen, Inc., headquartered in Thousand Oaks, Calif., who as a postdoctoral researcher at Lawrence Berkeley National Laboratory developed a mouse model for the study of sickle cell anemia.

In addition, the mutant mice responded better to treatment with chemotherapy», says Lena Claesson - Welsh, professor at the Department of Immunology, Genetics and Pathology, at Uppsala University and Science for Life Laboratory, who led the study.

The genetic code of the mouse, published on a public Web site (www.ensembl.org), is expected to speed the work of laboratory scientists studying human diseases around the globe.

That's because most studies on single human brain cells use dead rather than living tissue, and many others rely on cells from common laboratory animals, especially mice.

The mouse has been the mainstay of laboratory research on human illness and will most likely become a more essential player in future studies.

In the laboratory arm of the Joslin study, researchers studied a mouse model of human type 1 diabetes.

March 13, 2007 — Cold Spring Harbor, New York — RNA splicing antisense technology studied at Cold Spring Harbor Laboratory (CSHL) effectively corrected an mRNA splicing defect found in spinal muscular atrophy (SMA) patients, and is now ready to be tested in mouse models.

The fundamental genetic similarity between mice and humans allows researchers to infer a human gene's function based on studies with laboratory mice.

Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.

The second laboratory continues to focus attention on transplantation immunobiology in mouse models and translational studies of human immunology in transplant recipients.

Researchers have established a strong genetic component for addictive behaviors through studying animal models, including laboratory mice.